京都府立医科大学：医系化学／化学教室

化学教室HP　https://kpu-m.medchem/index.html

大学院科目名

医系化学

医学部教室名

化学教室

スタッフ

教授　　大庭　誠

教授大庭　誠

准教授武元　宏泰

助教（学内講師）　梅野　智大

研究内容

　有機化学・合成化学基盤にモノをつくり、生命科学・基礎医学を取り入れて細胞や動物を用いた機能評価を行い、病気の予防・治療が可能な医薬品や研究ツールとして使える技術の開発を目指して、以下の研究に取り組んでいます。

研究業績

Ibuki, S., Umeno, T., Oba, M.*, Takemoto, H.* Rearrangement in diamine-based polyzwitterion side chains for the modulated pH responsiveness regardless of their comparable pKa values. Macromol. Rapid Commun. in press.
Oba, M.*, Nonaka, H., Umeno, T., Kato, T., Doi, M., Ueda, A., Tanaka, M.* Redox-responsive side chain structural changes in a seven-membered cyclic a,a-disubstituted a-amino acid with a disulfide bond enable reversible conformational changes in peptides. ChemPlusChem 2025, 90(4), e202400772.
Umeno, T.*, Tanaka, M., Fujihara, M., Iizuka, N., Matsumoto, S., Usui, K., Karasawa, S.* Advanced pH indicators consisting of BODIPY and coumarin fluorophores with a guanidinyl structure capable of methanol recognition. Asian J. Org. Chem. 2025, 14, e202400605.
Imayoshi, A.*, Yokoo, H., Kawaguchi, M., Tsubaki, K., Oba, M.* Visualization of plasmid DNA deliver system by complementary fluorescence labeling of arginine-rich peptides. Chem. Pharm. Bull. 2024, 72(10), 856-861.
Naka, M., Umeno, T., Shibuya, M., Yamaberi, Y., Ueda, A., Tanaka, M., Takemoto, H., Oba, M.* Intracellular delivery of plasmid DNA using amphipathic helical cell-penetrating peptides containing dipropylglycine.Chem. Pharm. Bull. 2024, 72(5), 512-517.
Yokoo, H.*; Dirisala, A.; Uchida, S.; Oba, M.* Oligosarcosine conjugation of arginine-rich peptide improves the intracellular delivery of peptide/pDNA complexes. ACS Biomater. Sci. Eng. 2024, 10(2), 890-896.
Zhu, C.; Takemoto, H.; Higuchi, Y.*; Yamashita, F. Programmed immobilization of living cells using independent click pairs. Biochem. Biophys. Res. Commun. 2024, 699, 149556.
Oba, M.*; Nakajima, S.; Misao, K.; Yokoo, H.; Tanaka, M. Effect of helicity and hydrophobicity on cell-penetrating ability of arginine-rich peptides. Bioorg. Med. Chem. 2023, 91, 117409.
Oba, M.*; Shibuya, M.; Yamaberi, Y.; Yokoo, H.; Uchida, S.; Ueda, A.; Tanaka, M.* An amphipathic structure of a dipropylglycine-containing helical peptide with sufficient length enables safe and effective intracellular siRNA delivery. Chem. Pharm. Bull. 2023, 71(3), 250-256.
Umeno, T.*; Fujihara, M.; Matsumoto, S.; Iizuka, N.; Usui, K.; Karasawa, S.* Quantitative and nondestructive colorimetric amine detection method for the solid-phase peptide synthesis as an alternative to the Kaiser test. Anal. Chem. 2023, 95, 15803-15809.
Umeno, T.*; Muroi, L.; Kayama, Y.; Usui, K.; Hamada, K.; Mizutani, A.; Karasawa, S.* Naphthyridine-based electron push−pull-type amine-reactive fluorescent probe for sensing amines and proteins in aqueous media. Bioconjugate Chem. 2023, 34, 1439-1446.
Yokoo, H.; Misawa, T.; Kato, T.; Tanaka, M.; Demizu, Y.*; Oba, M.*Development of delivery carriers for plasmid DNA by conjugation of a helical template to oligoarginine. Bioorg. Med. Chem. 2022, 72, 116997.
Takemoto, H.*; Awaad, A.; Iizuka, M; Ogi, K.; Mochida, Y.; Ranneh, A. H.; Toyoda, M.; Matsui, M.; Nomoto, T.; Honda, Y.; Hayashi, K.; Tomoda, K.; Ohtake, T.; Miura, Y.; Nishiyama, N.* Changeable net charge on nanoparticles facilitates intratumor accumulation and penetration. J. Control. Release 2022, 346, 392-404.
Umeno, T.*; Seto, R.; Matsumoto, S.; Fujihara, M.; Karasawa, S.* Basic fluorescent protonation-type pH probe sensitive to small DpKa of methanol and ethanol. Anal. Chem. 2022, 94, 10400-10407.
Uchida, S*; Yamaberi, Y.; Tanaka, M.; Oba, M.* A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of delivered mRNA. Nanoscale, 2021, 13(45), 18941-18946.

問い合わせ先

TEL: 075-703-4937

FAX: 075-703-4937

e-mail: moba@koto.kpu-m.ac.jp

教室独自のHP

https://kpu-m.medchem.jp/index.html

医系化学／化学教室

化学教室HP https://kpu-m.medchem/index.html

化学教室HP　https://kpu-m.medchem/index.html