1. 低分子化合物による体細胞から神経細胞：CiN細胞(chemical compound-induced neuronal cells)への直接誘導の分子メカニズムの解明
2. CiN細胞の遺伝的なキャラクタリゼーション
3. CiN細胞のin vitroまたはin vivoの機能解析
4. 低分子化合物による体細胞からのCiN細胞以外の細胞種への誘導法の開発
5. CiN細胞を用いたアルツハイマー病や筋萎縮性側索硬化症などの神経変性疾患、脊髄損傷、末梢神経障害、網膜疾患などの治療法の開発

1. Takeda Y, Yoshikawa T, Dai P. Angiotensin II participates in mitochondrial thermogenic functions via the activation of glycolysis in chemically induced human brown adipocytes. Sci. Rep., 14(1): 10789 (2024).
2. Kurahashi T, Nishime C, Nishinaka E, Komaki Y, Seki F, Urano K, Harada Y, Yoshikawa T, Dai P. Transplantation of Chemical Compound-Induced Cells from Human Fibroblasts Improves Locomotor Recovery in a Spinal Cord Injury Rat Model. Int. J. Mol. Sci.,24(18): 13853 (2023).
3. Takeda Y, Harada Y, Yoshikawa T, Dai P. Mitochondrial Energy Metabolism in the Regulation of Thermogenic Brown Fats and Human Metabolic Diseases. Int. J. Mol. Sci., 24(2): 1352 (2023).
4. Takeda Y,Dai P. Chronic Fatty Acid Depletion Induces Uncoupling Protein 1 (UCP1) Expression to Coordinate Mitochondrial Inducible Proton Leak in a Human-Brown-Adipocyte Model. Cells, 11(13): 2038 (2022).
5. Takeda Y,Dai P. Capsaicin directly promotes adipocyte browning in the chemical compound-induced brown adipocytes converted from human dermal fibroblasts. Sci. Rep., 12(1): 6612 (2022).
6. Takeda Y, Yoshikawa T, Dai P. Transcriptome analysis reveals brown adipogenic reprogramming in chemical compound-induced brown adipocytes converted from human dermal fibroblasts. Sci. Rep., 11(1): 5061 (2021).
7. Takeda Y, Dai P. A developed serum-free medium and an optimized chemical cocktail for direct conversion of human dermal fibroblasts into brown adipocytes. Sci. Rep., 10(1): 3775 (2020).
8. Takeda Y, Harada Y, Yoshikawa T, Dai P. Chemical compound-based direct reprogramming for future clinical applications. Biosci. Rep., 38(3): BSR20171650 (2018).
9. Takeda Y, Harada Y, Yoshikawa T, Dai P. Direct conversion of human fibroblasts to brown adipocytes by small chemical compounds. Sci. Rep., 7(1): 4304 (2017).
10. Dai P, Harada Y, Takamatsu T. Highly efficient direct conversion of human fibroblasts to neuronal cells by chemical compounds. J. Clin. Biochem. Nutr., 56(3): 166-170 (2015).

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