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精神機能病態学/精神医学教室

精神機能病態学HP https://kpum-psyche.com/

大学院科目名 精神機能病態学
医学部教室名 精神医学教室
スタッフ
教授       成本 迅
准教授      富永 敏行
講師       中前 貴
講師       綾仁 信貴
助教(学内講師) 飯田 直子
助教       渡辺 杏里
助教       桑原 明子
助教       中嶋 義幸
助教       大矢 希
助教       加藤 佑佳
講師(併任)   吉井 崇喜
講師(併任)   柴田 敬祐
助教(学内講師)(併任)中村 佳永子
助教(併任)   小野 淳子
助教(併任)   松本 佳大
助教(併任)   林田 圭祐
研究内容
当教室では、種々の精神疾患の病態解明や新たな治療法の開発に向けて、以下のような臨床研究や基礎研究を行っています。
 
【臨床研究】
•摂食障害患者の精神病理や社会機能に関する臨床研究
•注意欠陥多動性障害の薬物療法終結に関する臨床研究
•認知症性疾患や老年期うつ病、老年期幻覚妄想等を対象とした、神経心理学的・ニューロイメージング手法を用いた臨床研究

•高齢者の意思決定支援、経済活動支援、詐欺被害に関する臨床研究

•強迫症に対する新規薬物療法に関する臨床研究

•精神科患者の治療へのアドヒアランスや、治療における医師患者関係に関する研究

•精神科入院患者や高齢者施設入居者における薬剤性有害事象と薬剤関連エラーの臨床疫学研究など
•精神科入院患者における円滑な治療の妨げとなる粗暴行為と違反行為の臨床疫学研究

•電気けいれん療法に伴う有害事象に関する臨床疫学研究
・電気けいれん療法後の体温変化と有効性に関する研究
・ニューロモデュレーションと認知的柔軟性との関連に関する研究
・非自発的入院に関する研究
•コンサルテーション・リエゾンにおける周術期の精神症状と適切な介入方法についての臨床疫学研究など
•身体症状症および関連症郡に対するグループ認知行動療法の効果の実証
・身体症状症関連群に遠隔・集団認知行動療法は効くか?- VRを用いた探求- 
 
【基礎研究】
• 遺伝的うつ病モデルやPTSDストレスモデルなどの動物モデルを用いた神経画像および組織学的研究
 
研究業績
Takanobu Yoshii, Naoya Oishi, Yasutaka Sotozono, Anri Watanabe, Yuki Sakai, Shunji Yamada, Ken-Ichi Matsuda, Masamitsu Kido, Kazuya Ikoma, Masaki Tanaka, Jin Narumoto. Validation of Wistar-Kyoto rats kept in solitary housing as an animal model for depression using voxel-based morphometry. Scientific reports. 2024. https://doi.org/10.1038/s41598-024-53103-2
 
Yoshihiro Matsumoto, Nobutaka Ayani, Nozomu Oya, Riki Kitaoka, Anri Watanabe, Hiroko Yoshii, Yuichi Kitaura, Shinichiro Inoue, Jin Narumoto. Frequency and predictors of perioperative psychiatric symptom worsening in patients with schizophrenia spectrum disorders.General Hospital Psychiatry. 2023:87:148-150. doi: 10.1016
 
Ken Kurisu, Nobuhiro Nohara, Shuji Inada, Makoto Otani, Haruko Noguchi, Yuka Endo, Yasuhiro Sato, Shin Fukudo, Michiko Nakazato, Tsuneo Yamauchi, Tomoko Harada, Koki Inoue, Tomokazu Hata, Shu Takakura, Nobuyuki Sudo, Naoko Iida, Yuki Mizuhara, Yoshihisa Wada, Tetsuya Ando & Kazuhiro Yoshiuchi. Economic costs for outpatient treatment of eating disorders in Japan. Journal of Eating Disorders. 2023. DOI https://doi.org/10.1186/s40337-023-00864-2
 
Naoko Iida, Junko Ono, Yuki Mizuhara , Jin Narumoto. The subjective assessment of work and social adjustment impairments and associated psychopathologies in Japanese adult female patients with anorexia nervosa. PCN Reports. 2023. DOI: 10.1002/pcn5.151
 
Imai A, Matsuoka T, Narumoto J. Emotional Dysregulation in Mild Behavioral Impairment Is Associated with Reduced Cortical Thickness in the Right        Supramarginal Gyrus. J Alzheimers Dis. 2023. doi: 10.3233/JAD-220948.    Epub ahead of print. PMID: 37038811.
 
