大学院科目名 | 歯科口腔科学 | ||
医学部教室名 | |||
スタッフ |
病院准教授 山本 俊郎
助教(学内講師)大迫 文重 助教 足立 圭司 助教 小野 龍太郎
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研究内容 |
医科大学のなかの歯科という特色を生かし「全身疾患と口腔との関係について」を主な研究テーマに掲げ、歯科のみならず他の教室と共同研究を行っている。
基礎分野では、「歯内・歯周領域の疾患に対する病態解明」について免疫学、感染病態学、運動器機能再生外科学と、「口腔内細菌と脳内微小出血に関する疫学的検討や口腔機能低下症と全身に関する検討」について地域保健医療疫学と、「歯の形成と体内時計」について統合生理学と共同研究を実施している。
臨床分野では、「羊膜を用いた口腔外科領域の疾患」に対する再生医療について視覚機能再生外科学と、「歯周病と糖尿病の関係」について内分泌・代謝内科と、「口腔細菌と川崎病の関係」について細胞分子機能制御学と共同研究を実施している。
再生医療では、羊膜上口腔粘膜培養上皮シートを作成、手術後の上皮欠損症例に対し臨床応用が行われ、良好な成績をおさめている。また歯周病と糖尿病に関しては、糖尿病患者に対し歯周病治療を行うことで、血糖コントロールの改善がみられている。
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研究業績 |
1. Adachi T, Tahara Y, Yamamoto K, Yamamoto T, Kanamura N, Akiyoshi K, Mazda O. Cholesterol-bearing Polysaccharide-based nanogels for development of novel immunotherapy and regenerative medicine. Gels 10: 206, 2024.
2. Ono R, Katsumata A, Fujikawa Y, Takahira E, Yamamoto T, Kanamura N. Sex differences and age-related changes in the mandibular alveolar bone mineral density using a computer-aided measurement system for intraoral radiography. Sci Rep 2024.
3. Ono R, Kano M, Fujikawa Y, Yamamoto T, Kanamura N.Elevated alveolar bone mineral density in female patients undergoing bisphosphonate therapy: A pilot cross-sectional study using intraoral radiographs. Oral Sci Int 2024.
4. Yamamoto Y, Yamamoto T, Miyamoto N, Kinoshita K, Nishikawa S, Adachi T, Takizawa S, Inoue R, Matoba S, Kanamura N. Oral function and the oral microbiome in the elderly in the Kyotango area. Dent J 12: 16, 2024.
5. Ono R, Amemiya T, Yamamoto T, Kanamura N. Successful conservative management of pathological mandibular fracture resulting from chronic osteomyelitis in a 90‐year‐old woman. Oral Sci Int 20: 42-47, 2023.
6. Yamanobe H, Yamamoto K, Kishimoto S, Nakai K, Oseko F, Yamamoto T, Mazda O, Kanamura N. Anti-inflammatory effects of beta-cryptoxanthin on 5-Fluorouracil-induced cytokine expression in human oral mucosal keratinocytes. Molecules 28: 2935, 2023.
7. Adachi T, Miyamoto N, Imamura H, Yamamoto T, Marin E, Zhu W, Kobara M, Sowa Y, Tahara Y, Kanamura N, Akiyoshi K, Mazda O, Nishimura I, Pezzotti G. Three-dimensional culture of cartilage tissue on nanogel-cross-linked porous freeze-dried gel scaffold for regenerative cartilage therapy: A vibrational spectroscopy evaluation. Int J Mol Sci 23: 8099, 2022.
8. Raman analyses of laser irradiation-induced microstructural variations in synthetic hydroxyapatite and human teeth. J Funct Biomater 13: 200, 2022.
9. Adachi K, Yamamoto T, Kishimoto S, Takizawa S, Oseko F, Kanamura N. A patient with large congenital epulis in the maxillary and mandibular anterior areas accompanied by impaired suckling. Oral Sci Int 19: 205-210, 2022.
10. Nakai K, Yamamoto K, Kishida T, Kotani SI, Sato Y, Horiguchi S, Yamanobe H, Adachi T, Boschetto F, Marin E, Zhu W, Yamamoto T, Kanamura N, Pezzotti G, Mazda O. Osteogenic response to polysaccharide nanogel sheets of human fibroblasts after conversion into functional osteoblasts by direct phenotypic cell reprogramming. Front Bioeng Biotechnol 9: 713932, 2021.
