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Department of Immunology

Subject Department of Immunology
Professor Osam Mazda
Research professor: Masakazu Kita
Associate professor: Tsunao Kishida
Assistant professor: Eriko Ohgitani
Assistant professor: Masaharu Shin-Ya
Assistant professor: Eri Watanabe
Research Contents
We are promoting basic and applied research projects on the immune system and related high-order biological systems using a variety of advanced technologies. They include:
  •  Analysis and regulation of stem cells, cell differentiation and reprogramming
  •  Analysis and regulation of cytokine functions and signal transduction
  •  Analysis and regulation of anti-virus immune responses
  •  Analysis and regulation of immune responses in allergic diseases
  •  Analysis and regulation of immune responses against malignancies



Yamamoto K, Sato Y, Honjo K, Ichioka H, Oseko F, Sowa Y, Yamamoto T, Kanamura N, Kishida T, & Mazda O.
Generation of directly converted human osteoblasts that are free of exogenous gene and xenogenic protein
J Cell Biochem, (in press)
Nishioka K, Kishida T, Masui S, & Mazda O.
De novo CpG methylation on an artificial chromosome-like vector maintained for a long-term in mammalian cells.
Biotechnol Lett. 38 (4): 731-740, 2016.
Kishida T, Ejima A, Yamamoto K, Tanaka S, Yamamoto T, & Mazda O.
Reprogrammed Functional Brown Adipocytes Ameliorate Insulin Resistance and Dyslipidemia in Diet-Induced Obesity and Type 2 Diabetes.
Stem Cell Reports. 5 (4): 569-581, 2015.
Yamamoto K, Kishida T, Sato Y, Nishioka K, Ejima A, Fujiwara H, Kubo T, Yamamoto T, Kanamura N, & Mazda O.
Direct conversion of human fibroblasts into functional osteoblasts by defined factors.
Proc Natl Acad Sci USA. 112(19): 6152-6157, 2015.
Fujii H, Shin-Ya M, Takeda S, Hashimoto Y, Mukai S, Sawada S, Adachi T, Akiyoshi K, Miki T, & Mazda O.
Cycloamylose-nanogel drug delivery system-mediated intratumor silencing of the vascular endothelial growth factor regulates neovascularization in tumor microenvironment
Cancer Sci. 105(12):1616-1625, 2014.
e-mail:mazda at koto.kpu-m.ac.jp

602-8566 Kyoto-shi, Kamigyo-ku Kajii-cho,
Kawaramachi-Hirokoji, JAPAN