Teruyuki Matsuoka MD, PhD.  Ayu Imai MD. Jin Narumoto MD, PhD. Neuroimaging of mild behavioral impairment: A systematic review. Psychiatry and Clinical Neurosciences Reports. 2023. doi: 10.1002/pcn5.81
 
Ayu Imai,Teruyuki Matsuoka,Jin Narumoto. Older people with severe loneliness have an atrophied thalamus, hippocampus, and entorhinal
cortex. International geriatric psychiatry. 2022 Nov 12;37(12). doi: 10.1002/gps.5845.
 
Matsuoka T, Imai A, Narumoto J. Pineal volume reduction as the neural correlate of very late-onset schizophrenia-like psychosis. Asian Journal
of Psychiatry. 2022 Sep 5;77:103251. doi: 10.1016/j.ajp. 2022.103251.
 
Ueno D, Arakawa M, Fujii Y, Amano S, Kato Y, Matsuoka T, Narumoto J. Psychosocial characteristics of victims of special fraud among Japanese
older adults: A cross-sectional study using scam vulnerability scale. Front in Psychol. 2022; 13: 960442.
 
Nobutaka Ayani, Nozomu Oya, Riki Kitaoka, Akiko Kuwahara, Takeshi Morimoto, Mio Sakuma, Jin Narumoto. Epidemiology of adverse drug
events and medication errors in four nursing homes in Japan: the Japan Adverse Drug Events (JADE) Study. BMJ Quality & Safety. 2022 Apr 21;bmjqs-2021-014280. doi: 10.1136/bmjqs-2021-014280.
 
Matsuoka T, Ueno U, Ismail Z, Rubinstein E, Uchida H, Mimura M, and Narumoto J. Neural Correlates of Mild Behavioral Impairment: A
Functional Brain Connectivity Study Using Resting-State Functional
Magnetic Resonance Imaging. J Alzheimers Dis 83(3): 1221-1231,
2021. doi: 10.3233/JAD-210628. 
 
Yoshii T. The Role of the Thalamus in Post-Traumatic Stress Disorder.
Int J Mol Sci 22(4): 1730, 2021. doi: 10.3390/ijms22041730. 
 
Ayani N, Matsuoka T, Yamano S, and Narumoto J. Depression Relapse
during Long-Term Remission due to Media-Amplified Fear during the
COVID-19 Pandemic. Case Rep Psychiatry 1-3, 2021. doi: 10.1155/2021/5682611. 
 
Kato Y, Matsuoka T, Eguchi Y, Iiboshi K, Koumi H, Nakamura K, Okabe K, Nakaaki S, Furukawa TA, Mimura M, and Narumoto J. Anxiety
Impacts Consent Capacity to Treatment in Alzheimer’s Disease. Front
Psychol 12: 685430, 2021. doi: 10.3389/fpsyg.2021.685430. 
 
Ueno D, Daiku Y, Eguchi Y, Iwata M, Amano S, Ayani N, Nakamura K, Kato Y, Matsuoka T, Narumoto J. Mild Cognitive Decline Is a Risk Factor for
Scam Vulnerability in Older Adults. Front Psychiatry 12: 685451, 2021.
doi: 10.3389/fpsyt.2021.685451. eCollection 2021. 
 
Sun W, Matsuoka T, and Narumoto J. Decision-Making Support for People with Alzheimer’s Disease: A Narrative Review. Front Psychol 12: 1-10,
2021. doi: 10.3389/fpsyg.2021.750803. 
 
Sun W, Matsuoka T, Imai A, Oya N, and Narumoto J. Effects of Hearing Impairment, Quality of Life and Pain on Depressive Symptoms in
Elderly People:A Cross-Sectional Study. Int J Env Res Pu He 18: 1-8,
2021. doi: 10.3390/ijerph182212265. 
 
Oba H, Matsuoka T, Kato Y, and Narumoto J. Attitude toward dementia and preferences for diagnosis in Japanese health service consumers. BMC
Health Serv Res 21(411): 1-7, 2021. doi: 10.1186/s12913-021-
06381-9. 
 
Oba H, Kadoya Y, Okamoto H, Matsuoka T, Abe Y, Shibata K, Narumoto J. The Economic Burden of Dementia: Evidence from a Survey of
Households of People with Dementia and Their Caregivers. Int J
Environ Res Public Health 18(5):2717, 2021. doi: 10.3390/ijerph18052717. 
 
