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Division of Preventive Medicine

 
Subject Division of Preventive Medicine
Staff
   
 
 Associate Professor     Yoshihiro Sowa
Lecturer                   Motoki Watanabe
Assistant Professor    Yosuke Iizumi
Assistant Professor  Mitsuharu Masuda
Research Contents

Development of novel chemoprevention and chemotherapy of cancer, which we termed "Gene-regulating chemoprevention" and "Gene-regulating chemotherapy" of cancer, based on regulation of gene expression by a variety of agents including food factors.
Development of combinational protocols based on molecular-targeting chemoprevention and chemotherapy of cancer.
Development of novel anti-cancer drugs and cancer preventive foods by academic-industrial collaboration.
Development of novel and unique cancer diagnostic instrument, which profiles enzyme activity and protein expression of clinical specimen, by academic-industrial collaboration.
Investigation of gene regulation mechanisms of tumor-suppressor genes, cell cycle-regulating genes, apoptosis-regulating genes and DNA repair-regulating genes.
Investigation of gene-regulation mechanisms of anti-cancer drugs and cancer preventive factors.
Investigation of gene-regulation mechanisms of chemical carcinogens and environmental carcinogens.
Development of novel cancer diagnostic technologies of malignancy, prognosis and sensitivity to anti-cancer drugs, based on protein profiling data.

Achievements
  •  Ishii, N., et al. Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity. Cancer Res., 73: 4050-60, 2013.
  • Shiraishi, T., et al. Tunicamycin enhances TRAIL-induced apoptosis in human prostate cancer cells. Cancer Res., 65: 6364-70, 2005.
  • Yoshida, T., et al. Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/Enhancer-binding protein homologous protein. Cancer Res., 65: 5662-7, 2005.
  • Nakano, K., et al. Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line. J. Biol. Chem., 272: 22199-206, 1997.
  • Ohtani-Fujita, N., et al. CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene. Oncogene, 8: 1063-7, 1993.
Contact

tel 81-75-251-5338
fax 81-75-241-0792
e-mail  prevpub@koto.kpu-m.ac.jp

HP

 

602-8566 Kyoto-shi, Kamigyo-ku Kajii-cho,
Kawaramachi-Hirokoji, JAPAN

Contact
TEL:075-251-5111
FAX:075-251-7093