京都府立医科大学：分子標的予防医学／保健・予防医学教室（予防医学部門）

大学院科目名

分子標的予防医学

医学部教室名

保健・予防医学教室（予防医学部門）

スタッフ

教授　武藤　倫弘

准教授　　宮本　真吾

講師　　　　　　　渡邉　元樹

助教（学内講師）　飯泉　陽介
助教　　　　　　　増田　光治

研究内容

がん予防剤の実用化に向けたがんハイリスクグループに対する臨床介入試験

遺伝子の発現制御機構に基づいた新しいがんの予防法あるいは前がん病変検査・治療法の開発

リスク因子や分子機構に基づき、副作用軽減・併用による相互作用・感受性亢進・耐性克服を意図したがん分子標的併用予防法の開発

産学連携によるドラッグリポジショニング、機能性食品による予防法の探索と開発

ケモプロテオミクス・ケモインフォマティクスによる天然物のがん予防効果の機序解明および新規がん予防成分のin silicoスクリーニングへの展開

がん特異的代謝異常に着目した新規がん予防法の開発

変異遺伝子による代謝調節に着目した発がん予防物質検索、in vivo有効性評価

ケミカルバイオロジーの手法を用いた、がん予防剤や機能性食品成分の標的タンパク質の同定と精密な作用機構解析

がん予防教育・啓発に係るD&I（普及と実装）研究

研究業績　　

論文業績

2021年

Yokoyama　R, Kojima H, Takai R, OhtaT, Maeda H, Miyashita K, Mutoh M, Terasaki M. Effects of CLIC4 on fucoxanthinol-induced apoptosis in human colorectal cancer cells. Nutr Cancer. 73(5):889-898, 2021.doi: 10.1080/01635581.2020.1779760. (IF= 2.805)
Hamoya T, Fujii G, Iizumi Y, Narita T, Komiya M, Matsuzawa Y, Miki K, Kondo T, Kishimoto S, Watanabe K, Wakabayashi K, Sakai T, Toshima J, Mutoh M. Artesunate Inhibits Intestinal Tumorigenesis through Inhibiting Wnt Signaling. Carcinogenesis. 2021 Feb 11;42(1):148-158. doi: 10.1093/carcin/bgaa084. (IF= 4.944)
Terasaki M. Uehara O, Ogasa S, Sano T, Kubota A, Kojima H, Tanaka T, Maeda H, Miyashita K, Mutoh M. Alteration of fecal microbiota by fucoxanthin results in prevention of colorectal cancer in AOM/DSS mice.Carcinogenesis.2021 Feb25;42(2):210-219. doi:10.1093/carcin/bgaa100. (IF= 4.944)
Terasaki M,　Takahashi S, Nishimura R, Kubota A, Kojima H, Ohta T, Hamada J, Kuramitsu Y, Maeda H, Miyashita K, Takahashi M, Mutoh M. A marine carotenoid of fucoxanthinol accelerates the growth of human pancreatic cancer PANC-1 cells. Nutr Cancer. 2021 Feb 16;1-16. doi: 10.1080/01635581.2020.1863994. (IF= 2.805)
Ishikawa H, Mutoh M, Sato Y, Doyama H, Tajika M, Tanaka S, Horimatsu T, Takeuchi Y, Kashida H, Tashiro J, Ezoe Y, Nakajima T, Ikematsu, H Hori S, Suzuki S, Otani T, Takayama T, Ohda Y, Mure K, Wakabayashi K, Sakai T. Chemoprevention with low-dose aspirin, mesalazine, or both in patients with familial adenomatous polyposis without previous colectomy (J-FAPP Study IV): a multicentre, double-blind, randomised, two-by-two factorial design trial. Lancet Gastroenterol Hepatol. 2021 Jun;6(6):474-481. doi: 10.1016/S2468-1253(21)00018-2. (IF= 45.042)
Watanabe M, Yamada Y, Kurumida Y, Kameda T, Sukeno M, Iizuka-OhashiM, Sowa Y, Iizumi Y, Takakura H, Miyamoto S, Sakai T, Mutoh M. Rabdosianone I, a bitter diterpene from an oriental herb, suppresses thymidylate synthase expression by directly binding to ANT2 andPHB2.Cancers(Basel).2021Feb26;13(5):982. doi:10.3390/cancers13050982. (IF= 6.575)
Terasaki M, Inoue T, Murase W, Kubota A, Kojima H, Kojoma M, Ohta T, Maeda H, Miyashita K, Mutoh M, Takahashi M. A fucoxanthinol induces apoptosis in a pancreatic intraepithelial neoplasia cell.　Cancer Genomics Proteomics.
2021 Mar-Apr;18(2):133-146. doi: 10.21873/cgp.20248. (IF= 4.069)
Terasaki M, Hamoya T, Kubota A, Kojima H, Tanaka T, Maeda H, Miyashita K, Mutoh M. Fucoxanthin prevents colorectal canecr development in dextran sodium sulfate-treated Apc Min/+ mice. AnticancerRes.
