In our department, research is conducted by four major subgroups; otology, rhinology, laryngology, and head and neck cancer. The current areas of interest are as follows.
 

 

 Otology
Mechanisms of the inner ear homeostasis.

 Mechanisms of the EP (endocochlear potential) generation.
Ultrastructure and molecular components of the stereocilia.
Physiology of the vestibular and oculomotor systems.

 

 

Rhinology
A novel therapeutic approach for allergic rhinitis using cytokines.
Ion transport in the nasal and sinus membrane.
Intercellular signaling in the nasal and sinus membrane via gap junctions.

 

 

Laryngology
Wound healing mechanism and regenerative medicine of the larynx
Central mechanism for control of voice and swallow

 

 

Head and Neck Cancer
Immune micro-environment of head and neck cancer and thyroid cancer
Organ preservation treatment for advanced head and neck cancer
Clinical and basic research for head and neck cancer in elderly
Impact of mycology on head and neck cancer

 

 

 

 

Mukudai S, Matsuda K, Bando H, Takanami K, Nishio T, Sugiyama Y, Hisa Y, Kawata M. Expression of sex steroid hormone receptors in vagal motor neurons innervating the trachea and esophagus in mouse. Acta Histochem Cytochem 2016; 49: 37-46

Kamitani T, Sakaguchi H, Tamura A, Miyashita T, Yamazaki Y, Tokumasu R, Inamoto R, Matsubara A, Mori N, Hisa Y, Tsukita S.
Deletion of tricellulin causes progressive hearing loss associated with degeneration of cochlear hair cells. Sci Rep 2015; 5: 18402

Sugiyama Y, Shiba K, Mukudai S, Umezaki T, Sakaguchi H, Hisa Y. Role of the retrotrapezoid nucleus/parafacial respiratory group in coughing and swallowing in guinea pigs. J Neurophysiol 2015; 114: 1792-805

Lehnen N, Heuser F, Sağlam M, Schulz CM, Wagner KJ, Taki M, Kochs EF, Jahn K, Brandt T, Glasauer S, Schneider E. Opioid-induced nausea involves a vestibular problem preventable by head-rest. PLoS One 2015; 10: e0135263

Mukudai S, Matsuda KI, Nishio T, Sugiyama Y, Bando H, Hirota R, Sakaguchi H, Hisa Y, Kawata M. Differential responses to steroid hormones in fibroblasts from the vocal fold, trachea, and esophagus. Endocrinology 2015; 156: 1000-9

Ohmura G, Tsujikawa T, Yaguchi T, Kawamura N, Mikami S, Sugiyama J, Nakamura K, Kobayashi A, Iwata T, Nakano H, Shimada T, Hisa Y, Kawakami Y. Aberrant Myosin 1b Expression Promotes Cell Migration and Lymph Node Metastasis of HNSCC. Mol Cancer Res 2015; 13: 721-31

Kobayashi M, Nakamura T, Yasuda M, Hata Y, Okura S, Iwamoto M, Nagata M, Fullwood NJ, Koizumi N, Hisa Y, Kinoshita S. Ocular surface reconstruction with a tissue-engineered nasal mucosal epithelial cell sheet for the treatment of severe ocular surface diseases. Stem Cells Transl Med 2015; 4: 99-109