京都府立医科大学：Dermatology

Subject

Dermatology

Staff

Professor: Norito Katoh

Associate Professor: Koji Masuda

Lecturer: Jun Asai, Risa Mineoka

Assistant　Professor: Satoshi Komori, Makoto Wada, Fuminao Kanehisa

Research Contents

Atopic Dermatitis

１．Atopic Dermatitis

To elucidate the mechanisms of atopic dermatitis and develop the novel method of treatment, we study the broad themes in allergic dermatitis: the role of innate immunity, the biological clock, the role of platelets, the skin barrier function, and the epidemiologic study.

２．Diabetic Ulcer

For treating the refractory skin ulcer such as diabetic ulcer, we focus on the angiogenesis and lymphangiogenesis which are major factors in wound healing. We investigate the influence and therapeutic effect on angiogenesis via endothelial progenitor cells from bone marrow mononuclear cells, by drug administration, cell transplantation and gene transfer.

Achievements

Asai J, Hirakawa S, Sakabe J, Kishida T, Wada M, Nakamura N, Takenaka H, Mazda O, Urano T, Suzuki-Inoue K, Tokura Y, Katoh N. Platelets Regulate the Migration of Keratinocytes via Podoplanin/CLEC-2 Signaling during Cutaneous Wound Healing in Mice. Am J Pathol 186(1);101-108, 2016.
Wada M, Horinaka M, Yasuda S, Masuzawa M, Sakai T, Katoh N. PDK1 is a potential therapeutic target against angiosarcoma cells. J Dermatol Sci 78(1);44-50, 2015.
Nakamura N, Tamagawa-Mineoka R, Ueta M, Kinoshita S, Katoh N. Toll-like receptor 3 increases allergic and irritant contact dermatitis. J Invest Dermatol 135(2); 411-417, 2015.
Hagura A, Asai J, Maruyama K, Takenaka H, Kinoshita S, Katoh N. The VEGF-C/VEGFR3 signaling pathway contributes to resolving chronic skin inflammation by activating lymphatic vessel function. J Dermatol Sci 73; 135-141, 2014.
Tamagawa-Mineoka R, Okuzawa Y, Masuda K, Katoh N. Increased serum levels of interleukin 33 in patients with atopic dermatitis. J Am Acad Dermatol 70(5); 882-888, 2014.
Daito J, Harada Y, Dai P, Yamaoka Y, Tamagawa-Mineoka R, Katoh N, Takamatsu T. Nertrophil Phagocytosis of Platelets in the Early Phase of 2,4,6-trinitro-1-chlorobenzene(TNCB)-induced Dermatitis in Mice. Acta Histochem Cytochem 47(2); 67-74, 2014.
Asai J, Harada Y, Beika M, Takenaka H, Katoh N, Takamatsu T. Photodynamic diagnosis of metastatic lymph nodes using 5-aminolevulinic acid in mouse squamous cell carcinoma. J Dermatol Sci 74(2); 171-173, 2014.
Kan S, Konishi E, Arita T, Ikemoto C, Takenaka H, Yanagisawa A, Katoh N, Asai J. Podoplanin expression in cancer-associated fibroblasts predicts attressive behavior in melanoma. J Cutan Pathol 41(7); 561-567, 2014.
Asai J, Takenaka H, Ii M, Asahi M, Kishimoto S, Katoh N, Losordo DW. Topical application of ex vivo expanded endothelial progenitor cells promotes vascularisation and wound healing in diabetic mice. Int Wound J 10(5); 527-533, 2013.
Sano Y, Masuda K, Tamagawa-Mineoka R, Matsunaka H, Murakami Y, Yamashita R, Morita E, Katoh N. Thymic stromal lymphopoitin expression is increased in the horny layer of patients with atopic dermatitis. Clin Exp Immunol 171; 330-337, 2013.
Asai J, Takenaka H, Hirakawa S, Sakabe J, Hagura A, Kishimoto S, Maruyama K, Kajiya K, Kinoshita S, Tokura Y, Katoh N. Topical simvastatin accelerates wound healing in diabetes by enhancing angiogenesis and lymphangiogenesis. Am J Pathol 181; 2217-2224, 2012.
Kotani H, Masuda K, Tamagawa-Mineoka R, Nomiyama T, Soga F, Nin M, Asai J, Kishimoto S, Katoh N.　Increased plasma LIGHT levels in patients with atopic dermatitis.　Clin Exp Immunol 168; 318-324, 2012.
Nishimura Y, Ii M, Qin G, Hamada H, Asai J, Takenaka H, Sekiguchi H, Renault MA, Jujo K, Katoh N, Kishimoto S, Ito A, Kamide C, Kenny J, Millay M, Misener S, Thorne T, Losordo DW. CXCR4 Antagonist AMD3100 Accelerates Impaired Wound Healing in Diabetic Mice. J Invest Dermatol 132; 711-20, 2012.
Tamagawa-Mineoka R, Kishida T, Mazda O, Katoh N. IL-21 reduces immediate hypersensitivity reactions in mouse skin by suppressing mast cell activation or IgE production. J Invest Dermatol 131; 1513-20, 2011.
Nakai N, Hartmann G, Kishimoto S, Katoh N. Dendritic cell vaccination in human melanoma: relationships between clinical effects and vaccine parameters. Pigment Cell Melanoma Res. 23; 607–619, 2010.
Tamagawa-Mineoka R, Katoh N, Kishimoto S. Platelets play important roles in the late phase of the immediate hypersensitivity reaction. J Allergy Clin Immunol 123; 581-587, 2009.
Soga F, Katoh N, Inoue T, Kishimoto S. Serotnin Activates Human Monocytes and Prevents Apoptosis. J Invest Dermatol 127; 1947-1955, 2007.
Tamagawa-Mineoka R, Katoh N, Ueda E, Takenaka H, Kita M, Kishimoto S. The Role of Platelets in Leukocyte Recruitment in Chronic Contact Hypersensitivity Induced by Repeated Elicitation. Am J Pathol 170(6); 2019-2029, 2007.（免疫・微生物学との共同）
Asai J, Takenaka H, Katoh N, Kishimoto S. Dibutyryl cAMP influences endothelial progenitor cell recruitment during wound neovascularization. J Invest Dermatol 126；1159-1167, 2006.
Asai J, Takenaka H, Kusano KF, Ii M, Luedemann C, Curry C, Eaton E, Iwakura A, Tsutsumi Y, Hamada H, Kishimoto S, Thorne T, Kishore R, Losordo DW. Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling. Circulation 113（20）；2413-2424, 2006.

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e-mail: massan@koto.kpu-m.ac.jp

http://kpum-dermatology.jp/