　 2021Mar;41(3):1299-1305. doi: 10.21873/anticanres.14887.(IF= 2.48)
Yoshida N, Mano Y, Matsuda T, Sano Y, Inoue K, Hirose R, Dohi O, Itoh Y, Sobue T, Takeuchi Y, Nakayama T, Mutoh M, Ishikawa H. Complications of colonoscopy in Japan: An analysis using large-scale health insurance claims data. J Gastroenterol Hepatol. 2021 Oct;36(10):2745-2753. doi: 10.1111/jgh.15531. (IF= 4.369)
Takahashi M, Hamoya T, Narita T, Fujii G, Totsuka Y, Hagio M, Tashiro K, Komiya M, Mutoh M. Complex modulating effects of dietary calcium intake on obese mice. In Vivo. 2021 Jul-Aug;35(4):2107-2114. doi: 10.21873/invivo.12480. (IF= 2.155)
Terasaki M, Kubota A, Kojima H, Maeda H, Miyashita K, Kawagoe C, Mutoh M, Tanaka T. Fucoxanthin and colorectal cancer prevention. Cancers (Basel). 2021 May 14;13(10):2379.doi: 10.3390/cancers13102379. (IF= 6.575)
YWatanabe M, Ishikawa H, Ishiguro S, Mutoh M. Importance of sessile serrated lesions in a patient with familial adenomatous polyposis. Clin J Gastroenterol.
　 2021 Dec;14(6):1667-1670. doi: 10.1007/s12328-021-01498-0.
(IF= 3.062)
Tsunematsu Y, Hosomi K, Kunisawa J, Sato M, Shibuya N, Saito E, Murakami H, Yoshikawa Y, Iwashita Y, Miyoshi N, Mutoh M, Ishikawa H, Sugimura H, Miyachi M, Wakabayashi K, Watanabe K. Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria. BMC Microbiol.
2021 Aug 24;21(1):235. doi: 10.1186/s12866-021-02292-1. (IF= 4.465)
Yokoyama R, Kubota A, Kojima H, Tanaka T, Mutoh M, Terasaki M. Detection of cells displaying high expression of CLIC4 in tumor tissue of patients with colorectal cancer. In Vivo. Nov-Dec 2021;35(6):3165-3173. doi: 10.21873/invivo.12611. (IF= 2.155)
Mure K, Tomono S, Mure M, Horinaka M, Mutoh M, Sakai T, Ishikawa H, Wakabayashi K. The combination of cigarette smoking and alcohol drinking synergistically increases reactive carbonyl species in human plasma. Int J Mol Sci.
2021 Aug 22;22(16):9043. doi: 10.3390/ijms22169043. (IF= 6.009)
Murase W, Kamakura Y, Kawakami S, Yasuda A, Wagatsuma M, Kubota A, Kojima H, Ohta T, Takahashi M, Mutoh M, Tanaka T, Maeda H, Miyashita K, Terasaki M. Fucoxanthin prevents pancreatic tumorigenesis in C57BL/6J　mice that received allogenic and orthotopic transplantations of the cancer cells. Int J Mol Sci.
2021 Dec 19;22(24):13620. doi: 10.3390/ijms222413620. (IF= 6.009)
Zhou T, Hirayama Y, Tsunematsu Y, Suzuki N, Tanaka S, Uchiyama N, Goda Y, Yoshikawa Y, Iwashita Y, Sato M, Miyoshi N, Mutoh M, Ishikawa H, Sugimura H, Wakabayashi K, Watanabe K. Isolation of new colibactin Metabolites from wild-type Escherichia coli and In Situ trapping of a mature colibactin derivative. J Am Chem Soc. 2021 Apr 14;143(14):5526-5533. doi: 10.1021/jacs.1c01495. (IF= 16.383)
Yamazaki H, Shimizu M, Otani T, Mizugaki A, Mure K, Suzuki S,
Ishikawa H. Effects of polymorphic cytochrome P450 2A6 genotypes on chemoprevention using daily low-dose aspirin against colorectal tumors in a Japanese cohort: Insights into future personalized treatments. Journal of Pharmaceutical Health Care and Sciences. 2021, 7, 1, 26, doi: 10.1186/s40780-021-00209-8. (IF= 0.8)