Piras F, Piras F, Abe Y, Agarwal SM, Anticevic A, Ameis S, Arnold P, Banaj N, Bargalló N, Batistuzzo MC, Benedetti F, Beucke JC, Boedhoe PSW,
Bollettini I, Brem S, Calvo A, Cho KIK, Ciullo V, Dallaspezia S, Dickie
E, Ely BA, Fan S, Fouche JP, Gruner P, Gürsel DA, Hauser T, Hirano Y, Hoexter MQ, Iorio M, James A, Reddy YCJ, Kaufmann C, Koch K,
Kochunov P, Kwon JS, Lazaro L, Lochner C, Marsh R, Nakagawa A,
Nakamae T, Narayanaswamy JC, Sakai Y, Shimizu E, Simon D,
Simpson HB, Soreni N, Stämpfli P, Stern ER, Szeszko P, Takahashi J, Venkatasubramanian G, Wang Z, Yun JY; ENIGMA OCD Working
Group, Stein DJ, Jahanshad N, Thompson PM, van den Heuvel OA,
Spalletta G. White matter microstructure and its relation to clinical
features of obsessive-compulsive disorder: findings from the ENIGMA
OCD Working Group. Transl psychiatry 11(1): 173, 2021. doi: 10.1038/s41398-021-01276-z. 
 
Kishimoto T, Kinoshita S, Bun S, Sato Y, Kitazawa M, Kikuchi T, Sado M, Takamiya A, Mimura M, Nakamae T, Abe Y, Kanazawa T, Kawabata Y,
Tomita H, Abe K, Hishimoto A, Asami T, Suda A, YosWatanabe Y,
Amagai T, Sakuma K, Kida H, Funayama M, Kimura H, Sato A,
Fujiwara S, Nagao K, Sugiyama N, Takamiya M, Kodama H,
Azekawa T. Japanese project for telepsychiatry evaluation during
COVID-19: Treatment comparison trial (J-PROTECT): Rationale, design, and methodology. Contemp clin trials: 106596, 2021. doi: 10.1016/j.cct.2021.106596.
 
Ayani N, Morimoto T, Sakuma M, Kikuchi T, Watanabe K, Narumoto J. Antipsychotic polypharmacy is associated with adverse drug events
in psychiatric inpatients: The Japan Adverse Drug Events (JADE) Study. Journal of Clinical Psychopharmacology.Jul-Aug 01; 41(4): 397-402,
2021. doi:10.1097/JCP.0000000000001416.
 
Matsumoto Y, Nakamae T, Abe Y, Watanabe A, Narumoto J. Duration of untreated illness of patients with obsessive-compulsive disorder in
Japan. Early intervention in psychiatry 2020; 1-6. doi: 10.1111/
eip.13105.
 
Ueno D, Matsuoka T, Kato Y, Ayani N, Maeda S, Takeda M, Narumoto J. Individual differences in interoceptive accuracy are correlated with
salience network connectivity in older adults. Front Aging Neurosci
12: 592002, 2020. doi: 10.3389/fnagi.2020.592002.
 
Omichi C, Ayani N, Oya N, Matsumoto Y, Tanaka M, Morimoto T, Kadotani H, Narumoto J. Association between discontinuation of benzodiazepine
receptor agonists and post-operative delirium among inpatients with
liaison intervention: A retrospective cohort study. Compr Psychiatry
95: 152138, 2020. doi: 10.1016/j.comppsych.2020.152216.
 
Matsuoka T, Oya N, Yokota H, Akazawa K, Yamada K, Narumoto J; Alzheimer’s Disease Neuroimaging Initiative. Pineal volume
reduction in patients with mild cognitive impairment who converted
to Alzheimer’s disease. Psychiatry Clin Neurosci. 2020 Nov;74(11):
587-593.
 
Sun W, Matsuoka T, Oba H, Narumoto J. Importance of loneliness in behavioral and psychological symptoms of dementia. Int J Geriatr Psychiatry. 2020 Oct 22. doi: 10.1002/gps.5450. Epub ahead of
print.
 
Matsuoka, T., Kato, Y., Shibata, K., et al.:Importance of long-term involvement for older people living in severe squalor: A case report.
Asian J Psychiatr. 2020 Aug;52:102146.
 
