京都府立医科大学：Pediatric Surgery

Subject

Pediatric Surgery

Staff

Professor : Shigeru Ono

Associate Professor : Shigehisa Fumino

Lecturer : Kiyokazu Kim

Assistant Professor : Shohei Takayama,Masafumi Iguchi,Maho Inoue

Research Cotents

Development of a Novel Drug Delivery System for Neuroblastoma Using Mesenchymal Stem Cells
Preclinical Studies of Neuroblastoma Therapy with Novel Molecular Targeted Agents
Mechanistic Analysis of Local Therapy for Neuroblastoma and Metastatic Progression
Development of Regenerative Medicine for Congenital Skeletal Muscle Deficiency
Analysis of Aberrant Immunity in the Extrahepatic Bile Duct of Biliary Atresia and Its Potentiating Factors
Development of Multidisciplinary Therapies for Refractory Lymphatic Malformations

Achievements

Suzuki K, Fumino S, Iguchi M, Takayama S, Kim K, Hirano S, Ono S: Multidisciplinary therapeutic strategy with appropriate timing and modalities for treating cervicofacial lymphatic malformations in children. Pediatr Surg Int, 41:35, 2024.
Takimoto A, Fumino S, Iguchi M, Takayama S, Kim K, Aoi S, Ono S: Comparison of postoperative urinary complications in laparoscopic-assisted anorectoplasty versus posterior sagittal anorectoplasty for anorectal malformation with rectourethral fistula. Pediatr Surg Int, 40: 111, 2024.
Shimamura A, Higashi M, Nagayabu K, Ono S: Stable two- and threedimensional cholangiocyte culture systems from extrahepatic bile ducts of biliary atresia patients: use of structural and functional bile duct epithelium models for in vitro analyses. Cytotechnology, 76: 415–424, 2024.
Nagano S, Fumino S, Kishida T, Wakao J, Hirohata Y, Takayama S, Kim K, Akiyoshi K, Mazda O, Tajiri T, Ono S: Development of a skeletal muscle sheet with direct reprogramming-induced myoblasts on a nanogel-cross-linked porous freeze-dried gel scaffold in a mouse gastroschisis model. Pediat Surg Int, 40:241, 2024.
Mimura K, Fumino S, Yamashi K, Iguchi M, Inoue M, Takayama S, Kim K, Aoi S, Ono S: Systemic inflammation enhances metastatic growth in a syngeneic neuroblastoma mouse model. Pediatr Surg Int, 40: 195, 2024.
Iguchi M, Yagyu S, Kambe K, Higashi M, Fumino S, Kishida T, Iehara T, Mazda O, Tajiri T: Development of anti-GD2 Antibody-producing Mesenchymal Stem Cells as Cellular Immunotherapy. Anticancer Res, 43: 2417-2424, 2023.
Kambe K, Iguchi M, Higashi M, Yagyu, S, Fumino S, Kishida T, Mazda O, Tajiri T: Development of minimally invasive cancer immunotherapy using anti–disialoganglioside GD2 antibody-producing mesenchymal stem cells for neuroblastoma mouse model. Pediatr Surg Int, 39: 43, 2022.
Sengoku Y, Higashi M, Nagayabu K, Takayama S, Fumino S, Aoi S, Furukawa T, Tajiri T: IL13 and periostin in active fbrogenic areas of the extrahepatic bile ducts in biliary atresia patients. Pediatr Surg Int, 38: 1847-1853, 2022.
Togashi T, Tanaka T, Takemoto M, Takeuchi Y, Higashi M, Fumino S, Tajiri T: Anti-relapse effect of trametinib on a local minimal residual disease neuroblastoma mouse model. J Pediatr Surg, 56: 1233-1239, 2021.
Takemoto M, Tanaka T, Tsuji R, Togashi Y, Higashi M, Fumino S, Tajiri T: The synergistic antitumor effect of combination therapy with a MEK inhibitor and YAP inhibitor on pERK-positive neuroblastoma. Biochem Biophys Res Commun, 570: 41-46, 2021.

Contact

TEL：81-75-251-5809

FAX：81-75-251-5828

e-mail：pedsurg@koto.kpu-m.ac.jp

http://pedsurg.kpu-m.ac.jp/index.php