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呼吸器外科学／外科学教室（呼吸器外科学部門）

 呼吸器外科HP　http://www.f.kpu-m.ac.jp/k/thoracic/ 　

大学院科目名 呼吸器外科学
医学部教室名 外科学教室（呼吸器外科学部門）
スタッフ
教授　　井上　匡美
  
准教授　　　下村　雅律
学内講師　　岡田　悟
助教　　　　古谷　竜男
 
研究内容
・悪性胸腺上皮性腫瘍のPD-1・PD-L1作用に関する病態解明と新たな免疫療法の開発
・原発性肺癌におけるSpread Through Air Spaceの分子病態解明
・患者由来がん組織を培養可能なデバイスの開発とがん免疫療法の評価法の構築
・肺癌のパクリタキセル耐性に関わる関連タンパク質の同定とその機能解明
・ラット開胸モデルを用いた血小板活性抑制による癒着防止効果の検証
・がん微小環境に着眼した肺癌に対する栄養療法の抗腫瘍効果の解明
・胸部悪性腫瘍のCTOS法確率と分子病理学的解析
・肺癌組織を用いた電子顕微鏡による肺癌細胞の極性異常の解析
研究業績
  1. Inoue M, Yamamoto H, Okada Y, Sato T, Sato Y, Suzuki K, Yoshino I, Chida M; Japanese Association of Chest Surgery. Perioperative outcomes of minimally invasive surgery for large malignant thymic epithelial tumors and for total thymectomy. Surg Today. 53(9):1089-1099, 2023.
  2. Shimomura M, Miyagawa-Hayashino A, Omatsu I, Asai Y, Ishihara S, Okada S, Konishi E, Teramukai S, Inoue M. Spread through air spaces is a powerful prognostic predictor in patients with completely resected pathological stage I lung adenocarcinoma. Lung Cancer. 174 (12): 165-171, 2022
  3. Shimomura M, Ishihara S, Okada S, Inoue M. Robotic Subxiphoid-optical Thymectomy. Interact Cardiovasc Thorac Surg. 35(2):ivac104, 2022.
  4. Okada S, Shimomura M, Ishihara S, Ikebe S, Furuya T, Inoue M. Clinical significance of postoperative pulmonary complications in elderly patients with lung cancer. Interact Thorac Cardiovasc Surg. 35(2): ivac153, 2022.
  5. Ishihara S, Shimomura M, Tsunezuka H, Ikebe S, Inoue M. Robot-assisted thoracoscopic surgery for large apical schwannoma in an obese patient. Gen Thorac and Cardiovasc Surg Cases. 1:8, 2022.
  6. Furuya T, Ishihara S, Ogi H, Masuda K, Shibata S, Nakazono C, Okada S, Shimomura M, Tando S, Yaoi T, Maeda Y, Yamagishi M, Kawamoto H, Itoh K, Inoue M. Characteristic differences in the abundance of tumor-infiltrating lymphocytes and intratumoral developing T cells in thymoma, with special reference to PD-1 expression. Cancer Immunol Immunother. 72(8):2585-2596, 2023.
  7. Matsuura Y, Nishimura M, Furuichi K, Hirohashi R, Teramukai S, Shimada J, Inoue M Clinical significance of spread of lipiodol marking for pulmonary nodules and its influence on surgery Gen Thorac Cardiovasc Surg. 70(12):1015-1021, 2022.
  8. Küffer S, Grabowski J, Okada S, Sojka N, Welter S, von Hammerstein-Equord A, Hinterthaner M, Cordes L, von Hahn X, Müller D, Sauer C, Bohnenberger H, Marx A, Ströbel P. Phosphoproteomic Analysis Identifies TYRO3 as a Mediator of Sunitinib Resistance in Metastatic Thymomas. Cancers (Basel). 14(19): 4762, 2022.
  9. Shimomura M, Iwasaki M, Shimegi R, Inoue M. Life-threatening extrapleural hematoma in an anticoagulated patient 2 weeks after lobectomy. Thoracic cancer, 12(21):2953-2955, 2021.
  10. Okada S, Hattori A, Matsunaga T, Takamochi K, Oh S, Inoue M, Suzuki K. Prognostic Value of Visceral Pleural Invasion in Pure-Solid and Part-solid Lung Cancer Patients. Gen Thorac Cardiovasc Surg. 69(2):303-310, 2021.
  11. Miyagawa-Hayashino A, Okada S, Takeda-Miyata N, Takashima Y, Yamada T, Takemura Y, Uchino J, Inoue M, Takayama K, Konishi E. TTF-1 and c-MYC-defined phenotypes of large cell neuroendocrine carcinoma and delta-like protein 3 expression for treatment selection. Appl Immunohistochem Mol Morphol, 29(4): 313-20, 2021.
  12. Shimomura M, Sowa Y, Yamochi R, Inoue M.Extended latissimus dorsi chimeric thoracoplasty with a vascular supercharge for Aspergillus empyema.Interactive cardiovascular and thoracic surgery. 30(3), 491-2,2020.