Matsumoto Y, Ayani N, Kitabayashi Y, Narumoto J. New-onset mania in an elderly patient five months after acoustic neuroma resection. Bipolar Disorders, 2020 Nov;22(7):768-770. doi: 10.1111/bdi.12970.
Epub 2020 Jul 12.
 
Kadoya Y, Khan MSR, Oba H, Narumoto J. Factors affecting knowledge about the adult guardianship and civil trust systems: evidence from Japan. J Women Aging. 2020 Feb 11:1-15. doi: 10.1080/08952841.2020.1727711. [Epub ahead of print]

Oba H, Kadoya Y, Matsuoka T, Narumoto J. Cognitive decline reduces household spending among older people. Psychogeriatrics. 2020; 20(1):28-34.
 
Matsumoto Y, Ayani N, Kuwabara K, Ono J, Yamada K, Narumoto J. Transcatheter aortic valve implantation in a patient with schizophrenia who had contraindications for surgical aortic valve replacement: A case  report. Asian J Psychiatr, 2020 Feb 11;50:101965.

Matsumoto Y, Ayani N, Abe Y, Nakayama C, Tsujikawa T, Oda M, Narumoto J. Efficacy of Electroconvulsive Therapy for Treatment-Resistant Depression Caused by Hyperparathyroidism: A Case Report. J ECT, 2020 Jan 6.
[Epub ahead of print]

Matsumoto Y, Ayani N, Narumoto J. Frequency and predictors of perioperative psychiatric symptom worsening among patients with psychiatric disorders. Compr Psychiatry. 2019 Nov; 95;152138
 
Matsuoka T, Ismail Z, Narumoto J. Prevalence of Mild Behavioral Impairment and risk of dementia in a psychiatric outpatient clinic. J Alzheimers Dis 2019; 70(2):505-513.

Matsuoka T, Taniguchi S, Imai A, Fujimoto H, Narumoto J. Preliminary study of the role of general hospital psychiatric ward for patients with
dementia in Japan. Asian J Psychiatr. 2019 Oct 19;47:101837.
[Epub ahead of print]

Watanabe A, Ayani N, Waratani M, Hasegawa T, Ishii M, Matsuoka T, Narumoto J. A Case of Fetal Tachycardia after Electroconvulsive
Therapy: A Possible Effect of Maternal Hypoxia and Uterine
Contractions. Case Rep Psychiatry, 2019 July 4; 2019:3709612.

Matsuoka T, Imai A, Fujimoto H, Kato Y, Shibata K, Nakamura K, Yokota H, Yamada K, Narumoto J. Neural correlates of sleep disturbance in
Alzheimer’s disease: role of the precuneus in sleep disturbance. J Alzheimers Dis 2018,63(3):957-964.

Iida N, Wada Y, Yamashita T, Aoyama M, Hirai K, Narumoto J. Effectiveness of parent training in improving stress-coping capability, anxiety, and depression in mothers raising children with autism spectrum disorder. Neuropsychiatric Disease and Treatment 2018; 14: 3355-3362.

Watanabe A, NakamaeA T, Sakai T Y, Nishida S, Abe Y, Yamada K, Yokota I, & Narumoto J. The detection of white matter alterations in obsessive–
compulsive disorder revealed by TRARActs Constrained by
UnderLying Anatomy (TRACRACULA). Neuropsychiatric Disease and Treatment 2018; 14:1635–1643.

Abe Y, Sakai Y, Nishida S, Nakamae T, Yamada K, Fukui K, & Narumoto J.  Frequency specific analysis revealed the imbalanced functional
networks in obsessive-compulsive disorder. European Neuropsychopharmacology 2018; 28: 768–769

Matsuoka T, Kato Y, Imai A, Fujimoto H, Shibata K, Nakamura K, Yamada K, & Narumoto J. Differences in the neural correlates of frontal lobe tests. Psychogeriatrics 2018; 18: 42-48.

Oba H, Matsuoka T, Imai A, Fujimoto H, Kato Y, Shibata K, Nakamura K, & Narumoto J. Interaction between memory impairment and depressive symptoms can exacerbate anosognosia: a comparison of Alzheimer’s disease with mild cognitive impairment. Aging & Mental Health,
2018; 23(5): 595-601.

Matsuoka T, Fujimoto H, Kato Y, Shibata K, Nakamura K, Yokota H, Yamada K, & Narumoto J. Reduced pineal volume in Alzheimer Disease: A retrospective cross-sectional MR imaging study. Radiology 2017;
286: 239-248,.