Tomita N, Ishida H, Tanakaya K, Yamaguchi T, Kumamoto K, Tanaka T,Hinoi T, Miyakura Y, Hasegawa H, Takayama T, Ishikawa H, Nakajima T, Chino A, Shimodaira H, Hirasawa A, Nakayama Y, Sekine S, Tamura K, Akagi K, Kawasaki Y, Kobayashi H, Arai M, Itabashi M, Hashiguchi Y, Sugihara K, Japanese Society for Cancer of the Colon, Rectum. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2020 for the Clinical Practice of Hereditary Colorectal Cancer. Int J Clin Oncol. 2021, 26, 8, 1353-419, doi: 10.1007/s10147-021-01881-4.（遺伝性大腸癌診療ガイドライン２０２０年版英語論文）(IF= 3.850)
Morita S, Goda K, Yano T, Kaise M, Kato M, Inoue H, Niwa Y, Kodashima　S, Miyahara R, Ochiai A, Ikegami M, Ha00209-8matani S, Shimoda T, Ohkura Y, Aida J, Nakanishi Y, Takubo K, Yoshimura K, Ishikawa H, Muto M. Multicenter prospective in vivo study of Endocytoscope System (ECS) for superficial esophageal cancer. J Gastroenterol. 2021, 56, 9, 808-13, doi: 10.1007/s00535-021-01810-2. (IF= 6.772)
Ogawa-Ochiai K, Ishikawa H, Li H, Quang LV, Kimoto I, Takamura M,
Hongawa T, Hane Y, Suzuki S, Okajima M, Mori K, Ito M, Takami A.Immunological and preventive effects of hochuekkito and kakkonto against coronavirus disease in healthcare workers: A retrospective observationalstudy.FrontPharmacol.2021,12,766402.doi:10.3389/fphar.2021.766402. (IF= 5.988)
Nishida K, Morishima Y, Pascual-Marqui RD, Minami S, Yamane T,Michikura M, Ishikawa H, Kinoshita T. Mindfulness augmentation for anxiety through concurrent use of transcranial direct current stimulation: a randomized double-blind study. Sci Rep. 2021, 11, 1,22734, doi: 10.1038/s41598-021-02177-3. (IF= 4.996)
Shimamoto Y, Ishiguro S, Takeuchi Y, Nakatsuka S, Yunokizaki H, Ezoe Y, Nakajima T, Matsuno K, Nakahira H, Tanaka K, Ishihara R, Takayama T, Yoshida T, Ishikawa H. Gastric Neoplasms in Patients with Familial Adenomatous Polyposis, Endoscopic and Clinicopathological Features. Gastrointest endosc. 2021, 94,6,1030-42. e2. doi: 10.1016/j.gie.2021.06.010. (IF= 10.396)
Ogawa-Ochiai, K, Osuga K, Nozaki T, Tazuke Y, Sakai S, Uehara S,Hoshi R, Ishikawa H, Yoshimura K, Okuyama H. Effect of Japanese Kampo medicine, eppikajutsuto, in patients with lymphatic malformation: A retrospective observational study. Medicine (Baltimore). 2021, 100, 51, e28420, doi: 10.1097/MD.0000000000028420. (IF= 1.889)
Hasuo H, Ishikawa H, Matsuoka H. Relationship between the number of breaths that maximizes heart rate variability and height in patients with incurable cancers. Complement Ther Med. 2021, 5, 63, 102780. doi: 10.1016/j.ctim.2021.102780. (IF= 2.446)
Morita M, Iizuka-Ohashi M, Watanabe M, Narita T, Kato C, KakibuchiD, Kitano F, Ouchi Y, Sakaguchi K, Taguchi T. Oxidative stress induces EGFR inhibition-related skin cell death. J Clin Biochem Nutr 68(3):235-242, 2021. (IF= 3.179)
武藤倫弘, 中尾俊雅, 藤井元. 免疫学的アプローチによるがん予防の可能
性. J・JSMUFF 14(4): 1-5, 2021.
石川秀樹. がんの化学予防 2．アスピリンによる大腸腺腫、大腸癌の化予防. 癌と化学療法. 1425-8, 2021.
石川秀樹. 家族性大腸腺腫症. 週刊日本医事新報. 34-5, 2021.
秋山泰樹, 荒瀬光一, 永田淳, 井上譲, 鳥越貴行, 遠山篤史, 富崎一向,石井雅宏, 島尻正平, 田中久美子, 吉野潔, 藤本直浩, 高山哲治, 石川秀樹, 石田秀行, 平田敬治.デスモイド腫瘍による尿性腹水をきたした家族性大腸腺腫症の1 例. 遺伝性腫瘍. 36-40, 2021.