11. Ono R, Abe M, Koike N, Inokawa H, Tsuchiya Y, Umemura Y, Yuh Sasawaki, Yamamoto T, Wakisaka S, Kanamura N, Yagita K. Quantitative morphometric analysis of molar teeth and alveolar bone using micro-computed tomography in aged mice. J Oral Biosci 63: 265-270, 2021.
12. Nakagawa M, Shirasugi M, Yamamoto T, Nakaya T, Kanamura N.Long-term exposure to butyric acid induces excessive production of matrix metalloproteases in human gingival fibroblasts.Arch Oral Biol 12: 105035, 2021.
13. Okui M, Murakami T, Sun H, Ikeshita C, Kanamura N, Taruno A. Post-translational regulation of CALHM1/3 channel: N-linked glycosylation and S-palmitoylation. FASEB J 35: e21527, 2021.
14. Nakamura K, Yamamoto T, Ema R, Nakai K, Sato Y, Yamamoto Y, Yamamoto K, Adachi K, Kanamura N. Effects of mechanical stress on human oral mucosa-derived cells.Oral Dis 27: 1184-1192, 2021.
15. Yamamoto T, Takizawa S, Otsubo M, Ema R, Oyabu M, Sato Y, Nakao E, Matsuzawa N, Adachi T, Adachi K, Oseko F, Yamamoto Y, Kanamura N. Clinical study of anti-resorptive agents-related osteonecrosis of the jaw in prostate cancer patients using the bone-modifying agents injection in our hospital. Journal of Japanese Society of Dentistry for Medically Compromised Patient 29: 298-304, 2020.
16. Miyamoto N, Adachi T, Boschetto F, Zanocco M,Yamamoto T, Marin E, Somekawa S, Ashida R, Zhu W, Kanamura N, Nishimura I, Pezzotti G. Molecular fingerprint imaging to identify dental caries using raman spectroscopy. Materials (Basel) 13: 4900, 2020.
17. Adachi T, Boschetto F, Miyamoto N, Yamamoto T, Marin E, Zhu W, Kanamura N, Tahara Y, Akiyoshi K, Mazda O, Nishimura I, Pezzotti G. In vivo regeneration of large bone defect by cross-linked porous hydrogel: a combined study by micro-tomography, histological analyses, Raman spectroscopy and synchrotron infrared imaging.Materials (Basel) 13: 4275, 2020.
18. Ono R, Koike N, Inokawa H, Tsuchiya Y, Umemura Y, Yamamoto T, Kanamura N, Yagita K. Incremental growth lines in mouse molar dentin represent 8-hr ultradian rhythm. Acta Histochem Cytochem 52: 93-99, 2019.
19. Iwai K, Watanabe I, Yamamoto T, Kuriyama N, Matsui D, Nomura R, Ogaya Y, Oseko F, Adachi K, Takizawa S, Ozaki E, Koyama T, Nakano K, Kanamura N, Uehara R, Watanabe Y. Association between Helicobacter pylori infection and dental pulp reservoirs in Japanese adults. BMC Oral Health 19: 267, 2019.
20.Takizawa S, Yamamoto T, Honjo KI, Sato Y, Nakamura K, Yamamoto K, Adachi T, Uenishi T, Oseko F, Amemiya T, Yamamoto Y, Kumagai W, Kita M, Kanamura N. Transplantation of dental pulp-derived cell sheets cultured on human amniotic membrane induced to differentiate into bone. Oral Dis 25: 1352-1362, 2019.
21. Horiguchi S, Adachi T, Rondinella A, Boschetto F, Marin E, Zhu W, Tahara Y, Yamamoto T, Kanamura N, Akiyoshi K, Pezzotti G, Mazda O. Osteogenic response of mesenchymal progenitor cells to natural polysaccharide nanogel and atelocollagen scaffolds: A spectroscopic study. Mater Sci Eng C Mater Biol Appl 99: 1325-1340, 2019.
22. Yamamoto T, Takizawa S, Otsubo M, Miyagaki Y, Matsui D, Iehara T, Kanamura N. Effects of oral care on perioperative pediatric cancer patients. Dent Oral Craniofac Res 5: 1-6, 2019.
23. Shirahase T, Watanabe Y, Tsujimura A, Kwak S, Yamamoto T, Kanamura N, Tanaka M. Ethanol Preference and Drinking Behavior Are Controlled by RNA Editing in the Nucleus Accumbens. Front Behav Neurosci 12: 331, 2019.
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問い合わせ先 | TEL:075-251-5641 FAX:075-251-5641 e-mail:yamamoto@koto.kpu-m.ac.jp |
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教室独自のHP | なし |