京都府立医科大学：医系化学／化学教室

化学教室HP　https://kpu-m.medchem/index.html

大学院科目名

医系化学

医学部教室名

化学教室

スタッフ

教授　　大庭　誠

准教授　　　　　　武元　宏泰

助教(学内講師)　　梅野　智大

研究内容

　有機化学・合成化学基盤にモノをつくり、生命科学・基礎医学を取り入れて細胞や動物を用いた機能評価を行い、病気の予防・治療が可能な医薬品や研究ツールとして使える技術の開発を目指して、以下の研究に取り組んでいます。

研究業績

Yokoo, H.*; Dirisala, A.; Uchida, S.; Oba, M.* Oligosarcosine conjugation of arginine-rich peptide improves the intracellular delivery of peptide/pDNA complexes. ACS Biomater. Sci. Eng. 2024, 10(2), 890-896.
Zhu, C.; Takemoto, H.; Higuchi, Y.*; Yamashita, F. Programmed immobilization of living cells using independent click pairs. Biochem. Biophys. Res. Commun. 2024, 699, 149556.
Oba, M.*; Nakajima, S.; Misao, K.; Yokoo, H.; Tanaka, M. Effect of helicity and hydrophobicity on cell-penetrating ability of arginine-rich peptides. Bioorg. Med. Chem. 2023, 91, 117409.
Oba, M.*; Shibuya, M.; Yamaberi, Y.; Yokoo, H.; Uchida, S.; Ueda, A.; Tanaka, M.* An amphipathic structure of a dipropylglycine-containing helical peptide with sufficient length enables safe and effective intracellular siRNA delivery. Chem. Pharm. Bull. 2023, 71(3), 250-256.
Umeno, T.*; Fujihara, M.; Matsumoto, S.; Iizuka, N.; Usui, K.; Karasawa, S.* Quantitative and nondestructive colorimetric amine detection method for the solid-phase peptide synthesis as an alternative to the Kaiser test. Anal. Chem. 2023, 95, 15803-15809.
Umeno, T.*; Muroi, L.; Kayama, Y.; Usui, K.; Hamada, K.; Mizutani, A.; Karasawa, S.* Naphthyridine-based electron push−pull-type amine-reactive fluorescent probe for sensing amines and proteins in aqueous media. Bioconjugate Chem. 2023, 34, 1439-1446.
Yokoo, H.; Misawa, T.; Kato, T.; Tanaka, M.; Demizu, Y.*; Oba, M.*Development of delivery carriers for plasmid DNA by conjugation of a helical template to oligoarginine. Bioorg. Med. Chem. 2022, 72, 116997.
Takemoto, H.*; Awaad, A.; Iizuka, M; Ogi, K.; Mochida, Y.; Ranneh, A. H.; Toyoda, M.; Matsui, M.; Nomoto, T.; Honda, Y.; Hayashi, K.; Tomoda, K.; Ohtake, T.; Miura, Y.; Nishiyama, N.* Changeable net charge on nanoparticles facilitates intratumor accumulation and penetration. J. Control. Release 2022, 346, 392-404.
Umeno, T.*; Seto, R.; Matsumoto, S.; Fujihara, M.; Karasawa, S.* Basic fluorescent protonation-type pH probe sensitive to small DpKa of methanol and ethanol. Anal. Chem. 2022, 94, 10400-10407.
Uchida, S*; Yamaberi, Y.; Tanaka, M.; Oba, M.* A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of delivered mRNA. Nanoscale, 2021, 13(45), 18941-18946.
Yamaberi, Y.; Eto, R.; Umeno, T.; Kato, T.; Doi, M.; Yokoo, H.; Oba, M.*; Tanaka, M.* Synthesis of (S)-(–)-cucurbitine and conformation of its homopeptides. Org. Lett. 2021, 23, 4358-4362.
Komoto, K.; Nomoto, T.*; Muttaqien, S. E.; Takemoto, H.; Matsui, M.; Miura, Y.; Nishiyama, N.* Iron chelation cancer therapy using hydrophilic block copolymers conjugated with deferoxamine. Cancer Sci. 2021, 112, 410-421.
Furukawa, K.; Tanaka, M.; Oba. M.* siRNA delivery using amphipathic cell-penetrating peptides into human hepatoma cells. Bioorg. Med. Chem. 2020, 28(8), 115402.
Takemoto, H.*; Inaba, T.; Nomoto, T.; Matsui, M.; Liu, X.; Toyoda, M.; Honda, Y.; Taniwaki, K.; Yamada, N.; Kim, J.; Tomoda, K.; Nishiyama, N.* Polymeric modification of gemcitabine via cyclic acetal linkage for enhanced anticancer potency with negligible side effects. Biomaterials 2020, 235, 119804.
Takemoto, H.*; Wang, C. L.; Nomoto, T.; Matsui, M.; Tomoda, K.; Nishiyama, N.* Pyruvate responsiveness based on α-oxohydrazone formation for intracellular siRNA release from polyion complex (PIC)-based carriers. Biomacromolecules 2019, 20, 2305-2314.

問い合わせ先

TEL: 075-703-4937

FAX: 075-703-4937

e-mail: moba@koto.kpu-m.ac.jp

教室独自のHP

https://kpu-m.medchem.jp/index.html

医系化学／化学教室

化学教室HP https://kpu-m.medchem/index.html

化学教室HP　https://kpu-m.medchem/index.html