京都府立医科大学：Genomic Medical Sciences

Subject	Genomic Medical Sciences
Staff	Professor : Kei Tashiro Associate Professor : Masakazu Nakano Assistant Professor : Natsue Omi, Yuichi Tokuda, Masami Tanaka
Research Contents
Achivements	Takashima Y, Kawaguchi A, Sato R, Yoshida K, Hayano A, Homma J, Fukai J, Iwadate Y, Kajiwara K, Ishizawa S, Hondoh H, Nakano M, Ogawa S, Tashiro K, Yamanaka R. Differential expression of individual transcript variants of PD-1 and PD-L2 genes on Th-1/Th-2 status is guaranteed for prognosis prediction in PCNSL. *Sci Rep.2019 Jul 9(1):10004. Tsukamoto T, Nakano M, Sato R, Adachi H, Kiyota M, Kawata E, Uoshima N, Yasukawa S, Chinen Y, Mizutani S, Shimura Y, Kobayashi T, Horiike S, Yanagisawa A, Taniwaki M, Tashiro K, Kuroda J. High-risk follicular lymphomas harbour more somatic mutations including those in the AID-motif. Sci Rep.2017 Oct 25;7(1):14039. Aung T, Ikeda Y, Ueno M, Sotozono C, Nakano M, Kinoshita S, Tashiro K, Khor CC, et al. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nat Genet.2017 Jul;49(7):993-1004. Omi N, Tokuda Y, Ikeda Y, Ueno M, Mori K, Sotozono C, Kinoshita S, Nakano M, Tashiro K. Efficient and reliable establishment of lymphoblastoid cell lines by Epstein-Barr virus transformation from a limited amount of peripheral blood. Sci Rep.2017 Mar 8;7:43833. Khor CC, Nakano M, Ikeda Y, Ueno M, Mori K, Kinoshita S, Tashiro K, Aung T, et al. Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nat Genet.2016 May;48(5):556-62. Aung T, Nakano M, Ikeda Y, Ueno M, Mori K, Kinoshita S, Tashiro K, Khor CC, et al. A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome. Nat Genet.2015 Apr;47(4):387-92. Nakano M, Ikeda Y, Tokuda Y, Fuwa M, Ueno M, Imai K, Sato R, Omi N, Adachi H, Kageyama M, Mori K, Kinoshita S, Tashiro K. Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population. Sci Rep.2014 Jun 18;4:5340. Ishida H, Yagi T, Tanaka M, Tokuda Y, Kamoi K, Hongo F, Kawauchi A, Nakano M, Miki T, Tashiro K.Identification of a novel gene by whole human genome tiling array. Gene.2013 Mar 1;516(1):33-8. Nakano M, Ikeda Y, Tokuda Y, Fuwa M, Omi N, Ueno M, Imai K, Adachi H, Kageyama M, Mori K, Kinoshita S, Tashiro K. Common variants in CDKN2B-AS1 associated with optic-nerve vulnerability of glaucoma identified by genome-wide association studies in Japanese. PLoS One. 2012 ;7(3):e33389. Nakano M, Ikeda Y, Taniguchi T, Yagi T, Fuwa M, Omi N, Tokuda Y, Tanaka M, Yoshii K, Kageyama M, Naruse S, Matsuda A, Mori K, Kinoshita S, Tashiro K. Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12838-42. Ikegawa M, Han H, Okamoto A, Matsui R, Tanaka M, Omi N, Miyamae M, Toguchida J, Tashiro K. Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice. Dev Dyn. 2008 Sep;237(9):2506-17. Nakamura T, Lozano PR, Ikeda Y, Iwanaga Y, Hinek A, Minamisawa S, Cheng CF, Kobuke K, Dalton N, Takada Y, Tashiro K, Ross J Jr, Honjo T, Chien KR. Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature. 2002 Jan 10;415(6868):171-5. Tanigaki K, Han H, Yamamoto N, Tashiro K, Ikegawa M, Kuroda K, Suzuki A, Nakano T, Honjo T. Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol. 2002 May;3(5):443-50. Tanigaki, K., Nogaki, F, Takahashi, J, Tashiro, K., Kurooka, H. and Honjo, T. Notch1 and Notch3 Instructively Restrict bFGF-Responsive Multipotent Neural Progenitor Cells to an Astroglial Fate. Neuron.* 2001 Jan; 29: 45-55. Shinkura R, Kitada K, Matsuda F, Tashiro K, Ikuta K, Suzuki M, Kogishi K, Serikawa T, Honjo T. Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase. *Nat Genet. 1999 May;22(1):74-7 Tashiro K, Nakamura T, Honjo T. The signal sequence trap method. Methods Enzymol. 1999 ;303:479-95. Winkler C, Honjo T, Tashiro K, Yabe D, O'Brien SJ, et al. Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. Science. 1998 Jan 16;279(5349):389-93. Tashiro K, Tada H, Heilker R, Shirozu M, Nakano T, Honjo T. Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins. Science*. 1993 Jul 30;261(5121):600-3.
Contact	tel 81-75-251-5346 fax 81-75-251-5347 e-mail tashiro@koto.kpu-m.ac.jp
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