京都府立医科大学：Pediatrics

Subject

Pediatrics

Staff

Professor

Tomoko Iehara

Professor: Tomoko Iehara

Associate Professor: Shinji Akioka

Visiting Professor: Toshiyuki Itoi, Masashi Nishida, Akira Nishimura, Kitaro Kosaka

Lecturer: Toshihiko Imamura, Kunihiko Tsuchiya, Shinya Osone,

Hisakazu Nakajima, Akane Shikata, Kiyoshi Hirai, Akiko Misawa

Assistant Professor: Kazuyuki Ikeda, Tomohiro Chiyonobu, Michiko Aoyama,

Jun Mori, Shigeki Yagyu, Mitsuru Miyachi, Yo Kajiyama,

Yoko Kawai, Tatsuji Hasegawa, Takenori Tozawa,

Kanae Hashiguchi, Hideki Yoshida, Masashi Zuiki,

Hidechika Morimoto, Satoru Sugimoto, Norio Nakagawa,

Akimasa Tomida, Satoshi Miyagaki, Mariko Morimoto,

Hiroshi Maeda, Takayo Chihara

Research Contents

Division of child neurology: We conduct research regarding the pathological analysis and development of therapy using iPS cells specific to developmental and epileptic encephalopathy; the development of therapy using Drosophila model for neurodevelopmental disorders.

Division of endocrinology and metabolism: We do research about the development of anti-obesity, especially focusing on the activation of brown adipose tissue, genetic polymorphism of pediatric obesity, the involvement of nutrition on short stature and small for gestational age (SGA), and the involvement of renin-angiotensin system, especially ACE2/Ang1-7/MasR, on various pathologic condition.

Division of hematology, oncology and immunology: We do basic research to reveal leukemogenic mechanism and develop new therapy for acute leukemia. We are developing the gene diagnosis, such as detection of MYCN amplification in neuroblastoma using serum DNA and PAX3-FKHR fusion genes in rhabdomyosarcoma. We are studying the molecular target treatment of neuroblastoma, rhabdomyosarcoma and malignant rhabdoid tumor in childhood.

Division of neonatology: We are doing clinical research on long-term neurodevelopmental outcome of very low birth weight infants, the effects of developmental care on the growth of the preterm infants, prediction of neurodevelopmental outcome in preterm infants using brain diffusion weighted imaging, and stress assessment using heart rate variability in newborns.

Division of cardiology: We analyze the mechanism of severe Kawasaki disease (KD) using iPS cell technology, and also analyze characterization of the dental microbiota of KD by metagenomics analysis. We perform clinical research about KD vascular disorder and the onset of arteriosclerosis. We participate in multi-facilities collaborative investigation about diagnostic kit for KD, and genetic analysis of KD patients. We perform elucidation of the drug-related cardiotoxic risk factor based on the long-term follow-up of patients with childhood cancer. We analyzed kidney injury biomarkers after cardiac angiography in children with congenital heart disease.

