| Subject | Molecular Pharmacology | ||
| Staff |
Research Professor: Kazumi Iwata Assistant Professor: Misaki Matsumoto
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| Research Contents | under construction; in preparation | ||
| Achievements |
Katsuyama M, Kimura E, Ibi M, Iwata K, Matsumoto M, Asaoka N, Yabe-Nishimura C.
Clioquinol inhibits dopamine-β-hydroxylase secretion and noradrenaline synthesis by affecting the redox status of ATOX1 and copper transport in human neuroblastoma SH-SY5Y cells. Arch Toxicol. In press.
Liu J, Iwata K, Zhu K, Matsumoto M, Matsumoto K, Asaoka N, Zhang X, Ibi M, Katsuyama M, Tsutsui M, Kato S, Yabe-Nishimura C. NOX1/NADPH oxidase in bone marrow-derived cells modulates intestinal barrier function. Free Radic Biol Med. 147:90-101. 2020.
Yamamoto K, Yamada H, Wakana N, Kikai M, Terada K, Wada N, Motoyama S, Saburi M, Sugimoto T, Kami D, Ogata T, Ibi M, Yabe-Nishimura C, Matoba S. Augmented neutrophil extracellular traps formation promotes atherosclerosis development in socially defeated apoE -/- mice. Biochem Biophys Res Commun. 500(2):490-496. 2020.
Wen X, Iwata K, Ikuta K, Zhang X, Zhu K, Ibi M, Matsumoto M, Asaoka N, Liu J, Katsuyama M, Yabe-Nishimura C. NOX1/NADPH oxidase regulates the expression of multidrug resistance-associatedprotein 1 and maintains intracellular glutathione levels. FEBS J. 286(4):678-687. 2019
Katsuyama M, Ibi M, Iwata K, Matsumoto M, Yabe-Nishimura C. Clioquinol increases the expression of interleukin-8 by down-regulating GATA-2 and GATA-3. Neurotoxicology. 67:296-304. 2018.
Iwata K, Matsuno K, Murata A, Zhu K, Fukui H, Ikuta K, Katsuyama M, Ibi M, Matsumoto M, Ohigashi M, Wen X, Zhang J, Cui W, Yabe-Nishimura C. Up-regulation of NOX1/NADPH oxidase following drug-induced myocardial injury promotes cardiac dysfunction and fibrosis. Free Radic Biol Med.120:277-288. 2018.
Matsumoto M, Zhang J, Zhang X, Liu J, Jiang JX, Yamaguchi K, Taruno A, Katsuyama M, Iwata K, Ibi M, Cui W, Matsuno K, Marunaka Y, Itoh Y, Torok NJ, Yabe-Nishimura C. The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease. Free Radic Biol Med. 115:412-420. 2018.
Ibi M, Liu J, Arakawa N, Kitaoka S, Kawaji A, Matsuda KI, Iwata K, Matsumoto M, Katsuyama M, Zhu K, Teramukai S, Furuyashiki T, Yabe-Nishimura C. Depressive-Like Behaviors Are Regulated by NOX1/NADPH Oxidase by Redox Modification of NMDA Receptor 1. J Neurosci. 12;37(15):4200-4212. 2017.
Bettaieb A, Jiang JX, Sasaki Y, Chao TI, Kiss Z, Chen X, Tian J, Katsuyama M, Yabe-Nishimura C, Xi Y, Szyndralewiez C, Schröder K, Shah A, Brandes RP, Haj FG, Török NJ. Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice. Gastroenterology. 149(2):468-80. 2015
Kojima A, Matsumoto A, Nishida H, Reien Y, Iwata K, Shirayama T, Yabe-Nishimura C, Nakaya H. A protective role of Nox1/NADPH oxidase in a mouse model with hypoxia-induced bradycardia. J Pharmacol Sci. 127(3):370-6. 2015 Katsuyama M, Ibi M, Matsumoto M, Iwata K, Ohshima Y, Yabe-Nishimura C. Clioquinol increases the expression of VGF, a neuropeptide precursor, through induction of c-Fos expression. J Pharmacol Sci. 124(4):427-32. 2014
Iwata K, Ikami K, Matsuno K, Yamashita T, Shiba D, Ibi M, Matsumoto M, Katsuyama M, Cui W, Zhang J, Zhu K, Takei N, Kokai Y, Ohneda O, Yokoyama T, Yabe-Nishimura C. Deficiency of NOX1/NADPH oxidase leads to pulmonary vascular remodeling. Arterioscler Thromb Vasc Biol., 34:110-9, 2014. Morimoto H, Iwata K, Ogonuki N, Inoue K, Atsuo O, Kanatsu-Shinohara M, Morimoto T, Yabe-Nishimura C, Shinohara T. ROS are required for mouse spermatogonial stem cell self-renewal. Cell Stem Cell. 12: 774-86, 2013. Matsuno K, Iwata K, Matsumoto M, Katsuyama M, Cui W, Murata A, Nakamura H, Ibi M, Ikami K, Zhang J, Matoba S, Jin D, Takai S, Matsubara H, Matsuda N, Yabe-Nishimura C. NOX1/NADPH oxidase is involved in endotoxin-induced cardiomyocyte apoptosis.Free Radic Biol Med., 53: 1718-28, 2012. |
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| Contact |
Tel +81-75-251-5332
Fax +81-75-251-5348
e-mail yakuri@koto.kpu-m.ac.jp
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