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医系化学/化学教室

化学教室HP http://www.f.kpu-m.ac.jp/y/medchem/index.html

大学院科目名 医系化学
医学部教室名 化学教室
スタッフ
  教授  大庭 誠
              准教授 内田 智士
 
研究内容
 有機化学・合成化学基盤にモノをつくり、生命科学・基礎医学を取り入れて細胞や動物を用いた機能評価を行い、病気の予防・治療が可能な医薬品や研究ツールとして使える技術の開発を目指して、以下の研究に取り組んでいます。
研究業績

1. Furukawa, K.; Tanaka, M.; Oba. M.* siRNA delivery using amphipathic cell-penetrating peptides into human hepatoma cells. Bioorg. Med. Chem. 2020, 28(8), 115402.
2. Koji, K.; Yoshinaga, N.; Mochida, Y.; Hong, T.; Miyazaki, T.; Kataoka, K.; Osada, K.; Cabral, H.*; Uchida, S.*, Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo. Biomaterials 2020, 261, 120332
3. Dirisala, A.; Uchida, S.*; Toh, K.; Li, J.; Osawa, S.; Tockary, T. A.; Liu, X.; Abbasi, S.; Hayashi, K.; Mochida, Y.; Fukushima, S.; Kinoh, H.; Osada, K.; Kataoka, K.*, Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines. Science Advances 2020, 6 (26), eabb8133.
4. Oba, M.*; Ito, Y.; Umeno, T.; Kato, T.; Tanaka, M. Plasmid DNA delivery using cell-penetrating peptide foldamers composed of Arg-Arg-Aib repeating sequences. ACS Biomater. Sci. Eng. 2019, 5, 5660-5668.
5. Oba, M.*; Nagano, Y.; Kato, T.; Tanaka, M. Secondary structures and cell-penetrating abilities of arginine-rich peptide foldamers. Sci. Rep. 2019, 9, 1349.
6. Yoshinaga, N.; Cho, E.; Koji, K.; Mochida, Y.; Naito, M.; Osada, K.; Kataoka, K.; Cabral, H.*; Uchida, S.*, Bundling mRNA Strands to Prepare Nano-Assemblies with Enhanced Stability Towards RNase for In Vivo Delivery. Angew. Chem. Int. Ed. 2019, 58 (33), 11360-11363.
7. Yoshinaga, N.; Uchida, S.*; Naito, M.; Osada, K.; Cabral, H.; Kataoka, K.*, Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection. Biomaterials 2019, 197, 255-267
8. Uchida, S.*; Yoshinaga, N.; Yanagihara, K.; Yuba, E.; Kataoka, K.; Itaka, K.*, Designing immunostimulatory double stranded messenger RNA with maintained translational activity through hybridization with poly A sequences for effective vaccination. Biomaterials 2018, 150, 162-170.
9. Furukawa, K; Oba, M.*; Toyama, K.; Opiyo, G. O.; Demizu, Y.; Kurihara, M.; Doi, M; Tanaka, M.* Low pH-triggering changes in peptide secondary structures. Org. Biomol. Chem. 2017, 15(30), 6302-6305.
10. Oba, M.*; Kunitake, M.; Kato, T.; Ueda, A.; Tanaka, M.* Enhanced and prolonged cell-penetrating abilities of arginine-rich peptides by introducing cyclic a,a-disubstituted a-amino acids with stapling. Bioconjugate Chem. 2017, 28(7), 1801-1806.

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FAX: 075-703-4937
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