Achievements

Kubo H, Yagyu S, Nakamura K, Yamashima K, Tomida A, Kikuchi K, Iehara T, Nakazawa Y, Hosoi H. Development of non-viral, ligand-dependent, EPHB4-specific chimeric antigen receptor T cells for treatment of rhabdomyosarcoma. Mol Ther Oncolytics 2021; 20: 646-658.
Sakaue S, Hasegawa T, Sakai K, Zen Y, Tozawa T, Chiyonobu T, Yamada K, Morimoto M, Hosoi H. Low-grade IVH in preterm infants causes cerebellar damage, motor, and cognitive impairment. Pediatr Int 2021 Mar 11. doi: 10.1111/ped.14691.
Tomii T, Imamura T, Tanaka K, Kato I, Mayumi A, Soma E, Yano M, Sakamoto K, Mikami T, Morita M, Kiyokawa N, Horibe K, Adachi S, Nakahata T, Takita J, Hosoi H. Leukemic cells expressing NCOR1-LYN are sensitive to dasatinib in vivo in a patient-derived xenograft mouse model. Leukemia 2020 Nov 16. doi: 10.1038/s41375-020-01091-3.
Takai A, Chiyonobu T, Ueoka I, Tanaka R, Tozawa T, Yoshida H, Morimoto M, Hosoi H, Yamaguchi M. A novel Drosophila model for neurodevelopmental disorders associated with Shwachman-Diamond syndrome. Neurosci Lett 2020 Nov 20;739:135449. doi: 10.1016/j.neulet.2020.135449.
Kuwahara Y, Iehara T, Ichise E, Katsumi Y, Ouchi K, Tsuchiya K, Miyachi M, Konishi E, Sasajima H, Nakamura S, Fumino S, Tajiri T, Johann PD, FrÜhwald MC, Yoshida T, Okuda T, Hosoi H. Novel two MRT cell lines established from multiple sites of a synchronous MRT patient. Anticancer Res 2020; 40: 6159-6170.
Sugimoto Y, Katsumi Y, Iehara T, Kaneda D, Tomoyasu C, Ouchi K, Yoshida H, Miyachi M, Yagyu S, Kikuchi K, Tsuchiya K, Kuwahara Y, Sakai T, Hosoi H. The novel histone deacetylase inhibitor, OBP-801, induces apoptosis in rhabdoid tumors by releasing the silencing of NOXA. Mol Cancer Ther 2020; 19: 1992-2000.
Kanayama T, Imamura T, Mayumi A, Soma E, Sakamoto K, Hayakawa F, Tanizawa A, Kiyokawa N, Hosoi H. Functional analysis of a novel fusion protein PAX5-KIDINS220 identified in a pediatric Ph-like ALL patient. Int J Hematol 2020; 112: 714-719.
Iehara T, Manabe A, Hosoi H. Statement on the prevention and treatment of COVID-19 in patients with pediatric cancer in Japan. Pediatr Blood Cancer 2020 Sep;67(9):e28440. doi: 10.1002/pbc.28440.
Ouchi K, Miyachi M, Yagyu S, Kikuchi K, Kuwahara Y, Tsuchiya K, Iehara T, Hosoi H.　Oncogenic role of HMGA2 in fusion-negative rhabdomyosarcoma cells. Cancer Cell Int 2020 May 24;20:192. doi: 10.1186/s12935-020-01282-z.
Hasegawa D, Imamura T, Yumura-Yagi K, Takahashi Y, Usami I, Suenobu SI, Nishimura S, Suzuki N, Hashii Y, Deguchi T, Moriya-Saito A, Kato K, Kosaka Y, Hirayama M, Iguchi A, Kawasaki H, Hori H, Sato A, Kudoh T, Nakahata T, Oda M, Hara J, Horibe K. Risk-adjusted therapy for pediatric non-t cell all improves outcomes for standard risk patients: results of JACLS ALL-02. Blood Cancer J 2020 Feb 27;10(2):23. doi: 10.1038/s41408-020-0287-4.
Hashiguchi K, Kuriyama N, Koyama T, Matsui D, Ozaki E, Hasegawa T, Tokuda S, Niwa F, Iwasa K, Watanabe I, Teramukai S, Kitawaki J, Watanabe Y, Uehara R, Hosoi H. Validity of stress assessment using heart-rate variability in newborns. Pediatr Int 2020 Jan 20. doi: 10.1111/ped.14149.
Kawabe Y, Mori J, Morimoto H, Yamaguchi M, Miyagaki S, Ota T, Tsuma Y, Fukuhara S, Nakajima H, Oudit GY, Hosoi H. ACE2 exerts anti-obesity effect via stimulating brown adipose tissue and induction of browning in white adipose tissue. Am J Physiol Endocrinol Metab 2019; 317: E1140-E1149.