2020年

Terasaki M, Kuramitsu Y, Kojoma M, Kim S-Y, Tanaka T, Maeda H, Miyashita K, Kawagoe C, Kohno S, Mutoh M. High fucoxanthin wakame (Undaria pinnatifida) prevents tumor microenvironment formation in an AOM/DSS mouse carcinogenic model. J Functional Foods. 2020 Jan 64, 103709. doi.org/10.1016/j.jff.2019.103709
Terasaki M, Ikuta M, Kojima H, Tanaka T, Maeda H, Miyashita K, Mutoh M. Dietary fucoxanthin induces anoikis in colorectal adenocarcinoma through suppressing integrin signaling in a murine colorectal cancer model. J. Clin. Med. 2020, 9(1), 90; doi.org/10.3390/jcm9010090
Kurokawa Y, Fujii G, Tomono S, Shingo M, Hamoya T, Takahashi M, Narita T, Komiya M, Kobayashi M, Higami Y, Mutoh M. The radical scavenger NZ-419 suppresses intestinal polyp development in Apc-mutant mice. J Clin Med. 2020 Jan 18;9(1). pii: E270. doi: 10.3390/jcm9010270.
Adachi S, Hamoya T, Fujii G, Narita T, Komiya M, Miyamoto S, Kurokawa Y, Takahashi M, Takayama T, Ishikawa H, Tashiro K, Mutoh M. Theracurmin inhibits intestinal polyp development in Apc-mutant mice by inhibiting inflammation-related factors. Cancer Sci. 2020 Apr;111(4):1367-1374. doi: 10.1111/cas.14329.
Kawanishi M, Shimohara C, Oda Y, Hisatomi Y, Tsunematsu Y, Sato M, Hirayama Y, Miyoshi N, Iwashita Y, Yoshikawa Y, Sugimura H, Mutoh M, Ishikawa H, Wakabayashi K, Yagi T, Watanabe K. Genotyping of a gene cluster for production of colibactin and in vitro genotoxicity analysis of Escherichia coli strains obtained from the Japan Collection of Microorganisms. Genes Environ. 2020 Mar 11;42:12. doi: 10.1186/s41021-020-00149-z.
Yin T, Bayanjargal S, Fang B, Inaba C, Mutoh M, Kawahara T, Tanaka S, Watanabe J. Lactobacillus plantarum Shinshu N-07 isolated from fermented Brassica rapa L. attenuates visceral fat accumulation induced by high-fat diet in mice. Beneficial Microbes. 2020 11 (7); 655-667. doi.org/10.3920/BM2020.0009
武藤倫弘, 飯泉陽介, 藤井元. がん予防学の科学的・社会的側面。特集：環境因子と発がん,　実験医学39(11), 1862-1866, 2020.
武藤倫弘, 成田匠, 藤井元. 大腸がん予防剤としてのアスピリンの歴史と現状の課題. 京都府立医科大学雑誌, 129(7), 469-477, 2020.
Ishikawa H, Mutoh M, Yoshimura K, Fujii G, Nakamura T, Takeshita T, Wakabayashi K, Sakai T. Very long-term treatment with a Lactobacillus probiotic preparation, Lactobacillus Casei strain Shirota, suppresses weight loss in the elderly. Nutrients. 2020 May 29;12(6):1599. doi: 10.3390/nu12061599.
武藤倫弘, 曽和義広, 藤井元.日本におけるゲノムリスク告知の現状と課題.日中医学, 35(3), 21-25, 2020.
Terasaki M, Kimura R, Kubota A, Kojima H, Tanaka T, Maeda H, Miyashita K, Mutoh M. Continuity of tumor microenvironmental suppression in AOM/DSS mice by fucoxanthin may be able to track with salivary glycine. In Vivo. Nov-Dec 2020;34(6):3205-3215. doi: 10.21873/invivo.12156.
YoshikawaY, Tsunematsu Y, Matsuzaki N, Hirayama Y, Higashiguchi F, Sato M, Iwashita Y, Miyoshi N, Mutoh M, Ishikawa H, Sugimura H, Wakabayashi K, Watanabe K. Characterization of colibactin-producing Escherichia coli isolated from Japanese patients with colorectal cancer. Jpn J Infect Dis. 2020 Nov 24;73(6):437-442. doi: 10.7883/yoken.JJID.2020.066.
