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免疫内科学/内科学教室(内分泌・免疫内科学部門)

免疫内科学HP http://www.f.kpu-m.ac.jp/k/itinai/index.html

大学院科目名 免疫内科学
医学部教室名 内科学教室(内分泌・免疫内科学部門)
スタッフ
病院教授  川人 豊
 
講師    河野 正孝
助教    和田 誠
 
研究内容
当科では基礎研究、臨床研究を通じて免疫疾患の病態を解明し、より良い診断・治療に結びつけられるよう下記のプロジェクトを進めています。
 
炎症病態における生理活性脂質の役割の解析
線維化における炎症凝固連関についての解析
シングルセルRNAシーケンスを用いた免疫疾患の病態解明
iPS細胞技術を用いた免疫疾患の病態解明と新規細胞治療開発
関節リウマチ患者における新規バイオマーカーの探索
全身性エリテマトーデスにおける末梢血免疫細胞フェノタイプの解析
全身性エリテマトーデスの全国多施設共同レジストリ(LUNA)
ANCA関連血管炎の全国多施設共同レジストリ(J-CANVAS)
研究業績
Kaneshita S, et al. CG223, a novel BET inhibitor, exerts TGF-β1-mediated antifibrotic effects in a murine model of bleomycin-induced pulmonary fibrosis. Pulm Pharmacol Ther. 2021;70:102057.
 
Sagawa T, et al. Exposure to particulate matter upregulates ACE2 and TMPRSS2 expression in the murine lung. Environ Res. 2021;195:110722.
 
Kida T, et al. Effectiveness and safety of chronic hepatitis C treatment with direct-acting antivirals in patients with rheumatic diseases: A case-series. Mod Rheumatol. 2020 ;30:1009-1015.
 
Kaneshita S, et al. Risk Factors for Cytomegalovirus Disease with Cytomegalovirus Re-activation in Patients with Rheumatic Disease. Modern Rheumatology. 2020;30:109-115.
 
Kida T, et al. Association between preexisting lung involvements and the risk of diffuse alveolar hemorrhage in patients with microscopic polyangiitis: A multi-center retrospective cohort study. Modern Rheumatology. 2020;30:338-344.
 
Sagawa T, et al. Utility of Coagulation Markers for the Prediction of Rapidly Progressive Interstitial Lung Disease in Patients with Dermatomyositis. Lung. 2019;197:437-442.
 
Inoue T, et al. Upregulation of sphingosine-1-phosphate receptor 3 on fibroblast-like synoviocytes is associated with the development of collagen-induced arthritis via increased interleukin-6 production. Plos one.2019; 14(6):e0218090.
 
Sofue H, et al. Thrombopoietin receptor agonist, splenectomy and intravenous immunoglobulin for immune thrombocytopaenia with systemic lupus erythematosus. Rheumatology (Oxford). 57(8): 1495-1497, 2018.
 
Kida T, et al. Roles of high-mobility group box 1 and thrombin in murine pulmonary fibrosis and the therapeutic potential of thrombomodulin. Am J Physiol Lung Cell Mol Physiol. 314(3): L473-L483, 2018.
 
Nagahara H, et al. Role of allograft inflammatory factor-1 in bleomycin-induced lung fibrosis. Biochem Biophys Res Commun. 495(2): 1901-1907, 2018.
 
Kukida Y, et al. Efficacy of abatacept in patients with rheumatoid arthritis, as assessed by magnetic resonance imaging of bilateral hands. Int J Rheum Dis. 21(9): 1678-1685, 2017.
 
Kida T, et al. Intravascular lymphoma in a rheumatoid arthritis patient following short-term methotrexate treatment. Rheumatology (Oxford). 56(2): 318-320, 2017.
 
Nagahara H, et al. Allograft inflammatory factor-1 in the pathogenesis of bleomycin-induced acute lung injury. Biosci Trends. 10(1): 47-53, 2016.
 
Seno T, et al. Once-weekly teriparatide improves glucocorticoid-induced osteoporosis in patients with inadequate response to bisphosphonates. SpringerPlus. 5(1): 1-7, 2016.
 
Fujii W, et al. Monocarboxylate transporter 4, associated with the acidification of synovial fluid, is a novel therapeutic target for inflammatory arthritis. Arthritis Rheumatol. 67(11): 2888-96, 2015.
 
Fujioka K, et al. Inhibition of osteoclastogenesis by osteoblast-like cells genetically engineered to produce interleukin-10. Biochem Biophys Res Commun. 456(3): 785-91, 2015.
 
Murakami K, et al. Knock out of S1P3 receptor signaling attenuates inflammation and fibrosis in bleomycin-induced lung injury mice model. Plos one. 9(9): e106792, 2014.
 
Kadoya M, et al. Allograft inflammatory factor-1 stimulates chemokine production and induces chemotaxis in human peripheral blood mononuclear cells. Biochem Biophys Res Commun. 448(3): 287-91, 2014
 
Fujii W, et al. Myeloid-derived suppressor cells play crucial roles in the regulation of mouse collagen- induced arthritis. J Immunol. 191(3): 1073-81, 2013.
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教室独自のHP

http://www.f.kpu-m.ac.jp/k/itinai/index.html

〒602-8566. 京都市上京区河原町通広小路上る梶井町465

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