| 大学院科目名 | 分子病態病理学 |
| 医学部教室名 | 病理学教室（分子病態病理学部門） （附属脳・血管系老化研究センター病態病理学部門） |
| スタッフ |
教授 宮川 文
講師 藤本 崇宏
助教 矢追 毅
助教 丹藤 創
特任教授 伊東 恭子
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| 研究内容 |
京都府立医科大学大学院医学研究科分子病態病理学では、脳神経系の発生に関わる病態解明、自己免疫疾患、臓器移植後合併症等の慢性炎症疾患を中心とした病理学的研究を通して、疾患の病態の本質を解明し、ヒト疾患へのトランスレーショナルな応用を見据え、治療標的分子の同定、治療への展開を目指しています。臨床各科との共同研究も幅広く展開しています。企業との共同研究により様々な光学系・画像処理アルゴリズムを組み合わせた細胞観察装置/手法の開発や病理学分野での人工知能、深層学習を用いた研究・診断法構築に取り組んでいます。また、私たちは病理学教室として、医学部学生への病理学の教育、病理解剖症例の解析やCPC（臨床病理検討会）を担当しています。附属病院病理部では病理診断、臨床とのカンファレンスの一部を担当し、臨床との連携を図ると同時に病理専攻医の育成にも携わっています。
主なる研究プロジェクト
1. 遺伝子改変マウスを用いた神経発生異常の分子病態解明
2. ヒト遺伝性神経・筋疾患における分子病態解明のための基礎的研究（神経型dystrophin:Dp71の分子病態解明に基づく知的障害治療法の深索）
3. 大脳皮質形成障害に関する分子神経生物学的研究
4. ヒト脳形成障害、神経変性疾患ならびに脳の加齢に関する分子病理学的研究
5. 肺腺癌におけるSTASの分子病理学的特性解明：オミクス解析による新規浸潤様式の進展機構解明
6. 早期肺癌におけるSTAS術前診断法の開発と個別化術式選択への応用
7. 間質性肺炎等慢性炎症性疾患のバイオマーカー探索と治療への展開
8. 胆管消失症候群の病態解明
9. アミロイドーシスの臨床病理学的研究
10. 異業種先端技術の医学への応用と、それらを生かした研究手法・研究機器の開発（企業との共同研究）
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| 研究業績 |
1. Fujimoto T, Yaoi T, Tanaka H, Itoh K.
Dystroglycan regulates proper expression, submembranous localization and subsequent phosphorylation of Dp71 through physical interaction. Human Molecular Genetics 2020, 29(19): 3312-3326.
2. Tanaka H, Sawano T, Konishi N, Harada R, Takeuchi C, Shin Y, Sugiura H, Nakatani J, Fujimoto T, Yamagata K.
Serotonin induces Arcadlin in hippocampal neurons. Neuroscience Letters 2020, 721: 134783.
3. Boku S, Watanabe M, Sukeno M, Yaoi T, Hirota K, Iizuka-Ohashi M, Itoh K, Sakai T. Deactivation of glutaminolysis sensitizes pik3ca-mutated colorectal cancer cells to aspirin-induced growth inhibition. Cancers 2020, 12(5)1097.
4. Tando S, Sakai K, Takayama S, Fukunaga K, Higashi M, Fumino S, Aoi S, Furukawa T, Tajiri T, Ogi H, Itoh K.
Maldevelopment of intrapulmonary bronchial cartilage in congenital diaphragmatic hernia. Pediatric Pulmonology 2020, 55(7): 1771-1780.
5. Tando S, Kasai T, Mizuta I, Takahashi H, Yaoi T, Saito K, Hojo T, Mizuno T, Hasegawa M, Itoh K.
An autopsy case of corticobasal syndrome due to asymmetric degeneration of the motor cortex and substantia nigra with TDP-43 proteinopathy, associated with Alzheimer's disease pathology. Neuropathology 2021, 41(3): 214-225.
6. Fujimoto T, Yaoi T, Nakano K, Arai T, Okamura T, Itoh K.
Generation of dystrophin short product-specific tag-insertion mouse: distinct Dp71 glycoprotein complexes at inhibitory postsynapse and glia limitans. Cellular and Molecular Life Sciences 2022, 79: 2-109.
7. Kiso-Farnè K, Yaoi T, Fujimoto T, Itoh K.
Low Doses of Bisphenol A Disrupt Neuronal Differentiation of Human Neuronal Stem/Progenitor Cells. Acta Histochemica et Cytochemica 2022, 55(6): 93-202.
8. Mori M, Tando S, Ogi H, Tonosaki M, Yaoi T, Fujimori A, Itoh K.
Loss of abnormal spindle-like, microcephaly-associated (Aspm) disrupts female folliculogenesis in mice during maturation and aging. Reproductive Biology 2022, 22(3): 100673.
9. Taura Y, Tozawa T, Fujimoto T, Ichise E, Chiyonobu T, Itoh K, Iehara T.
Myosin Va, a Novel Interaction Partner of STXBP1, Is Required to Transport Syntaxin1A to the Plasma Membrane. Neuroscience 2023, 524: 256-268.
10. Fujimoto T, Stam K, Yaoi T, Nakano K, Arai T, Okamura T, Itoh K.
Dystrophin Short Product, Dp71, Interacts with AQP4 and Kir4.1 Channels in the Mouse Cerebellar Glial Cells in Contrast to Dp427 at Inhibitory Postsynapses in the Purkinje Neurons. Molecular Neurobiology 2023, 60(7): 3664-3677.
