大学院科目名 | 分子生化学 |
医学部教室名 | 分子医科学教室(分子生化学部門) |
スタッフ |
教授 中田 慎一郎
講師 吉田 達士
講師(学内) 山崎 健太
講師(学内) 忠垣 憲次郎
プロジェクト研究員 富田 亜希子
研究補助員 生木 裕也
特任教授 奥田 司
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研究内容 |
「DNA修復基礎研究から、がんゲノム変異発生機構の探索、そして安全な遺伝子修正法の開発へ」をテーマに研究を展開しています。DNA損傷応答・修復の分子機構の解明を目指して研究をすすめながら、その研究成果を利用して、がん治療標的探索をおこなったり、安全な遺伝子修正法の開発を行うなど、実用に向けた応用研究も行っています。意欲的な若手研究者・大学院学生の参加を歓迎いたします。 |
研究業績 |
(1)Kawakatsu R, Tadagaki K, Yamasaki K, Yoshida T*
Venetoclax efficacy on acute myeloid leukemia is enhanced by the combination with butyrate
Sci Rep 14: 4(1):4975. doi: 10.1038/s41598-024-55286-0. 2024
(2)Tomita A, Sasanuma H, Owa T, Nakazawa Y, Shimada M, Fukuoka T, Ogi T, Nakada S*
Inducing multiple nicks promotes interhomolog homologous recombination to correct heterozygous mutations in somatic cells.
Nat Commun 14, Article number: 5607, 2023
(3)Yoshida T, Yamasaki K, Tadagaki K
Caspase inhibition improves viability and efficiency of liposomal transfection
Sci Rep 13(1):21868. doi: 10.1038/s41598-023-49027-y.
(4)Nakajima K#, Zhou Y#,Tomita A,Hirade Y, Gurumurthy CB, Nakada S*
Precise and Efficient Nucleotide Substitution near Genomic Nick via Non-Canonical Homology-Directed Repair
Genome Res. 2018. 28: 223-230.
(5)Takahashi TS, Hirade Y, Toma A, Sato Y, Yamagata A, Goto-Ito S, Tomita A, Nakada S*. Fukai S*. Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168
Nat Commun. 2018 Jan 12;9(1):170.
Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice
Mol Cell. 2014 Feb 20;53(4):617-30. doi: 10.1016/j.molcel.2014.01.030.
(7)Nakada S*, Yonamine RM, Matsuo K.
RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1
Cancer Res. 2012 Oct 1;72(19):4974-83. doi: 10.1158/0008-5472.CAN-12-1057. 2012
Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13
J Biol Chem. 2012 Jul 27;287(31):25860-8
(9)Nakada S*, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D*
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1
Nature. 2010 Aug 19;466(7309):941-6.
(10)Nakada S, Chen GI, Gingras AC, Durocher D*
PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint
EMBO Rep. 2008
(11)Kolas NK#, Chapman JR#, Nakada S#, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D.
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
Science. 2007 Dec 7;318(5856):1637-40.
(12)Nakada S, Katsuki Y, Imoto I, Yokoyama T, Nagasawa M, Inazawa J, Mizutani S*
Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations
J Clin Invest. 2006 Jan;116(1):80-9.
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問い合わせ先 |
TEL:075-251-5315 |
教室独自のHP | 作成予定 |