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細胞分子機能病理学／病理学教室（細胞分子機能病理学部門）

細胞分子機能病理学HP　https://www.kpum-pcr.jp

大学院科目名 細胞分子機能病理学
医学部教室名 病理学教室（細胞分子機能病理学部門）
スタッフ
教授　原田　義規
 
准教授　　　　　小形　岳寛
助教（学内講師）中尾　龍太
助教　　　　　　望月　健太郎
 
特任教授　　　　田中　秀央
特任教授　　　　髙松　哲郎
研究内容
バイオフォトニクス（最先端の光技術とバイオテクノロジーの融合）を活用し、機能分子のイメージングおよび機能制御技術を駆使して、疾患の発生メカニズムの解明に取り組んでいる。独自に開発した各種の先端光学顕微鏡を用い、病態に伴う機能的・形態的変化を分子・細胞・組織・臓器レベルで同時に視覚化することで、病態の発症機序の解明と革新的な組織診断技術の創出を目指している。
 
研究内容
1. 光学的手法を用いた腫瘍微小環境の解析
2. ラマン散乱分光法による心筋バイアビリティの評価
3. 心筋機能分子の可視化による心疾患の病態解明
4. 微小癌やリンパ節転移の検出を目的とした分子イメージング
5. プロトポルフィリンを用いたがんの蛍光検出とヘム生合成制御機構の研究
研究業績
  1. Tamura S., Mochizuki K., Kumamoto Y., Morishita Y., Yamanaka M., Ho WJ., Harada Y., Fujita K., Tanaka H. Phase-targeting rapid cryofixation of the beating heart and histological analysis unveil contractile state-dependent sarcomere dynamics Sci. Rep., 16, 11484 (2026)
  2. Nakao R., Honda M., Mitsugi N., Nagata H., Harada Y. Fulminant Food Aspiration-Induced Pneumonia Leading to Tension Pyopneumothorax after Proctectomy: An Autopsy Case Surg. Case Rep., 12, 25-0529 (2026)
  3. Kurahashi T., Harada Y., Dai P. In Vitro Generation of Brown and Beige Adipocytes via Cellular Reprogramming Cell Reprogram., 27, 216-227 (2025)
  4. Tsuji K., Yamanaka M., Kumamoto Y., Tamura S., Miyamura W., Kubo T., Mizushima K., Kono K., Hirano H., Shiozaki M., Zhao X., Xi H., Sugiura K., Fukushima S., Kunimoto T., Tanabe Y., Nishida K., Mochizuki K., Harada Y., Smith NI., Heintzmann R., Yu Z., Wang MC., Nagai T., Tanaka H., Fujita K. Time-deterministic cryo-optical microscopy Light Sci. Appl., 14, 275 (2025)
  5. Pelissier A., Hashimoto K., Mochizuki K., Taylor JN., Clement JE., Kumamoto Y., Fujita K., Harada Y., Komatsuzaki T. Beyond the Nucleus: Cytoplasmic Dominance in Follicular Thyroid Carcinoma Detection Using Single-Cell Raman Imaging across Multiple Devices Anal. Chem., 97, 12998-13009 (2025)
  6. Sawai Y., Hayakawa M., Yasuda H., Nakao R., Ogata T., Nakamura A., Mochizuki K., Takata T., Miyake H., Sogame Y., Morimura R., Kurahashi T., Dai P., Konishi E., Itoh Y., Tanaka H., Harada Y. Oleic acid enhances the proliferation of gallbladder cancer cells via the GPR120/ERK pathway Biochem. Biophys. Res. Commun., 754, 151530 (2025)
  7. Koyama Y., Nakao R., Sato J., Honda M., Inamori O., Tanaka N., Morinaga Y., Konishi E., Harada Y., Tanaka H., Yasuda H., Itoh Y., Nagahara H., Niioka H., Takamatsu T. H&E Style Translation Using CycleGAN for Deep Ultraviolet-Excitation Fluorescence Images of Pancreatic Endoscopic Ultrasound-Fine Needle Aspiration/Biopsy Toward Slide-Free Rapid Patology Acta Histochem. Cytochem., 58, 59-67 (2025)
  8. Mizushima K., Kumamoto Y., Tamura S., Yamanaka Y., Mochizuki K., Li M., Egochi S., Dodo K., Harada Y., Smith N.I., Sodeoka M., Tanaka H., Fujita K. Raman microscopy of cryofixed biological specimens for high-resolution and high-sensitivity chemical imaging Sci.Adv., 10, eadn0110 (2024)