  13. Okada S, Shimomura M, Tsunezuka H, Ishihara S, Ishikawa N, Kameyama K, Kitaoka S, Inoue M. One-stage closure of large bronchopleural fistula with pedicled latissimus dorsi muscle flap after preemptive antibiotics: A case report. Int J Surg Case Rep. 74: 257-259,2020.
  14. Okada S, Inoue M.ASO Author Reflections: High neutrophil count as a negative prognostic factor for relapse in patients with thymic epithelial tumor. Ann Surg Oncol. 2020 Jul; 27(7): 2448-2449.
  15. Okada S, Shimomura M, Tsunezuka H, Ishihara S, Ikebe S, Furuya T, Shimada J, Teramukai S, Inoue M. High neutrophil count as a negative prognostic factor for relapse in patients with thymic epithelial tumor. Ann Surg Oncol. 27(7): 2438-2447,2020.
  16. Okada S, Miyagawa-Hayashino A, Sonobe Y, Inoue M. Isolated diaphragmatic metastasis originating from early endometrial cancer. Ann Thorac Surg. 110(1): e27-e29,2020.
  17. Okada S, Miyagawa-Hayashino A, Fujinami J, Nishimura T, Ishikawa N, Tsunezuka H, Shimomura M, Shimada J, Inoue M. Trousseau’s syndrome associated with pulmonary pleomorphic carcinoma showing aggressive features: a case report. Mol Clin Oncol. 12(1): 36-40,2020.
  18. Takeda-Miyata N, Konishi E, Tanaka T, Shimomura M, Tsunezuka H, Okada S, Ishihara S, Ishikawa N, Inoue M.Prognostic significance of spread through air spaces in pulmonary metastases from colorectal cancer. Lung Cancer. 149: 61-67,2020
  19. Ito K, Shimada J, Shimomura M, Terauchi K, Nishimura M, Yanada M, Iwasaki Y, Ueshima Y, Kato D, Suzuki H, Inoue M. Safety and reliability of computed tomography-guided lipiodol marking for undetectable pulmonary lesions. Interact Cardiovasc Thorac Surg. 30(4): 546-551, 2020. 
  20. Tsunezuka H, Nakamura T, Fujikawa K, Shimomura M, Okada S, Shimada J, Teramukai S, Ukimura O, Inoue M. Prediction models for the viability of pulmonary metastatic lesions after chemotherapy in nonseminomatous germ cell tumors. Int J Urol. 27(3): 206-212, 2020. 
  21. Okada S, Shimomura M, Tsunezuka H, Teramukai S, Ishihara I, Shimada J, Inoue M. Prognostic significance of perioperative C-reactive protein in resected non-small cell lung cancer. Semin Thorac Cardiovasc Surg. 2020 May 10. [Epub ahead of print] 
  22. Okada S, Inoue M. Clinical significance of peripheral blood inflammatory markers in thymic epithelial tumors. Ann Surg Oncol. 2020 Mar 20. [Epub ahead of print] 
  23. Okada S, Shimomura M, Tsunezuka H, Ishihara S, Ikebe S, Furuya T, Shimada J, Teramukai S, Inoue M. High neutrophil count as a negative prognostic factor for relapse in patients with thymic epithelial tumor. Ann Surg Oncol. 2020 Jan 29. [Epub ahead of print] 
  24. Ishihara S, Okada S, Ogi H, Kodama Y, Shimomura M, Tsunezuka H, Itoh K, Marx A, Inoue M. Programmed death-ligand 1 expression profiling in thymic epithelial cell tumors: clinicopathological features and the quantitative digital image analyses. Lung Cancer. 145: 40-47, 2020.
  25. Inoue M, Kusumoto H, Shiono H, Shintani Y, Ose N, Sakamaki Y, Okami J, Higashiyama M, Takeuchi Y. Feasibility of postoperative adjuvant chemotherapy using carboplatin plus S-1 in completely resected non-small cell lung cancer patients. J Chemother. 31: 343-348, 2019. 
  26. Shimomura M, Ishihara S, Iwasaki M, Inoue M. Volume-Based Consolidation-Tumor Ratio Is a Useful Predictor for Postoperative Upstaging In Stage I and II Lung Adenocarcinoma. Thorac cardiovasc Surg. 2019 Aug 8. [Epub ahead of print] 
  27. Tsunezuka H, Inoue M. Treatment rationale and design of the induction chemotherapy and adjuvant thoracic radiation in resectable N2-3A/3B non-small cell lung cancer (ICAT) study. Medicine (Baltimore). 98: e16298, 2019.  
  28. Okada S, Shimada J, Kato D, Tsunezuka H, Teramuka S, Inoue M. Long-term prognostic impact of severe postoperative complications after lung cancer surgery. Ann Surg Oncol. 26: 230-237, 2019. 