Sakamoto K, Shiba N, Deguchi T, Kiyokawa N, Hashii Y, Moriya-Saito A, Tomizawa D, Taga T, Adachi S, Horibe K, Imamura T. Negative CD19 expression is associated with inferior relapse-free survival in children with RUNX1-RUNX1T1-positive acute myeloid leukaemia: results from the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 Study. Br J Haematol 2019; 187: 372-376.
Osone S, Fukushima K, Yano M, Kakazu M, Sano H, Kato Y, Shinkoda Y, Shinoda K, Mori N, Adachi S. Supportive care for hemostatic complications associated with pediatric leukemia: a national survey in Japan. Int J Hematol 2019; 110: 743-750.
Nishida M, Kubo S, Morishita Y, Nishikawa K, Ikeda K, Itoi T, Hosoi H. Kidney injury biomarkers after cardiac angiography in children with congenital heart disease. Congenit Heart Dis 2019; 14: 1087-1093.
Iehara T, Yagyu S, Gotoh T, Ouchi K, Yoshida H, Miyachi M, Kikuchi K, Sugimoto T, Hosoi H. A prospective evaluation of liquid biopsy for detecting MYCN amplification in neuroblastoma patients. Jpn J Clin Oncol 2019; 49: 743-748.
Iehara T, Yoneda A, Yokota I, Takahashi H, Teramukai S, Kamijyo T, Nakazawa A, Takimoto T, Kikuta A, Yagyu S, Ikeda H, Nakagawara A, Tajiri T. Results of a prospective clinical trial JN-L-10 using image-defined risk factors to inform surgical decisions for children with low-risk neuroblastoma disease: a report from the Japan Children's Cancer Group Neuroblastoma Committee. Pediatr Blood Cancer 2019; Nov; 66(11): e27914. doi: 10.1002/pbc.27914.
Akioka S. Interleukin-6 in juvenile idiopathic arthritis. Mod Rheumatol 2019; 29: 275-286.
Zen Y, Chiyonobu T, Yuge M, Yokota I, Morimoto M, Teramukai S, Hosoi H. Gender differences in occurrence of behavioral and emotional problems at the lower grades of elementary school: association with developmental and behavioral characteristics at 5 years. Brain Dev 2019; 41: 760-768.
Nakamura A, Ikeda K, Hamaoka K. Aetiological significance of infectious stimuli in Kawasaki Disease. Front Pediatr 2019 Jun 28;7:244. doi: 10.3389/fped.2019.00244.
Nakagawa N, Kikuchi K, Yagyu S, Miyachi M, Iehara T, Tajiri T, Sakai T, Hosoi H. Mutations in the RAS pathway as potential precision medicine targets in treatment of rhabdomyosarcoma. Biochem Biophys Res Commun 2019; 512: 524-530.
Fukuhara S, Nakajima H, Sugimoto S, Kodo K, Shigehara K, Morimoto H, Tsuma Y, Moroto M, Mori J, Kosaka K, Morimoto M, Hosoi H. High-fat diet accelerates extreme obesity with hyperphagia in female heterozygous Mecp2-null mice. PLoS One 2019 Jan 4; 14(1): e0210184. doi: 10.1371/journal.pone.0210184.
Tsuma Y, Mori J, Ota T, Kawabe Y, Morimoto H, Fukuhara S, Kodo K, Umemura A, Nakajima H, Hosoi H. Erythropoietin and long-acting erythropoiesis stimulating agent ameliorate non-alcoholic fatty liver disease by increasing lipolysis and decreasing lipogenesis via EPOR/STAT pathway. Biochem Biophys Res Commun 2019; 509: 306-313.
Tomoyasu C, Kikuchi K, Kaneda D, Yagyu S, Miyachi M, Tsuchiya K, Iehara T, Sakai T, Hosoi H. OBP‑801, a novel histone deacetylase inhibitor, induces m‑phase arrest and apoptosis in rhabdomyosarcoma cells. Oncol Rep 2019; 41: 643-649.

Contact

tel 81-75-251-5571
fax 81-75-252-1399

e-mail ped@koto.kpu-m.ac.jp