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Pediatric Surgery

 
Subject Pediatric Surgery
Staff
 
Professor : Shigeru Ono
 
Associate Professor : Shigehisa Fumino
Lecturer : Kiyokazu Kim
Assistant Professor : Masafumi Iguchi, Maho Inoue, Kazuya Nagayabu
 
Research Cotents
Major Basic Research Topics
  1. Mesenchymal stem cell–based homing effects and differentiation-inducing therapy for neuroblastoma
  2. Preclinical studies of neuroblastoma treatment using novel molecular-targeted agents
  3. The impact of surgical treatment on metastatic lesions in neuroblastoma
  4. Development of regenerative medicine for congenital skeletal muscle defects
  5. Analysis of the role of macrophages in biliary atresia and their function as therapeutic targets
Major Clinical Research Topics
  1. Clinical efficacy of mTOR inhibitors for lymphangioma
  2. Research on the standardization of treatment for neonatal congenital diaphragmatic hernia
  3. Establishment of a comprehensive treatment strategy for short bowel syndrome
  4. Development of novel minimally invasive surgical treatments
  5. Surgical treatment for pediatric solid tumors
  1. Achievements
  1. Kimura K, Kishida T, Wakao J, et al: Tumor-homingeffect of human mesenchymal stem cells in a TH-MYCN mouse model of neuroblastoma. J Pediatr Surg, 51: 2068-2073, 2016.
  2. Wakao J, Kishida T, Fumino S, et al: Efficient direct conversion of human fibroblasts intomyogenic lineage induced by co-transduction with MYCL and MYOD1. Biochem BiophysRes Commun, 488: 368-373, 2017.
  3. Takeuchi Y, Tanaka T, Higashi M, et al: In vivo effects of short- and long-term MAPK pathway inhibition against neuroblastoma. J Pediatr Surg, 53: 2454-2459, 2018.
  4. Maniwa J, Fumino S, Kimura K, et al: Novel mesenchymal stem celldelivery system as targeted therapy for neuroblastoma using the TH-MYCN mouse model. J Pediatr Surg, 54: 2600-2605, 2019.
  5. Inoue M, Tsuchiya Y, Koike N, et al: Enhanced metastatic growth after local tumor resection in the presence of synchronous metastasis in a mouseallograft model of neuroblastoma. Pediatr Surg Int, 35, 1403–1411, 2019.
  6. Takayama S, Sakai K, Fumino S, et al: An intra-amniotic injection of mesenchymal stem cells promotes lung maturity in a rat congenital diaphragmatic hernia model. Pediatr Surg Int, 35: 1353-1361, 2019.
  7. Togashi T, Tanaka T, Takemoto M, et al: Anti-relapse effect of trametinib on alocal minimal residual disease neuroblastoma mouse model. J Pediatr Surg, 56: 1233-1239, 2021.
  8. Takemoto M, Tanaka T, Tsuji R, et al: The synergistic antitumor effect ofcombination therapy with a MEK inhibitor and YAP inhibitor on pERK-positive neuroblastoma. Biochem Biophys ResCommun, 570: 41-46, 2021.
  9. Kambe K, Iguchi M, Higashi M, et al: Development of minimallyinvasive cancer immunotherapy using anti–disialoganglioside GD2 antibody-producing mesenchymal stem cells forneuroblastoma mouse model. Pediatr Surg Int, 39: 43, 2022.
  10. Sengoku Y, Higashi M, Nagayabu K, et al: IL13 and periostin in active fbrogenic areas of the extrahepatic bile ducts in biliary atresia patients. Pediatr Surg Int, 38: 1847-1853, 2022.
  11. Iguchi M, Yagyu S, Kambe K, et al: Development of anti-GD2 Antibody-producing Mesenchymal Stem Cells as Cellular Immunotherapy. Anticancer Res, 43: 2417-2424, 2023.
  12. Mimura K, Fumino S, Yamashi K, et al: Systemic inflammationenhances metastatic growth in a syngeneic neuroblastoma mouse model. Pediatr Surg Int, 40: 195, 2024.
  13. Shimamura A, Higashi M, Nagayabu K, et al: Stable two- and threedimensional cholangiocyte culture systems from extrahepatic bile ducts of biliary atresia patients: use of structural and functional bile duct epithelium models for in vitro analyses. Cytotechnology, 76: 415–424, 2024.
  14. Nagano S, Fumino S, Kishida T, et al: Development of a skeletal muscle sheet with direct reprogramming-induced myoblasts on a nanogel-cross-linked porous freeze-dried gel scaffold in a mouse gastroschisis model. Pediat Surg Int, 40:241, 2024.
  15. Suzuki K, Fumino S, Iguchi M, et al: Multidisciplinary therapeutic strategy with appropriate timing and modalities for treating cervicofacial lymphatic malformations in children. Pediatr Surg Int, 41:35, 2024.
  16. Tsuji R, Tanaka T, Fumino S, et al: Combined MEK and YAPinhibition in a mouse model of neuroblastoma: A promising approach for minimal residual disease. J Pediatr Surg,2025, in press.
Contact
TEL：81-75-251-5809
FAX：81-75-251-5828
e-mail：pedsurg@koto.kpu-m.ac.jp
HP http://pedsurg.kpu-m.ac.jp/index.php
 

 

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