Professor Toshiki Mizuno

 

 

 Our research interests include diverse classes of neurological disorders, such as dementias, cerebrovascular diseases, neurodegenerative diseases, and neuromuscular diseases. We have been undertaking diagnostic studies on wide variety of dementias including Alzheimer disease, hereditary vascular dementias, and idiopathic normal pressure hydrocephalus (iNPH) by different modalities of neuroradiological investigations (SPECT, PET, and diffusion-weighted MR imaging), protein analysis on amyloid, tau, and TDP-43 proteins, and genetic analysis. On cerebrovascular diseases, we have been investigating part of the pathogenesis using fiber-tracking method, and also the therapeutic possibilities on selective cerebral hypothermia. Other research topics encompasses Parkinson disease, spinocerebellar degeneration, amyotrophic lateral sclerosis, Charcot-Marie-Tooth disease, mitochondrial diseases, Alexander disease, HTLV-I associated myelopathy and diverse types of myopathies. Our department also covers the research on cognitive impairment due to dementia and stroke and the studies on reward and dopaminergic system. In addition, our clinical service division offers genetic counseling, genetic testing, and pathological diagnosis on muscle biopsies.

 

1.Koizumi T, Taguchi K, Mizuta I, et al. Transiently proliferating perivascular microglia harbor M1 type and precede cerebrovascular changes in a chronic hypertension model. J Neuroinflammation 2019;16:79.

2.Kasai T, Kojima Y, Ohmichi T, et al. Combined use of CSF NfL and CSF TDP-43 improves diagnostic performance in ALS. Annals of clinical and translational neurology 2019;6:2489-2502.

3.Ohara T, Uehara T, Sato S, et al. Small vessel occlusion is a high-risk etiology for early recurrent stroke after transient ischemic attack. Int J Stroke 2019;14:871-877.

4.Ohmichi T, Mitsuhashi M, Tatebe H, et al. Quantification of brain-derived extracellular vesicles in plasma as a biomarker to diagnose Parkinson's and related diseases. Parkinsonism Relat Disord 2019;61:82-87.

5.Yasuda R, Nakano M, Yoshida T, et al. Towards genomic database of Alexander disease to identify variations modifying disease phenotype. Sci Rep 2019;9:14763.

6.Shinomoto M, Kasai T, Tatebe H, et al. Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients. PLoS One 2019;14:e0211575.

7.Koizumi T, Kerkhofs D, Mizuno T, et al. Vessel-Associated Immune Cells in Cerebrovascular Diseases: From Perivascular Macrophages to Vessel-Associated Microglia. Front Neurosci 2019;13:1291.

8.Makita N, Yamamoto Y, Nagakane Y, et al. Stroke mechanisms and their correlation with functional outcome in medullary infarction. J Neurol Sci 2019;400:1-6.

9.Yoshida T, Mizuta I, Yasuda R, et al. Characteristics of cerebral lesions in adult-onset Alexander disease. Neurol Sci 2020;41:225-227.

10.Koizumi T, Yamamoto Y, Nagakane Y, et al. The anterior one third of the posterior limb of the internal capsule is also supplied by the anterior choroidal artery. J Neurol Sci 2019;406:116455.

11.Koizumi T, Mizuta I, Watanabe-Hosomi A, et al. The CADASIL Scale-J, A Modified Scale to Prioritize Access to Genetic Testing for Japanese CADASIL-Suspected Patients. J Stroke Cerebrovasc Dis 2019;28:1431-1439.

12.Niwa F, Mizuno T, Nakagawa M. Lifestyle improvement or anti-dementia drugs in Alzheimer's disease. Curr Med Res Opin 2019;35:925.