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細胞分子機能病理学/病理学教室(細胞分子機能病理学部門)

細胞分子機能病理学HP http://www.f.kpu-m.ac.jp/k/pcr/

大学院科目名 細胞分子機能病理学
医学部教室名 病理学教室(細胞分子機能病理学部門)
スタッフ
 教授  田中 秀央
 
 
准教授     原田 義規
講師(学内)小形 岳寛
助教    中尾 龍太
助教    中村 明宏
助教    望月 健太郎
研究内容
バイオフォトニクス(最新の光技術とバイオテクノロジーの融合)による、機能分子のイメージングと機能制御技術を用いて、病気の発生メカニズム解明を行っている。独自に開発した様々な先端光学顕微鏡を駆使し、病態における機能的・形態的変化を分子・細胞・組織・臓器レベルで、同時にビジュアルイメージとして捉えることにより、病態の発生機序解明と革新的な組織診断技術の開発を目指す。
 
研究内容
1. 心筋機能分子の可視化による心臓の病態の解明
2. 多光子励起による細胞操作
3. ラマン散乱分光法を用いた心筋バイアビリティーに関する研究
4. 光学的手法を用いた腫瘍の微小環境に関する研究
5. 微小癌やリンパ節転移の検出を目指した分子イメージング
6. プロトポルフィリンによる癌の蛍光検出とヘム生合成調節機序に関する研究
研究業績

1. Systems Network Genomic Analysis Reveals Cardioprotective Effect of MURC/Cavin-4 Deletion Against Ischemia/Reperfusion Injury. J. Am. Heart Assoc. 8, e012047(2019).


2. Fluorescence-based discrimination of breast cancer cells by direct exposure to 5-aminolevulinic acid. Cancer Med. 2019 (Epub ahead of print).


3. Terbium ion as RNA tag for slide-free pathology with deep-ultraviolet excitation fluorescence. Sci. Rep. 9, 10745 (2019).


4. Raman spectroscopic histology using machine learning for nonalcoholic fatty liver disease. FEBS Lett. 2019 (Epub ahead of print).


5. High-resolution Raman microscopic detection of follicular thyroid cancer cells with unsupervised machine learning. J. Phys. Chem. B 123, 4358-4372 (2019).


6. High-throughput cell imaging and classification by narrowband and low-spectralresolution Raman microscopy. J. Phys. Chem. B 123, 2654-2661 (2019).


7. Bioconjugation strategy for cell surface labeling with gold nanostructures
designed for highly localized pH measurement. Nat. Commun. 9, 5278 (2018)


8. Label-free evaluation of myocardial infarct in surgically excised ventricular
myocardium by Raman spectroscopy. Sci. Rep. 8, 14671 (2018).


9. Deep-ultraviolet Raman scattering spectroscopy of monolayer WS2. Sci. Rep. 8,11398 (2018).


10. How to adjust endoscopic findings to histopathological findings of the stomach: a "histopathology-oriented" correspondence method helps to understand endoscopic findings. Gastric Cancer 21, 573-577 (2018).


11. Spatiotemporally non-uniform Ca2+ dynamics of cardiac Purkinje fibers in mouse myocardial infarct. J. Histochem. Cytochem. 65, 655-667 (2017).


12. Efficient fluorescence detection of protoporphyrin IX in metastatic lymph nodes of murine colorectal cancer stained with indigo carmine. Photodiag. Photodyn. Therapy 19, 175-180 (2017).


13. Raman micro-spectroscopy as a viable tool to monitor and estimate the ionic transport in epithelial cells. Sci. Rep. 7, 3395 (2017).


14. Label-free detection of myocardial ischaemia in the perfused rat heart by
spontaneous Raman spectroscopy. Sci. Rep. 7, 42401 (2017).


15. Rapid and accurate peripheral nerve imaging by multipoint Raman spectroscopy. Sci. Rep. 7, 845 (2017).


16. Histopathological characteristics of post-inflamed coronary arteries in Kawasaki disease-like vasculitis of rabbits. Acta Histochem. Cytochem. 49, 29-36 (2016).


17. Recent advances in photodynamic diagnosis of gastric cancer using 5-
aminolevulinic acid. World J. Gastroenterol. 22,1289-1296 (2016).


18. Highly sensitive fluorescence detection of metastatic lymph nodes of gastric cancer with photo-oxidation of protoporphyrin IX. Eur. J. Surg. Oncol. 42, 1236-1246 (2016).


19. Simplified and optimized multispectral imaging for 5-ALA-based  fluorescence diagnosis of malignant lesions. Sci. Rep. 6, 25530 (2016).


20. ラマン散乱分光イメージング法による多色摺木版画の色材分子分布解析法の開発. 情報知識学会誌 26, 1-10 (2016).


21. Deep-UV biological imaging by lanthanide ion molecular protection.
Biomed. Opt. Express 7, 158-170 (2016).


22. How Dose the Ca2+-paradox injury induce contracture in the heart?
- A combined study of the intracelluar Ca2+ dynamics and cell structures in perfused rat hearts - Acta Histochem. Cytochem. 48, 1-8 (2015).


23. Highy efficient direct conversion of human fibroblasts to neuronal cells by
chemical compounds. J. Clin. Biochem. Nutr. 56, 166-170 (2015).


24. Interaction of Cx43 with Hsc70 regulates G1/S transition through CDK inhibitor p27. Sci. Rep. 5,15365 (2015).


25. Ex vivo peripheral nerve detection of rats by spontaneous Raman spectroscopy.Sci. Rep. 5, 17165 (2015).


26. Label-free evaluation of myocardinal infarction and its repair by spontaneous Raman spectroscopy. Anal. Chem. 86, 6903-10 (2014).


27. The involvement of the vasa vasorum in the development of vasculitis in animal model of Kawasaki disease.Pediatr. Rheumatol. 12, 12 (2014).


28. Photoacoustic microscopy using ultrashort pulses with two different pulse
durations. Opt. Express 22, 17063-17072 (2014).


29. Photodynamic diagnosis of metastatic lymph nodes using 5-aminolevulinic acid in mouse squamous cell carcinoma. J. Dermatol. Sci. 74, 171-173 (2014).


30. In vivo detection of rat colorectal cancers by using a dual-wavelength excitation method. Acta Histochem. Cytochem. 47, 247-254 (2014).

 

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