皮膚科学/皮膚科学教室

 皮膚科学HP http://kpum-dermatology.jp/

大学院科目名 皮膚科学
医学部教室名 皮膚科学教室
スタッフ
教授  加藤 則人
 
 
准教授     竹中 秀也
講師      益田 浩司
講師              浅井 純
助教(学内講師)峠岡 理沙
助教      小森 敏史
助教      金久 史尚
助教      若林 祐輔
研究内容
  1. アトピー性皮膚炎の病態を解明して新たな治療法の開発に貢献することを目標に、アレルギー性皮膚炎における自然免疫の役割に関する研究、体内時計に関する研究、血小板の役割に関する研究、表皮バリア機能に関する研究、疫学研究など、幅広いテーマで研究を行っている。
  2. 糖尿病性潰瘍などの難治性皮膚潰瘍に対する治療法の開発のため、皮膚創傷治癒において最も重要な因子である血管新生・リンパ管新生に焦点を当て、薬剤の投与、細胞移植や遺伝子導入などの治療による骨髄由来血管内皮前駆細胞を介した血管新生への影響を、その治療効果とともに検討している。 
研究業績
  1. Asai J, Hirakawa S, Sakabe J, Kishida T, Wada M, Nakamura N, Takenaka H, Mazda O, Urano T, Suzuki-Inoue K, Tokura Y, Katoh N.  Platelets Regulate the Migration of Keratinocytes via Podoplanin/CLEC-2 Signaling during Cutaneous Wound Healing in Mice.  Am J Pathol 186(1);101-108, 2016.
  2. Wada M, Horinaka M, Yasuda S, Masuzawa M, Sakai T, Katoh N.  PDK1 is a potential therapeutic target against angiosarcoma cells.  J Dermatol Sci 78(1);44-50, 2015.
  3. Nakamura N, Tamagawa-Mineoka R, Ueta M, Kinoshita S, Katoh N.  Toll-like receptor 3 increases allergic and irritant contact dermatitis.  J Invest Dermatol 135(2); 411-417, 2015.
  4. Hagura A, Asai J, Maruyama K, Takenaka H, Kinoshita S, Katoh N.  The VEGF-C/VEGFR3 signaling pathway contributes to resolving chronic skin inflammation by activating lymphatic vessel function.  J Dermatol Sci 73; 135-141, 2014.
  5. Tamagawa-Mineoka R, Okuzawa Y, Masuda K, Katoh N.  Increased serum levels of interleukin 33 in patients with atopic dermatitis.  J Am Acad Dermatol 70(5); 882-888, 2014.
  6. Daito J, Harada Y, Dai P, Yamaoka Y, Tamagawa-Mineoka R, Katoh N, Takamatsu T.  Nertrophil Phagocytosis of Platelets in the Early Phase of 2,4,6-trinitro-1-chlorobenzene(TNCB)-induced Dermatitis in Mice.  Acta Histochem Cytochem 47(2); 67-74, 2014.
  7. Asai J, Harada Y, Beika M, Takenaka H, Katoh N, Takamatsu T.  Photodynamic diagnosis of metastatic lymph nodes using 5-aminolevulinic acid in mouse squamous cell carcinoma.  J Dermatol Sci 74(2); 171-173, 2014.
  8. Kan S, Konishi E, Arita T, Ikemoto C, Takenaka H, Yanagisawa A, Katoh N, Asai J.  Podoplanin expression in cancer-associated fibroblasts predicts attressive behavior in melanoma.  J Cutan Pathol 41(7); 561-567, 2014.
  9. Asai J, Takenaka H, Ii M, Asahi M, Kishimoto S, Katoh N, Losordo DW.  Topical application of ex vivo expanded endothelial progenitor cells promotes vascularisation and wound healing in diabetic mice.  Int Wound J 10(5); 527-533, 2013.
  10. Sano Y, Masuda K, Tamagawa-Mineoka R, Matsunaka H, Murakami Y, Yamashita R, Morita E, Katoh N.  Thymic stromal lymphopoitin expression is increased in the horny layer of patients with atopic dermatitis.  Clin Exp Immunol 171; 330-337, 2013.
  11. Asai J, Takenaka H, Hirakawa S, Sakabe J, Hagura A, Kishimoto S, Maruyama K, Kajiya K, Kinoshita S, Tokura Y, Katoh N. Topical simvastatin accelerates wound healing in diabetes by enhancing angiogenesis and lymphangiogenesis. Am J Pathol 181; 2217-2224, 2012.
  12. Kotani H, Masuda K, Tamagawa-Mineoka R, Nomiyama T, Soga F, Nin M, Asai J, Kishimoto S, Katoh N. Increased plasma LIGHT levels in patients with atopic dermatitis. Clin Exp Immunol 168; 318-324, 2012.
  13. Nishimura Y, Ii M, Qin G, Hamada H, Asai J, Takenaka H, Sekiguchi H, Renault MA, Jujo K, Katoh N, Kishimoto S, Ito A, Kamide C, Kenny J, Millay M, Misener S, Thorne T, Losordo DW.  CXCR4 Antagonist AMD3100 Accelerates Impaired Wound Healing in Diabetic Mice.  J Invest Dermatol 132; 711-20, 2012.
  14. Tamagawa-Mineoka R, Kishida T, Mazda O, Katoh N.  IL-21 reduces immediate hypersensitivity reactions in mouse skin by suppressing mast cell activation or IgE production.  J Invest Dermatol 131; 1513-20, 2011.
  15. Nakai N, Hartmann G, Kishimoto S, Katoh N.   Dendritic cell vaccination in human melanoma: relationships between clinical effects and vaccine parameters. Pigment Cell Melanoma Res. 23; 607–619, 2010.
  16. Tamagawa-Mineoka R, Katoh N, Kishimoto S. Platelets play important roles in the late phase of the immediate hypersensitivity reaction. J Allergy Clin Immunol 123; 581-587, 2009.
  17. Soga F, Katoh N, Inoue T, Kishimoto S.  Serotnin Activates Human Monocytes and Prevents Apoptosis.  J Invest Dermatol 127; 1947-1955, 2007.
  18. Tamagawa-Mineoka R, Katoh N, Ueda E, Takenaka H, Kita M, Kishimoto S.  The Role of Platelets in Leukocyte Recruitment in Chronic Contact Hypersensitivity Induced by Repeated Elicitation.  Am J Pathol 170(6); 2019-2029, 2007.(免疫・微生物学との共同)
  19. Asai J, Takenaka H, Katoh N, Kishimoto S.  Dibutyryl cAMP influences endothelial progenitor cell recruitment during wound neovascularization.  J Invest Dermatol 126;1159-1167, 2006.
  20. Asai J, Takenaka H, Kusano KF, Ii M, Luedemann C, Curry C, Eaton E, Iwakura A, Tsutsumi Y, Hamada H, Kishimoto S, Thorne T, Kishore R, Losordo DW.  Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling.  Circulation 113(20);2413-2424, 2006.
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