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病態分子薬理学/薬理学教室

 薬理学教室HP http://www.f.kpu-m.ac.jp/k/pharmaco/index.html

大学院科目名 病態分子薬理学
医学部教室名 薬理学教室
スタッフ
教授  矢部 千尋
 
 
講師(研究准教授)岩田 和実
講師       衣斐 督和
助教(学内講師) 松本 みさき
助教       浅岡 希美
研究内容 酸化ストレスが関わる多様な疾患の分子標的治療をめざして
生体内で酸化ストレス増大をもたらすNADPHオキシダーゼの遺伝子組換えマウスを用いて諸臓器の病態の分子機構を解析している。メタボリックシンドロームの疾患モデルとして非アルコール性肝炎と糖尿病、神経系では痛みや記憶、気分障害モデルを用いて幅広い視点からアプローチを行い、本酵素を標的とする薬物治療戦略への応用を目指している。
研究業績
Wen X, Iwata K, Ikuta K, Zhang X, Zhu K, Ibi M, Matsumoto M, Asaoka N, Liu J, Katsuyama M, Yabe-Nishimura C. NOX1/NADPH oxidase regulates the expression of multidrug resistance-associatedprotein 1 and maintains intracellular glutathione levels. FEBS J. 286(4):678-687. 2019
 
Katsuyama M, Ibi M, Iwata K, Matsumoto M, Yabe-Nishimura C. Clioquinol increases the expression of interleukin-8 by down-regulating GATA-2 and GATA-3. Neurotoxicology. 67:296-304. 2018.
 
Iwata K, Matsuno K, Murata A, Zhu K, Fukui H, Ikuta K, Katsuyama M, Ibi M, Matsumoto M, Ohigashi M, Wen X, Zhang J, Cui W, Yabe-Nishimura C. Up-regulation of NOX1/NADPH oxidase following drug-induced myocardial injury promotes cardiac dysfunction and fibrosis. Free Radic Biol Med.120:277-288. 2018.
 
Matsumoto M, Zhang J, Zhang X, Liu J, Jiang JX, Yamaguchi K, Taruno A, Katsuyama M, Iwata K, Ibi M, Cui W, Matsuno K, Marunaka Y, Itoh Y, Torok NJ, Yabe-Nishimura C. The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease. Free Radic Biol Med. 115:412-420. 2018.
 
Ibi M, Liu J, Arakawa N, Kitaoka S, Kawaji A, Matsuda KI, Iwata K, Matsumoto M, Katsuyama M, Zhu K, Teramukai S, Furuyashiki T, Yabe-Nishimura C. Depressive-Like Behaviors Are Regulated by NOX1/NADPH Oxidase by Redox Modification of NMDA Receptor 1. J Neurosci. 12;37(15):4200-4212. 2017.
 
Bettaieb A, Jiang JX, Sasaki Y, Chao TI, Kiss Z, Chen X, Tian J, Katsuyama M, Yabe-Nishimura C, Xi Y, Szyndralewiez C, Schröder K, Shah A, Brandes RP, Haj FG, Török NJ. Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice. Gastroenterology. 149(2):468-80. 2015

Kojima A, Matsumoto A, Nishida H, Reien Y, Iwata K, Shirayama T, Yabe-Nishimura C, Nakaya H. A protective role of Nox1/NADPH oxidase in a mouse model with hypoxia-induced bradycardia. J Pharmacol Sci. 127(3):370-6. 2015
 
Katsuyama M, Ibi M, Matsumoto M, Iwata K, Ohshima Y, Yabe-Nishimura C. Clioquinol increases the expression of VGF, a neuropeptide precursor, through induction of c-Fos expression. J Pharmacol Sci. 124(4):427-32. 2014
 
Matsumoto M, Katsuyama M, Iwata K, Ibi M, Zhang J, Zhu K, Nauseef WM, Yabe-Nishimura C. Characterization of N-glycosylation sites on the extracellular domain of NOX1/NADPH oxidase. Free Radic Biol Med. 68:196-204, 2014.

Iwata K, Ikami K, Matsuno K, Yamashita T, Shiba D, Ibi M, Matsumoto M, Katsuyama M, Cui W, Zhang J, Zhu K, Takei N, Kokai Y, Ohneda O, Yokoyama T, Yabe-Nishimura C. Deficiency of NOX1/NADPH oxidase leads to pulmonary vascular remodeling. Arterioscler Thromb Vasc Biol., 34:110-9, 2014.

Morimoto H, Iwata K, Ogonuki N, Inoue K, Atsuo O, Kanatsu-Shinohara M, Morimoto T, Yabe-Nishimura C, Shinohara T. ROS are required for mouse spermatogonial stem cell self-renewal. Cell Stem Cell. 12: 774-86, 2013.

Matsuno K, Iwata K, Matsumoto M, Katsuyama M, Cui W, Murata A, Nakamura H, Ibi M, Ikami K, Zhang J, Matoba S, Jin D, Takai S, Matsubara H, Matsuda N, Yabe-Nishimura C. NOX1/NADPH oxidase is involved in endotoxin-induced cardiomyocyte apoptosis.Free Radic Biol Med., 53: 1718-28, 2012.

Ibi M, Matsuno K, Matsumoto M, Sasaki M, Nakagawa T, Katsuyama M, Iwata K, Zhang J, Kaneko S, Yabe-Nishimura C. Involvement of NOX1/NADPH oxidase in morphine-induced analgesia and tolerance. J Neurosci. 31:18094-103, 2011.

Cui W, Matsuno K, Iwata K, Ibi M, Matsumoto M, Zhang J, Zhu K, Katsuyama M, Torok NJ, Yabe-Nishimura C. NADPH oxidase NOX1 promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation. Hepatology, 54:949-58, 2011.

Ibi M, Matsuno K, Shiba D, Katsuyama M, Iwata K, Kakehi T, Nakagawa T, Sango K, Shirai Y, Yokoyama T, Kaneko S, Saito N, Yabe-Nishimura C. Reactive oxygen species derived from NOX1/NADPH oxidase enhance inflammatory pain. J Neurosci. 28:9486-94, 2008.
 
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教室独自のHP http://www.f.kpu-m.ac.jp/k/pharmaco/index.html

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