  9. Minamikawa T., Sakaguchi R., Harada Y., Tanioka H., Inoue S., Hase H., Mori Y., Takamatsu T., Yamasaki Y., Morimoto Y., Kawasaki M., Kawasaki M. Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected withy column-structured silica overlayer Light: Science & Applications, 13, 299 (2024)
  10. Takata T., Nakamura A., Yasuda H., Miyake H., Sogame Y., Sawai Y., Hayakawa M., Mochizuki K., Nakao R., Ogata T., Ikoma H., Konishi E., Harada Y., Otsuji E., Itoh Y., Tanaka H. Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors Acta Histochem. Cytochem., 57, 57-66 (2024)
  11. Tabata K., Kawagoe H., Taylor J.N., Mochizuki K., Kubo T., Clement J.E., Kumamoto Y., Harada Y., Nakamura A., Fujita K., Komatsuzaki T. On-the-fly Raman microscopy guaranteeing the accuracy of discrimination Proc. Natl. Acad. Sci. U.S.A., 121, e2304866121 (2024)
  12. Tsuji Y., Ogata T., Mochizuiki K., Tamura S., Morishita Y., Takamatsu T., Matoba S., Tanaka H. Myofibroblasts impair myocardial impulse propagation by heterocellular connexin43 gap-junctional coupling through micropores Front. Physiol., 15, 1352911 (2024)
  13. Mochizuki K., Kumamoto Y., Maeda S., Tanuma M., Kasai A., Takemura M., Harada Y., Hashimoto H., Tanaka H., Smith N.I., Fujita K. High-throughput line-illumination Raman microscopy with multislit detection Biomed. Opt. Express, 14, 1015-1026 (2023)
  14. Helal K.M, Cahyadi H, Taylor J.N, Okajima A, Tabata K, Kumamoto Y, Mochizuki K, Itoh Y, Takamatsu T, Tanaka H, Fujita K, Komatsuzaki T, Harada Y. Raman imaging of rat non-alcoholic fatty liver tissues reveals distinct biomolecular states FEBS Lett. doi:10.1002/1873-3468.14600 (2023)
  15. Morishita Y, Tamura S, Mochizuki K, Harada Y, Takamatsu T, Hosoi H, Tanaka H. Generation of myocyte agonal Ca2+ waves and contraction bands in perfused rat hearts following irreversible membrane permeabilisation Sci. Rep. 13, 803 (2023)
  16. Hayakawa M, Taylor J.N, Nakao R, Mochizuki K, Sawai Y, Hashimoto K, Tabata K, Kumamoto Y, Fujita K, Konishi E, Hirano S, Tanaka H, Komatsuzaki T, Harada Y. Lipid droplet accumulation and adipophilin expression in follicular thyroid carcinoma Biochem. Biophys. Res. Commun. 640, 192-201 (2023)
  17. Harada Y, Sogame Y, Nakao R, Ogata T, Yasuda H, Sakagami J, Itoh Y, Tanaka H. Autopsy of a Patient with Primary Pancreatic Lymphoma with Findings Resembling Severe Acute Pancreatitis Int. Med. 0757-22 (2022)
  18. Harada Y, Murayama Y, Takamatsu T, Otsuji E, Tanaka H Fluorescence Imaging for Tumor Detection: Recent Advances and Challenges Int. J. Mol. Sci. 23, 6478 (2022)
