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Biochemistry and Molecular Biology

Subject Biochemistry and Molecular Biology
Tsukasa Okuda
Lecturer Tatsushi Yoshida
Lecturer Yasumichi Kuwahara
Assistant Professor Kenta Yamazaki
Assistant Professor Kenjiro Tadagaki
Research Contents
Department of Biochemistry and Molecular Biology studies biochemical, genetic, and molecular basis of human disorders.  Generation of genetically-engineered animals and their use to study gene function as well as to recapitulate human diseases are principal themes in the department (Figure). Although we are currently focusing on the investigation of the cellular mechanism of normal development and malignant transformation for hematopoietic tissues, our interest involves wide-variety of cellular behavior and disorders which are dealt with in medical science.



(1)Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. AML-1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84 (2): 321-330, 1996.

(2)Okuda T, Takeda K, Fujita Y, Nishimura M., Yagyu S, Yoshida M, Akira S, Downing JR, Abe T. Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy. Molecular and Cellular Biology, 20(1): 319-328, 2000.

(3)Nishimura M, Fukushima-Nakase Y, Fujita Y, Nakao M, Toda S, Kitamura N, Abe T, Okuda T. VWRPY-motif-dependent and -independent roles of AML1/Runx1 transcription factor in murine hematopoietic development. Blood, 103(2): 562-570, 2004.

(4)Fukushima-Nakase Y, Naoe Y, Taniuchi I, Hosoi H, Sugimoto T, Okuda T. Shared and distinct roles mediated through C-terminal subdomains of Acute Myeloid Leukemia/Runt-related transcription factor molecules in murine development. Blood, 105(11): 4298-4307, 2005.

(5)Setoguchi R, Tachibana M, Naoe Y, Muroi S, Akiyama K, Tezuka C, Okuda T, Taniuchi I Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T Cell Development.Science319(5864): 822-825, 2008.
Contact tel 81-75-251-5315(5316)
fax 81-75-213-2746
e-mail okuda@koto.kpu-m.ac.jp

602-8566 Kyoto-shi, Kamigyo-ku Kajii-cho,
Kawaramachi-Hirokoji, JAPAN