1. 低分子化合物による体細胞から神経細胞：CiN細胞(chemical compound-induced neuronal cells)への直接誘導の分子メカニズムの解明
2. CiN細胞の遺伝的なキャラクタリゼーション
3. CiN細胞を用いたアルツハイマー病や筋萎縮性側索硬化症などの神経変性疾患、脊髄損傷、末梢神経障害、網膜疾患などの治療法の開発
4. 低分子化合物による体細胞からのCiN細胞以外の細胞種への誘導法の開発
5. 低分子化合物によるヒト体細胞から褐色脂肪細胞への誘導技術の開発とその応用研究

1. Kurahashi T, Harada Y, Dai P. In Vitro Generation of Brown and Beige Adipocytes via Cellular Reprogramming. Cell Reprogram., 27 (6): 216-227 (2025).
2. Kurahashi T, Nishime C, Nishinaka E, Komaki Y, Seki F, Urano K, Harada Y, Yoshikawa T, Dai P. Transplantation of Chemically Induced Human Fibroblast-Derived Cells Enhances Functional Recovery in a Common Marmoset Model of Spinal Cord Injury. Acta Histochem Cytochem., 58(1):19-30 (2025).
3. Takeda Y, Dai P. Functional roles of pantothenic acid, riboflavin, thiamine, and choline in adipocyte browning in chemically induced human brown adipocytes. Sci. Rep., 14(1):18252 (2024).
4. Takeda Y, Yoshikawa T, Dai P. Angiotensin II participates in mitochondrial thermogenic functions via the activation of glycolysis in chemically induced human brown adipocytes. Sci. Rep., 14(1): 10789 (2024).
5. Kurahashi T, Nishime C, Nishinaka E, Komaki Y, Seki F, Urano K, Harada Y, Yoshikawa T, Dai P. Transplantation of Chemical Compound-Induced Cells from Human Fibroblasts Improves Locomotor Recovery in a Spinal Cord Injury Rat Model. Int. J. Mol. Sci.,24(18): 13853 (2023).
6. Takeda Y, Harada Y, Yoshikawa T, Dai P. Mitochondrial Energy Metabolism in the Regulation of Thermogenic Brown Fats and Human Metabolic Diseases. Int. J. Mol. Sci., 24(2): 1352 (2023).
7. Takeda Y,Dai P. Chronic Fatty Acid Depletion Induces Uncoupling Protein 1 (UCP1) Expression to Coordinate Mitochondrial Inducible Proton Leak in a Human-Brown-Adipocyte Model. Cells, 11(13): 2038 (2022).
8. Takeda Y,Dai P. Capsaicin directly promotes adipocyte browning in the chemical compound-induced brown adipocytes converted from human dermal fibroblasts. Sci. Rep., 12(1): 6612 (2022).
9. Takeda Y, Yoshikawa T, Dai P. Transcriptome analysis reveals brown adipogenic reprogramming in chemical compound-induced brown adipocytes converted from human dermal fibroblasts. Sci. Rep., 11(1): 5061 (2021).
10. Takeda Y, Dai P. A developed serum-free medium and an optimized chemical cocktail for direct conversion of human dermal fibroblasts into brown adipocytes. Sci. Rep., 10(1): 3775 (2020).
11. Takeda Y, Harada Y, Yoshikawa T, Dai P. Chemical compound-based direct reprogramming for future clinical applications. Biosci. Rep., 38(3): BSR20171650 (2018).
12. Takeda Y, Harada Y, Yoshikawa T, Dai P. Direct conversion of human fibroblasts to brown adipocytes by small chemical compounds. Sci. Rep., 7(1): 4304 (2017).
13. Dai P, Harada Y, Takamatsu T. Highly efficient direct conversion of human fibroblasts to neuronal cells by chemical compounds. J. Clin. Biochem. Nutr., 56(3): 166-170 (2015).

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