当科では基礎研究、臨床研究を通じて免疫疾患の病態を解明し、より良い診断・治療に結びつけられるよう下記のプロジェクトを進めています。

 

炎症病態における生理活性脂質の役割の解析

線維化における炎症凝固連関についての解析

シングルセルRNAシーケンスを用いた免疫疾患の病態解明

iPS細胞技術を用いた免疫疾患の病態解明と新規細胞治療開発

関節リウマチ患者における新規バイオマーカーの探索

全身性エリテマトーデスにおける末梢血免疫細胞フェノタイプの解析

全身性エリテマトーデスの全国多施設共同レジストリ（LUNA）

ANCA関連血管炎の全国多施設共同レジストリ（J-CANVAS）

Omura S, et al. Effectiveness of intravenous methylprednisolone pulse in patients with severe microscopic polyangiitis and granulomatosis with polyangiitis. Rheumatology (Oxford). 2024 Apr 12:keae219.

 

Sofue H, et al. Optimal Dose of Intravenous Cyclophosphamide during remission induction therapy in ANCA-associated vasculitis: a retrospective cohort study of J-CANVAS. Mod Rheumatol. 2023 Oct 6:road099.

 

Omura S, et al. Association between hypogammaglobulinaemia and severe infections during induction therapy in ANCA-associated vasculitis: from J-CANVAS study. Rheumatology (Oxford). 2023;kead138.

 

Hirano A et al. Association between early immunophenotypic changes and therapeutic response of belimumab in patients with systemic lupus erythematosus. Lupus. 2023;32:63-73.

 

Kawahito Y, et al. Drug treatment algorithm and recommendations from the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis-secondary publication. Mod Rheumatol. 2023;33:21-35.

 

Kida T, et al. Latent trajectory modelling of pulmonary artery pressure in systemic sclerosis: a retrospective cohort study. RMD Open. 2022;8:e002673.

 

Fujioka K, et al. Effectiveness and safety of allergen immunotherapy in patients with allergic rhinitis complicated by rheumatic autoimmune diseases: a case series study. Allergy Asthma Clin Immunol. 2022;18:63.

 

Kasahara A, et al. Risk of adrenal insufficiency in patients with polymyalgia rheumatica versus patients with rheumatoid arthritis: A cross-sectional study. Mod Rheumatol. 2022 20;32:891-898.

 

Sagawa T, et al. Role of necroptosis of alveolar macrophages in acute lung inflammation of mice exposed to titanium dioxide nanoparticles. Nanotoxicology. 2021;15:1312-1330.

 

Kaneshita S, et al. CG223, a novel BET inhibitor, exerts TGF-β1-mediated antifibrotic effects in a murine model of bleomycin-induced pulmonary fibrosis. Pulm Pharmacol Ther. 2021;70:102057.

 

Sagawa T, et al. Exposure to particulate matter upregulates ACE2 and TMPRSS2 expression in the murine lung. Environ Res. 2021;195:110722.

 

Kida T, et al. Effectiveness and safety of chronic hepatitis C treatment with direct-acting antivirals in patients with rheumatic diseases: A case-series. Mod Rheumatol. 2020 ;30:1009-1015.

 

Kaneshita S, et al. Risk Factors for Cytomegalovirus Disease with Cytomegalovirus Re-activation in Patients with Rheumatic Disease. Modern Rheumatology. 2020;30:109-115.

 

Kida T, et al. Association between preexisting lung involvements and the risk of diffuse alveolar hemorrhage in patients with microscopic polyangiitis: A multi-center retrospective cohort study. Modern Rheumatology. 2020;30:338-344.

 

Sagawa T, et al. Utility of Coagulation Markers for the Prediction of Rapidly Progressive Interstitial Lung Disease in Patients with Dermatomyositis. Lung. 2019;197:437-442.

 

Inoue T, et al. Upregulation of sphingosine-1-phosphate receptor 3 on fibroblast-like synoviocytes is associated with the development of collagen-induced arthritis via increased interleukin-6 production. Plos one.2019; 14(6):e0218090.

 

Sofue H, et al. Thrombopoietin receptor agonist, splenectomy and intravenous immunoglobulin for immune thrombocytopaenia with systemic lupus erythematosus. Rheumatology (Oxford). 57(8): 1495-1497, 2018.

 

Kida T, et al. Roles of high-mobility group box 1 and thrombin in murine pulmonary fibrosis and the therapeutic potential of thrombomodulin. Am J Physiol Lung Cell Mol Physiol. 314(3): L473-L483, 2018.

 

Nagahara H, et al. Role of allograft inflammatory factor-1 in bleomycin-induced lung fibrosis. Biochem Biophys Res Commun. 495(2): 1901-1907, 2018.

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