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医療フロンティア展開学

 
大学院科目名 医療フロンティア展開学
医学部教室名  
スタッフ
准教授 髙木 智久
 (京都府立医科大学附属病院臨床研究推進センター・消化器内科併任) 
講師  今井 浩二郎
 (京都府立医科大学附属病院臨床研究推進センター)
助教  村島 京子
 (京都府立医科大学附属病院遺伝子診療部遺伝相談室・がんゲノム医療センター)
研究内容

 臨床研究の歴史を参照しつつ、正しい臨床研究のありかたを科学的、倫理的そして社会的側面から検討する。また医療行政を注視し、再生医療分野など、基礎・臨床研究が遅滞なく進むよう体制整備を行い、本学における研究開発を先導する。また、ゲノム医療の臨床実装が急速に進展する医療環境に遅れることなく、本学附属病院における遺伝医療およびがんゲノム医療関連業務を支援し、遺伝カウンセリングを担っていく。  

研究業績
〇再生医療の推進に向けて. 医療経済研究機構レター . No.223 Page29-36. (2013)
 
〇Kinoshita S, Koizumi N, Ueno M, Okumura N, Imai K, et al. Tanaka H, Yamamoto Y, Nakamura T, Inatomi T, Bush J, Toda M, Hagiya M, Yokota I, Teramukai S, Sotozono C, Hamuro J. Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy. N Engl J Med. 2018 Mar 15;378(11):995-1003. (2018)
 
〇Sakaguchi K, Ono H, Nakatsukasa K, Ishikawa T, Hasegawa Y, Takahashi M, Niikura N, Koizumi K, Sakurai T, Shigematsu H, Takahashi S, Taira S, Suzuki M, Narui K, Miura D, Yamada K, Yoshimura M, Shioya H, Konishi E, Isao Y, Imai K, Fujikawa K, Taguchi T; Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society. Efficacy of denosumab for restoring normal bone mineral density in women receiving adjuvant aromatase inhibitors for early breast cancer. Medicine (Baltimore). 2019 Aug;98(32):e16770. (2019)
 
〇Fujioka A, Yanishi K, Yukawa A, Imai K, Yokota I, Fujikawa K, Yamada A, Naito A, Shoji K, Kawamata H, Higashi Y, Ishigami T, Sasaki KI, Tara S, Kuwahara K, Teramukai S, Matoba S. A Multicenter Prospective Interventional Trial of Therapeutic Angiogenesis Using Bone Marrow-Derived Mononuclear Cell Implantation for Patients With Critical Limb-Threatening Ischemia Caused by Thromboangiitis Obliterans. Circ J. 2023 Mar 10. Online ahead of print.
 
〇Tomida A, Chiyonobu T, Tokuda S, Miyachi M, Murashima K, Hirata M, Nakagawa M, Iehara T, Kuroda J, Takayama K. Pleomorphic rhabdomyosarcoma in a young adult harboring a novel germline MSH2 variant. Hum Genome Var. 2022 Mar 8;9(1):8.(2022)
 
〇 Aoi W, Inoue R, Mizushima K, Honda A, Björnholm M, Takagi T, Naito Y. Exercise-acclimated microbiota improves skeletal muscle metabolism via circulating bile acid deconjugation. iScience. 2023 Feb 21;26(3):106251.
 
〇Uchiyama K, Takagi T, Mizushima K, Hirai Y, Asaeda K, Sugaya T, Kajiwara-Kubota M, Kashiwagi S, Minagawa Y, Hotta Y, Tanaka M, Inoue K, Katada K, Kamada K, Ishikawa T, Yasuda H, Konishi H, Kishimoto M, Naito Y, Itoh Y. Mucosal Addressin Cell Adhesion Molecule 1 Expression Reflects Mucosal Inflammation and Subsequent Relapse in Patients with Ulcerative Colitis. J Crohns Colitis. 2023 May 3;17(5):786-794.
 
〇Kitae H, Takagi T, Naito Y, Inoue R, Azuma Y, Torii T, Mizushima K, Doi T, Inoue K, Dohi O, Yoshida N, Kamada K, Uchiyama K, Ishikawa T, Konishi H, Itoh Y. Gut Microbiota Associated with Clinical Relapse in Patients with Quiescent Ulcerative Colitis. Microorganisms. 2022 May 18;10(5):1044.
 
Takagi T, Inoue R, Oshima A, Sakazume H, Ogawa K, Tominaga T, Mihara Y, Sugaya T, Mizushima K, Uchiyama K, Itoh Y, Naito Y. Typing of the Gut Microbiota Community in Japanese Subjects. Microorganisms. 2022 Mar 20;10(3):664.
 
Takagi T, Okayama T, Asai J, Mizushima K, Hirai Y, Uchiyama K, Ishikawa T, Naito Y, Itoh Y. Topical application of sustained released-carbon monoxide promotes cutaneous wound healing in diabetic mice. Biochem Pharmacol. 2022 May;199:115016.
 
〇Ushiroda C, Takagi T, Fuke N, Mizushima K, Hirai Y, Higashimura Y, Harusato A, Kamada K, Uchiyama K, Ishikawa T, Aizawa K, Suganuma H, Itoh Y, Naito Y. Lycopene intake induces colonic regulatory T cells in mice and suppresses food allergy symptoms. Pediatr Allergy Immunol. 2022 Jan;33(1):e13691.
 
Takagi T, Uchiyama K, Kajiwara-Kubota M, Kashiwagi S, Toyokawa Y, Hotta Y, Tanaka M, Inoue K, Dohi O, Yoshida N, Kamada K, Ishikawa T, Konishi H, Kishimoto M, Yagi N, Naito Y, Itoh Y. The efficacy of linked color imaging for the endoscopic diagnosis of mucosal healing in quiescent ulcerative colitis. J Gastroenterol Hepatol. 2021 Sep;36(9):2448-2454.
 
Takagi T, Naito Y, Higashimura Y, Uchiyama K, Okayama T, Mizushima K, Katada K, Kamada K, Ishikawa T, Itoh Y. Rectal administration of carbon monoxide inhibits the development of intestinal inflammation and promotes intestinal wound healing via the activation of the Rho-kinase pathway in rats. Nitric Oxide. 2021 Feb 1;107:19-30.
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