  29. Ishihara S, Ito K, Okada S, Shimomura M, Shimada J, Yamaguchi T, Inoue M. Suppressive effects of aspirin for postthoracotomy pleural adhesion in rats. Int J Med Sci. 16: 593-601, 2019.  
  30. Furuya T, Ii T, Yanada M, Toda S. Early chest tube removal after surgery for primary spontaneous pneumothorax. Gen Thorac Cardiovasc Surg. 67: 794-799, 2019. 
  31. Yoshimura A, Yamada T, Miyagawa-Hayashino A, Sonobe Y, Imabayashi T, Yamada T, Okada S, Shimamoto T, Chihara T, Iwasaku M, Kaneko Y, Uchino J, Inoue M, Konishi E, Takayama K. Comparing Three Different Anti-PD-L1 Antibodies for Immunohistochemical Evaluation of Small Cell Lung Cancer. Lung Cancer. 137: 108-112, 2019. 
  32. Sakakida T, Ishikawa T, Uchino J, Chihara Y, Komori S, Asai J, Narukawa T, Arai A, Kobayashi T, Tsunezuka H, Kosuga T, Konishi H, Hongo F, Inoue M, Hirano S, Ukimura O, Itoh Y, Taguchi T, Takayama K. Clinical features of immune-related thyroid dysfunction and its association with outcomes in patients with advanced malignancies treated by PD-1 blockade. Oncol Lett. 18: 2140-2147, 2019. 
  33. Inoue M, Maeda H, Takeuchi Y, Fukuhara K, Shintani Y, Funakoshi Y, Funaki S, Nojiri T, Kusu T, Kusumoto H, Kimura T, Okumura M; Representing the Thoracic Surgery Study Group of Osaka University. Collagen gel droplet-embedded culture drug sensitivity test for adjuvant chemotherapy after complete resection of non-small-cell lung cancer. Surg Today. 48: 380-387, 2018. 
  34. Okada S, Shimada J, Teramukai S, Kato D, Tsunezuka H, Miyata N, Ishihara S, Furuya T, Nakazono C, Ishikawa N, Inoue M. Risk stratification according to the prognostic nutritional index for predicting postoperative complications after lung cancer surgery. Ann Surg Oncol. 25: 1254-1261, 2018. 
  35. Okada S, Itoh K, Ishihara S, Shimada J, Kato D, Tsunezuka H, Miyata N, Hirano S, Teramukai S, Inoue M. Significance of PD-L1 expression in pulmonary metastases from head and neck squamous cell carcinoma. Surg Oncol. 27: 259-265, 2018. 
  36. Okada S, Ito K, Shimada J, Kato D, Shimomura M, Tsunezuka H, Miyata N, Ishihara S, Furuya T, Inoue M. Clinical application of postoperative non-invasive positive pressure ventilation after lung cancer surgery. Gen Thorac Cardiovasc Surg. 66: 565-572, 2018. 
  37. Ose N, Maeda H, Inoue M, Morii E, Shintani Y, Matsui H, Tada H, Tokunaga T, Kimura K, Sakamaki Y, Takeuchi Y, Fukuhara K, Katsura H, Iwasaki T, Okumura M; Thoracic Surgery Study Group of Osaka University. Results of treatment for thymic neuroendocrine tumours: multicentre clinicopathological study. Interact Cardiovasc Thorac Surg. 26: 18-24, 2018. 
  38. Oji Y, Inoue M, Takeda Y, Hosen N, Shintani Y, Kawakami M, Harada T, Murakami Y, Iwai M, Fukuda M, Nishida S, Nakata J, Nakae Y, Takashima S, Shirakata T, Nakajima H, Hasegawa K, Kida H, Kijima T, Morimoto S, Fujiki F, Tsuboi A, Morii E, Morita S, Sakamoto J, Kumanogoh A, Oka Y, Okumura M, Sugiyama H. WT1 peptide-based immunotherapy for advanced thymic epithelial malignancies. Int J Cancer. 142: 2375-2382, 2018. 
  39. Tsunezuka H, Kato D, Okada S, Furuya T, Shimada J, Inoue M. Surgical outcome of wide wedge resection in poor risk patients with clinical-n0 non-small cell lung cancer. Gen Thorac Cardiovasc Surg. 10: 581-586, 2017. 
  40. Okada S, Shimada J, Kato D, Tsunezuka H, Teramukai S, Inoue M. Clinical Significance of Prognostic Nutritional Index After Surgical Treatment in Lung Cancer. Ann Thorac Surg. 104: 296-302, 2017. 
  41. Okada S, Shimada J, Kato D, Tsunezuka H, Inoue M. Prolonged air leak following lobectomy can be predicted in lung cancer patients. Surg Today. 47: 973-979, 2017. 
  42. Okada S, Shimada J, Ito K, Ishii T, Oshiumi K. Surface-processing technology of a microgrooving and water-repellent coating improves the fusion potential of an ultrasonic energy device. Surg Endosc. 31: 887-893, 2017. 
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