Umemura S, Sowa Y, Iizumi Y, Kitawaki J, Sakai T. Synergistic effect of the inhibitors of RAF/MEK and AXL on KRAS-mutated ovarian cancer cells with high AXL expression. Cancer Sci. 2020 Jun;111(6):2052-2061. doi: 10.1111/cas.14414.
Chihara Y, Iizumi Y, Horinaka M, Watanabe M, Goi W, Morita M, Nishimoto E, Sowa Y, Yamada T, Takayama K, Sakai T. Histone deacetylase inhibitor OBP‑801 and amrubicin synergistically inhibit the growth of squamous cell lung carcinoma by inducing mitochondrial ASK1‑dependent apoptosis. Int J Oncol. 2020 Mar;56(3):848-856. doi: 10.3892/ijo.2020.4969.
Miyamoto K, Watanabe M*†, Boku S, Sukeno M, Morita M, Kondo H, Sakaguchi K, Taguchi T, Sakai T. xCT Inhibition increases sensitivity to vorinostat in a ROS-dependent manner. Cancers (Basel). 2020 Mar 30;12(4):827. doi: 10.3390/cancers12040827. (*equal contribution, †corresponding author)
Boku S, Watanabe M†, Sukeno M, Yaoi T, Hirota K, Iizuka-Ohashi M, Itoh K, Sakai T. Deactivation of glutaminolysis sensitizes PIK3CA-mutated colorectal cancer cells to aspirin-induced growth inhibition. Cancers (Basel). 2020 Apr 30;12(5):1097. doi: 10.3390/cancers12051097. (†corresponding author)
Yokoyama A, Katada C, Yokoyama T, Takizawa K, Yano T, Oda I, Shimizu Y, Nakanishi H, Koike T, Hirao M, Okada H, Yoshii T, Katagiri A, Yamanouchi T, Matsuo Y, Kawakubo H, Kobayashi N, Ishikawa H, Muto M. The alcohol use disorders identification test and the risk of metachronous cancer after endoscopic resection of esophageal cancer. Carcinogenesis. 2020 Aug 12;41(8):1049-1056. doi:10.1093/carcin/bgaa022
Yokoyama A, Katada C, Yokoyama T, Takizawa K, Yano T, Oda I, Shimizu Y, Nakanishi H, Koike T, Hirao M, Okada H, Yoshii T, Katagiri A, Yamanouchi T, Matsuo Y, Kawakubo H, Kobayashi N, Ishikawa H, Muto M. Association between the findings of metachronous secondary primary malignancies and the number of Lugol-voiding lesions. Dis Esophagus. 2020 Sep 4;33(9):doz110. doi: 10.1093/dote/doz110.
Yoshida N, Doyama H, Yano T, Horimatsu T, Uedo N, Yamamoto Y, Kakushima N, Kanzaki H, Hori S, Yao K, Oda I, Katada C, Yokoi C, Ohata K, Yoshimura K, Ishikawa H, Muto M. Early gastric cancer detection in high-risk patients: a multicentre randomised controlled trial on the effect of second-generation narrow band imaging. Gut. 2021 Jan;70(1):67-75. doi: 10.1136/gutjnl-2019-319631.
石川秀樹. 消化管ポリポーシス, 新臨床内科学, 2020, 573-575.
Ogawa-Ochiai K, Yoshimura K, Shirai A, Sakai S, Moriyama H, Nakamura K, Murayama T, Ishikawa H. Study protocol for daiobotanpito combined with antibiotic therapy for treatment of acute diverticulitis: a study protocol for a randomized controlled trial. Trials. 2020 Jun 16;21(1):531. doi: 10.1186/s13063-020-04370-7.