  19. Takemura M, Mochizuki K, Harada Y, Okajima A, Hayakawa M, Dai P, Itoh Y, Tanaka H. Label-free Assessment of the Nascent State of Rat Non-alcoholic Fatty Liver Disease Using Spontaneous Raman Microscopy Acta Histochem. Cytochem. 55, 57-66 (2022)
  20. Beika M, Harada Y, Minamikawa T, Yamaoka Y, Koizumi N, Murayama Y, Konishi H, Shiozaki A, Fujiwara H, Otsuji E, Takamatsu T, Tanaka H. Accumulation of Uroporphyrin I in Necrotic Tissues of Squamous Cell Carcinoma after Administration of 5-Aminolevulinic Acid Int. J. Mol. Sci. 22, 10121 (2021)
  21. Ikemoto K, Hashimoto K, Harada Y, Kumamoto Y, Hayakawa M, Mochizuki K, Matsuo K, Yashiro K, Yaku H, Takamatsu T, Tanaka H. Raman Spectroscopic Assessment of Myocardial Viability in Langendorff-Perfused Ischemic Rat Hearts Acta Histochem. Cytochem. 54, 65-72 (2021)
  22. Morita M, Hideo T, Kumamoto Y, Nakamura A, Harada Y, Ogata T, Sakaguchi K, Taguchi T, Takamatsu T. Fluorescence-based discrimination of breast cancer cells by direct exposure to 5-aminolevulinic acid Cancer Med. 8, 5524-5533 (2019)
  23. Helal KM, Taylor JN, Cahyadi H, Okajima A, Tabata K, Itoh Y, Tanaka H, Fujita K, Harada Y, Komatsuzaki T. Raman spectroscopic histology using machine learning for nonalcoholic fatty liver disease FEBS Lett. 593, 2535-2544 (2019)
  24. Taylor JN, Mochizuki K, Hashimoto K, Kumamoto Y, Harada Y, Fujita K, Komatsuzaki T. High-resolution Raman microscopic detection of follicular thyroid cancer cells with unsupervised machine learning J. Phys. Chem. B 123, 4358-4372 (2019)
  25. Yamamoto T, Minamikawa T, Harada Y, Yamaoka Y, Tanaka H, Yaku H, Takamatsu T. Label-free evaluation of myocardial infarct in surgically excised ventricular myocardium by Raman spectroscopy Sci. Rep. 8, 14671 (2018)
  26. Matsuyama T, Tanaka H, Ishibashi-Ueda H, Takamatsu T. Spatiotemporally non-uniform Ca2+ dynamics of cardiac Purkinje fibers in mouse myocardial infarct J. Histochem. Cytochem. 65, 655-667 (2017)
  27. Tanaka H, Matsuyama T, Takamatsu T. Towards an integrated understanding of cardiac arrhythmogenesis - Growing roles of experimental pathology Pathol. Int. 67, 8-16 (2017)
  28. Ohira S, Tanaka H, Harada Y, Minamikawa T, Kumamoto Y, Matoba S, Yaku H, Takamatsu T. Label-free detection of myocardial ischaemia in the perfused rat heart by spontaneous Raman spectroscopy Sci. Rep. 7, 42401 (2017)
  29. Koizumi N, Harada Y, Beika M, Minamikawa T, Yamaoka Y, Dai P, Murayama Y, Yanagisawa A, Otsuji E, Tanaka H, Takamatsu T. Highly sensitive fluorescence detection of metastatic lymph　nodes of gastric cancer with photo-oxidation of protoporphyrin IX Eur. J. Surg. Oncol. 42, 1236-1246 (2016)
  30. Nishiki-Muranishi N, Harada Y, Minamikawa T, Yamaoka Y, Dai P, Yaku H, Takamatsu T. Label-free evaluation of myocardinal infarction and its repair by spontaneous Raman spectroscopy Anal. Chem. 86, 6903-10 (2014)
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