京都府立医科大学：Molecular Cardiology and Vascular Regenerative Medicine

Subject

Molecular Cardiology and Vascular Regenerative Medicine

Staff

Professor

Satoaki Matoba

Associate Professor: Takeshi Shirayama
Lecturer：Keiichi Tamagaki

Assistant Professor: Hiroyuki Yamada，Hirokazu Shiraishi，

Takeshi　Nakamura，Tetsuhiro Yamano
Kan Zen, Tetsuro KusabaYayoi Shiotsu, Atsushi Hoshino,
Naohiko Nakanishi, Kenji Yanishi

Research Contents

Our mission is providing high quality patient care, conducting cutting-edge research, and training cardiologists and nephrologists. We are focusing on translating basic research to clinics.

Examples of our pioneering efforts are:
1) transplantation of autologous bone marrow mononuclear cells in peripheral arterial
disease patients
2) elucidation of molecular mechanisms in developing atherosclerosis, hypertension and
heart failure to identify novel therapeutic targets
3) registry and epidemiologic study of acute coronary syndrome in Kyoto and Shiga
4) mechanism of glomerular damage and peritoneal fibrosis upon peritoneal dialysis
5) clinical studies on atherogenesis in chronic kidney disease

Achievements

Cardiac-Specific Bdh1 Overexpression Ameliorates Oxidative Stress and Cardiac Remodeling in Pressure Overload-Induced Heart Failure. Circ Heart Fail.2017
D-Glutamate is metabolized in heart mitochondria.Sci Rep.2017 Mar 7;7:43911.
MURC deficiency in smooth muscle attenuates pulmonary hypertension. Nat Commun.7:12417.2016
Preserved Nephrogenesis Following Partial Nephrectomy in Early Neonates. Sci Rep.6:26792.2016
Loss of Apoptosis Regulator through modulating IAP expression (ARIA) Protects Blood Vessels from Atherosclerosis. 　J Biol Chem. 290:3784-92,2015.
Maternal high-fat diet exaggerates atherosclerosis in adult offspring by augmenting periaortic adipose tissue-specific proinflammatory response. Arterioscler Thromb Vasc Biol. 35:558-69, 2015
Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β cell function in diabetes. Proc Natl Acad Sci U S A.111:3116-3121, 2014.
MURC/Cavin-4 facilitates recruitment of ERKto caveolae and concentric cardiac hypertrophy induced α1-adrenergic receptors. Proc Natl Acad Sci U S A 111:3811-3816, 2014.
Ecscr regulates insulin sensitivity and predisposition to obesity by modulating endothelial cell functions. Nat Commun. 4:2389, 2013.
Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart. Nat Commun. 4:2308, 2013.

Contact

tel 81-75-251-5511
fax 81-75-251-5514
e-mail sirayama@koto.kpu-m.ac.jp

http://www.f.kpu-m.ac.jp/k/med2/index.html

MURC deficiency in smooth muscle attenuates pulmonary hypertension. Nat Commun.7:12417.2016
Preserved Nephrogenesis Following Partial Nephrectomy in Early Neonates. Sci　Rep.6:26792.2016
MURC deficiency in smooth muscle attenuates pulmonary hypertension. Nat Commun.7:12417.2016
Preserved Nephrogenesis Following Partial Nephrectomy in Early Neonates. Sci　Rep.6:26792.2016

Cardiac-Specific Bdh1 Overexpression Ameliorates Oxidative Stress and Cardiac Remodeling in Pressure Overload-Induced Heart Failure. Circ Heart Fail.2017
D-Glutamate is metabolized in heart mitochondria.Sci Rep.2017 Mar 7;7:43911.
Cardiac-Specific Bdh1 Overexpression Ameliorates Oxidative Stress and Cardiac Remodeling in Pressure Overload-Induced Heart Failure. Circ Heart Fail.2017
D-Glutamate is metabolized in heart mitochondria.Sci Rep.2017 Mar 7;7:43911.