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小児外科学/外科学教室(小児外科学部門)

 小児外科HP http://pedsurg.kpu-m.ac.jp/index.php

大学院科目名 小児外科学
医学部教室名 外科学教室(小児外科学部門)
スタッフ
教授  田尻 達郎
 
 
准教授     古川 泰三
講師                  青井 重善
助教(学内講師)文野 誠久
助教      東 真弓
助教      坂井 宏平
研究内容
研究内容
主な基礎研究
(1) 間葉系幹細胞を用いた神経芽腫のhoming効果および分化誘導療法
(2) 新規分子標的薬を用いた神経芽腫治療の前臨床試験
(3) 先天性横隔膜ヘルニア重症肺低形成に対する胎児治療の開発
(4) 先天性骨格筋欠損に対する再生医療の開発
 
主な臨床研究
(1) リンパ管腫に対するmTOR阻害剤の臨床効果
(2) 新生児先天性横隔膜ヘルニアの治療標準化に関する研究
(3) 短腸症候群の包括的治療戦略の構築
(4) 新たな低侵襲手術治療の開発
(5) 小児固形腫瘍に対する外科治療
研究業績
1) Tajiri T, Kimura O, Fumino S, Furukawa T, Iehara T, Souzaki R, Kinoshita Y, Koga Y, Suminoe A, Hara T, Kohashi K, Oda Y, Hishiki T, Hosoi H, Hiyama E, Taguchi T: Surgical strategies for unresectable hepatoblastomas. J Pediatr Surg 47: 2194-2198, 2012.
2) Kimura O, Furukawa T, Higuchi K, Takeuchi Y, Fumino S, Aoi S, Tajiri T: Impact of our new protocol on the outcome of the neonates with congenital diaphragmatic hernia. Pediatr Surg Int 29: 335-339, 2013.
3) Fumino S, Higuchi K, Aoi S, Furukawa T, Kimura O, Tajiri T: Clinical analysis of liver fibrosis in choledochal cyst. Pediatr Surg Int 29:1097-1102, 2013.
4) Sakai K, Kimura K, Kimura O, Aoi S, Furukawa T, Masumoto K, Fumino S, Tajiri T. Prenatal administration of neuropeptide bombesin promotes lung development in a rat model of nitrofen-induced congenital diaphragmatic hernia. 49: 1749-1752, 2014.
5) Fumino S, Kimura K, Iehara T, Nishimura M, Nakamura S, Souzaki R, Nishie A, Taguchi T, Hosoi H,Tajiri T: Validity of image-defined risk factors in localized neuroblastoma: A report from two centers in Western Japan. J Pediatr Surg 50: 2102-2106, 2015.
6) Fumino S, Maniwa J, Takeuchi Y, Sakai K, Higashi M, Aoi S, Furukawa T, Kimura O, Tajiri T: Surgical intervention and perioperative risk factors of retroperitoneal teratomas in children: a single institution experience. Pediatr Surg Int 32: 909-914, 2016.
7) Tanaka T, Higashi M, Kimura K, Wakao J, Fumino S, Iehara T, Hosoi H, Sakai T, Tajiri T : MEK inhibitors as a novel therapy for neuroblastoma: Their in vitro effects and predicting their efficacy. J Pediatr Surg, 51: 2074-2079, 2016.
8) Kimura K, Kishida T, Wakao J, Tanaka T, Higashi M, Fumino S, Aoi S, Furukawa T, Mazda O, Tajiri T: Tumor-homing effect of human mesenchymal stem cells in a TH-MYCN mouse model of neuroblastoma. J Pediatr Surg, 51: 2068-2073, 2016.
9) Takeuchi Y, Tanaka T, Higashi M, Fumino S, Iehara T, Hosoi H, Sakai T, Tajiri T: In vivo effects of short- and long-term MAPK pathway inhibition against neuroblastoma. J Pediatr Surg, 53: 2454-2459, 2018.
10) Maniwa J, Fumino S, Kimura K, Tanaka T, Higashi M, Kishida T, Mazda O, Tajiri T: Novel mesenchymal stem cell delivery system as targeted therapy for neuroblastoma using the TH-MYCN mouse model. J Pediatr Surg, 54: 2600-2605, 2019.
11) Inoue M, Tsuchiya Y, Koike N, Umemura Y, Inokawa H, Togashi Y, Maniwa J, Higashi M, Fumino S, Tajiri T, Yagita K: Enhanced metastatic growth after local tumor resection in the presence of synchronous metastasis in a mouse allograft model of neuroblastoma. Pediatr Surg Int, 35: 1403-1411, 2019.
12) Kim K, Higashi M, Fumino S, Tajiri T: Derivation of neural stem cells from human teratomas. Stem Cell Res, 41: 101633, 2019.
13) Takayama S, Sakai K, Fumino S, Furukawa T, Kishida T, Mazda O, Tajiri T: An intra-amniotic injection of mesenchymal stem cells promotes lung maturity in a rat congenital diaphragmatic hernia model. Pediatr Surg Int, 35: 1353-1361, 2019.
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