Oda I, Shimizu Y, Yoshio T, Katada C, Yokoyama T, Yano T, Suzuki H, Abiko S, Takemura K, Koike T, Takizawa K, Hirao M, Okada H, Yoshii T, Katagiri A, Yamanouchi T, Matsuo Y, Kawakubo H, Kobayashi N, Shimoda T, Ochiai A, Ishikawa H, Yokoyama A, Muto M. Long-term outcome of endoscopic mucosal resection for intramucosal esophageal squamous cell cancer: a secondary analysis of the Japan Esophageal Cohort study. Endoscopy. 2020 Nov;52(11):967-975. doi: 10.1055/a-1185-9329.
Hamada K, Kanzaki H, Inoue M, Ishiyama S, Yamauchi K, Miyahara K, Toyokawa T, Tsuzuki T, Miyaike J, Matsubara M, Takahashi S, Nishimura M, Takenaka R, Yunoki N, Hori S, Kobayashi S, Yamasaki Y, Kawahara Y, Ishikawa H, Okada H. Continued aspirin treatment may be a risk factor of delayed bleeding after gastric endoscopic submucosal dissection under heparin replacement: a retrospective multicenter study. Intern Med. 2020 Nov 1;59(21):2643-2651. doi: 10.2169/internalmedicine.4998-20.
Shinozaki T, Katada C, Shiga K, Asakage T, Yokoyama T, Yano T, Oda I, Shimizu Y, Takemura K, Ishikawa H, Yokoyama A, Muto M. Effectiveness of planned surveillance fordetecting second primary head and neck cancers after endoscopic resection of esophageal squamous cell carcinoma. Jpn J Clin Oncol. 2020 Sep 28;50(10):1162-1167. doi: 10.1093/jjco/hyaa087.
Yamada S, Fujii T, Yamamoto T, Takami H, Yoshioka I, Yamaki S, Sonohara F, Shibuya K, Motoi F, Hirano S, Murakami Y, Inoue H, Hayashi M, Murotani K, Kitayama J, Ishikawa H, Kodera Y, Sekimoto M, Satoi S, Phase I/II study of adding intraperitoneal paclitaxel in patients with pancreatic cancer and peritoneal metastasis. Br J Surg. 2020 Dec;107(13):1811-1817. doi: 10.1002/bjs.11792.
Kakushima N, Yoshida N, Doyama H, Yano T, Horimatsu T, Uedo N, Yamamoto Y, Kanzaki H, Hori S, Yao K, Oda I, Tanabe S, Yokoi C, Ohata K, Yoshimura K, Ishikawa H, Muto M. Near-focus magnification and second-generation narrow-band imaging for early gastric cancer in a randomized trial. J Gastroenterol. 2020 Dec;55(12):1127-1137. doi: 10.1007/s00535-020-01734-3.
石田秀行，近谷賢一，母里淑子，百瀬修二，長田久人，山野智基，冨田尚裕，秋山泰樹，平田敬治，六車直樹，高山哲治，西田佳弘，石川秀樹. 家族性大腸腺腫症に合併するデスモイド腫瘍の診断・治療と重症度分類の提案. 遺伝性腫瘍. 2020, 20, 245-58.
石川秀樹, 池浦司, 岡崎和一. 自己免疫性膵炎の最前線コラム(2)：IgG4関連疾患患者レジストリ, 胆と膵. 2020, 41, 10, 1031-1035.
Hamada K, Kanzaki H, Inoue M, Ishiyama S, Yamauchi K, Miyahara K, Toyokawa T, Tsuzuki T, Miyaike J, Matsubara M, Takahashi S, Nishimura M, Takenaka R, Yunoki N, Hori S, Kobayashi S, Yamasaki Y, Kawahara Y, Ishikawa H, Okada H. Continued aspirin treatment may be a risk factor of delayed bleeding after gastric endoscopic submucosal dissection under heparin replacement: a retrospective multicenter study. Intern Med. 2020 Nov 1;59(21):2643-2651. doi: 10.2169/internalmedicine.4998-20.

著書業績

2020年

Mutoh M, Narita T, Ishikawa H. Chemoprevention for Lynch Syndrome-Associated Malignancies: Lynch Syndrome. In Tomita N, Editor. Springer Publishers, Basel, Switzerland: pp123-132, 2020.
曽和義広, 酒井敏行.　「入門腫瘍内科学　改定第3版」　日本臨床腫瘍学会編集　南江堂

2021年

武藤倫弘.ひと目でわかる実装科学：がん対策実践家のためのガイド」(翻訳の全体監修)

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