11. Takahashi H, Fujimoto T, Yaoi T, Fushiki S, Itoh K.
Leukemia inhibitory factor shortens primary cilia by upregulating C-C motif chemokine 2 in human neural stem/progenitor cells. Genes to Cells 2023, 28(12): 868-880.
12. Nakamura R, Fujii H, Yamada T, Matsui Y, Yaoi T, Honda M, Tanaka N, Miyagawa-Hayashino A, Yoshimura A, Morimoto K, Iwasaku M, Tokuda S, Kim Y.H, Konishi E, Itoh K, Takayama K.
Analysis of Tumor Heterogeneity Through AXL Activation in Primary Resistance to EGFR Tyrosine Kinase Inhibitors. JTO Clinical and Research Reports 2023, 4(6): 100525.
13. Furuya T, Ishihara S, Ogi H, Masuda K, Shibata S, Nakazono C, Okada S, Shimomura M, Tando S, Yaoi T, Maeda Y, Yamagishi M, Kawamoto H, Itoh K, Inoue M.
Characteristic differences in the abundance of tumor-infiltrating lymphocytes and intratumoral developing T cells in thymoma, with special reference to PD-1 expression. Cancer Immunology, Immunotherapy 2023, 2(8): 2585-2596.
14. Tonosaki M, Fujimori A, Yaoi T, Itoh K.
Loss of Aspm causes increased apoptosis of developing neural cells during mouse cerebral corticogenesis. PLoS ONE 2023, 18: e0294893.
15. Fujimoto T, Okamura T, Itoh K.
Extraction method combining saponin and trehalose useful for analyzing fragile intermolecular association. Biochemical and Biophysical Research Communications 2024, 727: 150323.
16. Tando S, Kimura T, Mizuhara R, Yuki N, Yoshioka A, Takahashi H, Yasuda R, Itoh K.
An autopsy case of intravascular large B-cell lymphoma showing a rapid transition to embolic strokes with occlusion of the major cerebral arteries. Neuropathology 2024, 44(2): 135-146.
17. Yoshimura A, Horinaka M, Yaoi T, Ono H, Itoh K, Yamada T, Takayama K, Sakai T. Epithelial-mesenchymal transition status is a remarkable biomarker for the combination treatment with avutometinib and defactinib in KRAS-mutated non-small cell lung cancer. British Journal of Cancer 2024, 131(2): 361-371.
18. Honda K, Tasaki M, Yamano T, Ueda M, Naiki H, Tanaka N, Morinaga Y, Miyagawa-Hayashino A.
High frequency of occult transthyretin and apolipoprotein AI–type amyloid in aortic valves removed by valve replacement for aortic stenosis. Amyloid 2025, 32: 22-28.
19. Miyagawa-Hayashino A, Imura T, Takezawa T, Hirai M, Shibata S, Ogi H, Tsujikawa T, Konishi E.
Activation of S1PR2 on macrophages and the hepatocyte S1PR2/RhoA/ROCK1/MLC2 pathway in vanishing bile duct syndrome. PLoS One 2025, 20:e0317568.
20. Matsuura Y, Onuma K, Coppo R, Uematsu H, Kondo J, Miyagawa-Hayashino A, Takeda-Miyata N, Furuya T, Okada S, Shimomura M, Inoue M, Inoue M.
Dynamic change of polarity is involved in the establishment of metastasis by spread through air spaces. J Pathol 2025,265: 260–273.
21. Onishi A, Miyagawa-Hayashino A, Okamoto H, Fujino T, Tsukamoto T, Mizutani S, Shimura Y, Konishi E, Kuroda J.
Phosphorylation status and prognostic impacts of RSK2, PDPK1, and AKT in malignant lymphoma. Leukemia & Lymphoma 2025, 25:1-12.
22. Machuca-Ostos M, de Martines T, Yoshimura K, Mitsuda J, Saburi S, Kimura A, Morimoto H, Yoshizawa K, Sakurai N, Murakami N, Kitamoto K, Yasuda M, Sugiyama Y, Ogi H, Shibata S, Miyagawa-Hayashino A, Konishi E, Itoh K, Tsujikawa T, Hirano S.
Applications of Multiplex Immunohistochemistry in Evaluating Spatiotemporal Heterogeneity of T Cells. Immuno 2025, 5 :1.
23. Fujimoto T, Mori M, Tonosaki M, Yaoi T, Nakano K, Okamura T, Itoh K. Characterization of Dystrophin Dp71 Expression and Interaction Partners in Embryonic Brain Development: Implications for Duchenne/Becker Muscular Dystrophy. Molecular Neurobiology 2025, 62(5): 6256-6272.
24. Miyamoto Y, Tozawa T, Ichise E, Hasegawa T, Fujimoto T, Itoh K, Morimoto M, Iehara T, Chiyonobu T.
Functional verification and allele-specific silencing of a novel AKT3 variant that causes megalencephaly, polymicrogyria and intractable epilepsy. Journal of Human Genetics 2025, 70(5): 281-285.
25. Katsuyama M, Arakawa N, Yaoi T, Kimura E, Matsumoto M, Iwata K, Umemura A, Yabe-Nishimura C.
Clioquinol induces mitochondrial toxicity in SH-SY5Y neuroblastoma cells by affecting the respiratory chain complex IV and OPA1 dynamin-like GTPase. FEBS Letters 2025, 599(8): 1135-1145.
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FAX：075-251-5769（教授室）、5849（教室）
e-mail：pathol（a）koto.kpu-m.ac.jp
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