Yoshii T, Oishi N, Ikoma K, Nishimura I, Sakai Y, Matsuda K, Yamada S, Tanaka M, Kawata M,  Narumoto J & Fukui K. Brain atrophy in the
visual cortex and thalamus induced by severe stress in animal
model. Scientific Reports 2017; 7: 12731.

Radhakrishnan R, Wasser T, Picon F, Puspanathan P, Pinto da Costa M, Nakamae T, & Elkholy H. Editorial training models for early-career psychiatrists. Lancet Psychiatry 2017; 4(7): 515-516.

Fujimoto H, Matsuoka T, Kato Y, Shibata K, Nakamura K, Yamada K, & Narumoto J. Brain regions associated with anosognosia for memory disturbance in Alzheimer’s disease: a magnetic resonance imaging
study. Neuropsychiatric Disease and Treatment 2017; 13:
1753-1759.

Minamisawa A, Narumoto J, Yokota I, Fukui K. Evaluation of factors associated with psychiatric patient dropout at a university
outpatient clinic in Japan. Patient Preference and Adherence 2016;
10: 1903-1911.

Ayani N, Sakuma M, Morimoto T, Kikuchi T, Watanabe K, Narumoto J,
Fukui K. The epidemiology of adverse drug events and medication
errors among psychiatric inpatients in Japan: the JADE study. BMC Psychiatry 2016; 16: 303, 1-8

Murota M, Iwawaki Y, Uebaba K, Yamamoto Y, Takishita Y, Harada K,
Shibata A, Narumoto J, Fukui K. Physical and Psychological Effects
of Head Treatment in the Supine Position Using Specialized Ayurveda-
Based Techniquea. Journal of Alternative and Complementary
Medicine 2016; 22(7): 526-532.

Matsuoka T, Fujimoto H, Kato Y, Fukui K, Narumoto J. Late-onset psychosis in older outpatients: a retrospective chart review. International Psychogeriatrics 2015; 27(4): 694-696.

Abe Y, Sakai Y, Nishida S, Nakamae T, Yamada K, Fukui K, Narumoto J. Hyper-influence of the orbitofrontal cortex over the ventral striatum
in obsessive-compulsive disorder. European Neuropsychopharmacology 2015; 25: 1898-1905.

Tominaga T, Choi H, Nagoshi Y, Wada Y, Fukui K. Relationship between alexithymia and coping strategies in patients with somatoform
disorder. Neuropsychiatric Disease and Treatment 2014; 10: 55-62.

Nakamae T, Sakai Y, Abe Y, Nishida S, Fukui K, Yamada K, Kubota M,
Denys D, Narumoto J. Altered fronto-striatal fiber topography and connectivity in obsessive-compulsive disorder. PLoS One 2014;
9(11): e112075.

Nakamura M, Hayakawa T, Okamura A, Kohigashi M, Fukui K, Narumoto J. Defensive function of persecutory delusion and discrepancy between
explicit and implicit self-esteem in schizophrenia: study using the
Brief Implicit Association Test. Neuropsychiatric Disease and
Treatment 2014; 11(22): 33-40.

Hatano Y, Yamada M, Nakagawa K, Nanri H, Kawase M, Fukui K. Using drawing tests to explore the multidimensional psychological aspects of children with cancer. Japanese Journal of Clinical Oncology 2014;
44(10): 1009-1012.

Matsuoka T,  Kato Y, Taniguchi S, Ogawa M, Fujimoto H, Okamura A, Shibata K, Nakamura K, Uchida H, Nakaaki S, Koumi H, Mimura M, Fukui K, Narumoto J. Japanese versions of the Executive Interview (J-EXIT25)
and the Executive Clock Drawing Task (J-CLOX) for older people. International Psycogeriatrics 2014; 26(8): 1387-1397.

Nagahara Y, Nakamae T,  Nishizawa S, Mizuhara Y, Moritoki Y, Wada Y,
Sakai Y, Yamashita T, Narumoto J, Miyata J, Yamada K, Fukui K. 
A Tract-Based Spatial Statistics Study in Anorexia Nervosa:
Abnormality in the Fornix and the Cerebellum. Progress in Neuro-
Psychopharmacology & Biological Psychiatry 2014; 51(3):72-77.
 
問い合わせ先 TEL:075-251-5612
FAX:075-251-5839
e-mail:psyche@koto.kpu-m.ac.jp
教室独自のHP https://kpum-psyche.com/
 

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