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Orthopaedics / Pediatric Orthopaedics

Subject Orthopaedics / Pediatric Orthopaedics
Professor: Kenji Takahashi
Associate Professors: Toshiharu Shirai, Yuji Arai, Daisaku Tokunaga,
Kazuya Ikoma
Lecturer: Ryo Oda, Masateru  Nagae, Ryu Terauchi, Yoshinobu Oka,
Masahiro Maki, Masashi Ishida, Ryota Takatori
Assistant Professors: Hitoshi Tonomura,Tsuyoshi Goto, Shinji Tsuchida,
Shuji Nakagawa, Naoyuki Horie, Yoshikazu Kida,
Shigeki Hayashi, Tsuyoshi Sukenari, Naoki Okubo
Research Contents
The fieldof orthopaedics covers the treatment of a wide range of patients of all ages with various joint disorders, including disorders of the hip, knee, foot, shoulder, and elbow, spinal disease, hand and peripheral nerve injuries, rheumatoid arthritis; osteoporosis, bone and soft-tissue tumors, fractures; and sports injuries. We engage in both basic and clinical research aiming to elucidate pathological conditions and to develop new methods of diagnosis and treatment for these disorders. Our research is funded not only publicly, by Grants-in-Aid for Scientific Research from the Ministry of Health, Labour and Welfare and by research funds from the Ministry of Education, Culture, Sports, Science and Education, but also privately, through the acquisition of various competitive funding sources. One of the representative research topics of our department is the piezoelectricity of bone, the elucidation of which was an outstanding achievement now engraved into the history of Japanese Orthopaedic Association. Another of our research theme is idiopathic osteonecrosis of the femoral head (ION): our department is a global leader for the prevention of steroid-induced ION (development of preventive method such as gene analysis and electromagnetic field stimulation, so on). Basic research is also being conducted in several other areas, including development of the new treatment method for osteoarthritis targeting HIF-1 alpha, comprehensive study concerning fracture healing and circadian rhythm, investigation of the reaction mechanism of chondroblasts under stress of physiological hypoxic environment, treatment of joint disorders using small interfering RNA, the promotion of regeneration of peripheral nerves and skeletal muscle, intervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres, and the anticancer or antimetastatic effect of bisphosphonate and sulforaphane, which target cancer-related genes and may help treat malignant bone and soft-tissue tumors. We are also conducting clinical research in several areas, namely, radial imaging as a method of evaluating the condition of the acetabular labrum in hip dysplasia, minimally invasive microscopic or microendoscopic muscle-preserving interlaminar decompression for lumbar spinal canal stenosis, 10 year epidemiological study of deformity in the rheumatoid hand, visualization of pain in lumber spinal canal stenosis using functional MRI of the brain, establishment of a new image analysis method for foot and ankle deformity. Through these studies, we aim to realize original research with a global impact.
Major achievements
  • Ikuta F, Takahashi K, Hashimoto S, Mochizuki Y, Yuzawa Y, Inanami H, Takai S. Effect of physical therapy on early knee osteoarthritis with medial meniscal posterior tear assessed by MRI T2 mapping and 3D-to-2D registration technique: A prospective intervention study. Mod Rheumatol 6: 1-10, 2019. (IF=1.973)
  • Shindo Y, Kato K, Ikuta F, Takahashi K. Validation of Noninvasive Ultrasound Temperature Measurement System Through Experiments Using Resonant Cavity Applicator. Conf Proc IEEE Eng Med Biol Soc Jul: 2521-2524, 2019.
  • Takahashi K, Nakamura H, Watanabe A, Majima T, Koiwa M, Kamada T, Takai S. Polymorphism in organic anion-transporting polypeptide gene related to methotrexate response in rheumatoid arthritis treatment. J Nippon Med Sch, in press. (IF=0.484)
  • Masaki T, Takahashi K, Hashimoto S, Ikuta F, Watanabe A, Kiuchi S, Okuaki T, Mochizuki Y, Takai S. Volume change in infrapatellar fat pad is associated not with obesity but with cartilage degeneration. J Orthop Res 37: 593-600, 2019. (IF=3.414)
  • Mochizuki Y, Chiba T, Kataoka K, Yamashita S, Sato T, Kato T, Takahashi K, Miyamoto T, Kitazawa M, Hatta T, Natsume T, Takai S, Asahara H. Combinatorial CRISPR/Cas9 approach to elucidate a far-upstream enhancer complex for tissuespecific Sox9 expression. Dev Cell 46: 794-806, 2018. (IF=9.616)
  • Takahashi K, Nakamura H, Ozawa H, Hashimoto S, Iijima N, Higo S, Watanabe H, Mochizuki Y, Takai S. Effectiveness of radiofrequency hyperthermia for treating cartilage in guinea pigs with primary osteoarthritis. Cartilage 9: 71-79,2018. (IF=2.621)
  • Takahashi K, Hashimoto S, Kiuchi S, Watanabe A, Nakamura H, Ikuta F, Okuaki T, Kataoka T, Majima T, Takai S. Bone morphological factors influencing cartilage degeneration in the knee. Mod Rheumatol 28: 351-357, 2018. (IF=1.955)
  • Shindo Y, Takahashi K, Ikuta F, Iseki Y, Kato K. Improved deep thermal rehabilitation system with temperature measurement function using ultrasaound images. Thermal Medicine 33: 91-101,2017.
  • Takahashi K, Hashimoto S, Kurosaki H, Kato K, Majima T, Shindo Y, Watanabe H, Mochizuki Y, Takai S. A pilot study comparing the efficacy of radiofrequency and microwave diathermy in knee osteoarthritis. J Phys Ther Sci 28: 525-529, 2016. (IF=0.392)
TEL 81-75-251-5549
FAX 81-75-251-5841
E-mail orthoped@koto.kpu-m.ac.jp
HP  http://www.f.kpu-m.ac.jp/k/orthoped/

602-8566 Kyoto-shi, Kamigyo-ku Kajii-cho,
Kawaramachi-Hirokoji, JAPAN