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Division of Endocrinology Diabetes and Metabolism

Subject  Department of Endocrinology and Metabolism
Staff
Professor; Michiaki Fukui
 
 
Lecturer; Masahiro Yamazaki
Assistant Professor; Mai Asano
Assistant Professor; Masahide Hamaguchi
Lecturer; Emi Ushigome(Donated Fund Laboratory)
Research Contents
●Basic research
1.Analysis of the mechanism for the development of impaired glucose and lipid metabolism by androgen deficiency and evaluation of hormone replacement therapy on the suppressive effect for them
2.Analysis of the mechanism for the development of fatty liver and sarcopenia by androgen deficiency and evaluation of hormone replacement therapy on the suppressive effect for them
3. Kinetic analysis of natural immunity lymphoid cell (Innate Lymphoid cell, ILC) in the atherosclerotic plaque
 
●Clinical research
1. Cohort study in patients with type 2 diabetes
2. Cohort study of home blood pressure in patients with type 2 diabetes
3. Role of androgen for glucose metabolism and atherosclerosis in patients with type 2 diabetes
4. Clinical study of sleep and sarcadian rhythm
5. Cohort study in Oike clinic
6. Clinical study of SGLT2 inhibitor

 

Achievements
Sodium-chloride Difference and Metabolic Syndrome: A Population-based Large-scale Cohort Study. Intern Med. 2016;55(21):3085-3090.
 
The relationship between hepatic steatosis and skeletal muscle mass index in men with type 2 diabetes. Endocr J. 2016 Oct 29;63(10):877-884.
 
Transient remission of nonalcoholic fatty liver disease decreases the risk of incident type 2 diabetes mellitus in Japanese men. Eur J Gastroenterol Hepatol. 2016 Dec;28(12):1443-1449.
 
Relationship between skeletal muscle mass and hepatic fibrosis in patients with type 2 diabetes. Diabetes Metab. 2016 Sep 22. pii: S1262-3636(16)30474-8.
 
Relationship between limited joint mobility of the hand and diabetic foot risk in patients with type 2 diabetes. J Diabetes. 2016 Aug 16.
 
BMI history and risk of incident fatty liver: a population-based large-scale cohort study. Eur J Gastroenterol Hepatol. 2016 Oct;28(10):1188-93.
 
Impact of low-carbohydrate diet on renal function: a meta-analysis of over 1000 individuals from nine randomised controlled trials. Br J Nutr. 2016 Aug;116(4):632-8.
 
Impact of low-carbohydrate diet on body composition: meta-analysis of randomized controlled studies. Obes Rev. 2016 Jun;17(6):499-509.
 
Caffeine intake enhances the benefits of sodium glucose transporter 2 inhibitor. Diabetes Metab Res Rev. 2016 Oct;32(7):694-699.
 
Various patterns of disrupted daily rest-activity rhythmicity associated with diabetes.
J Sleep Res. 2016 Aug;25(4):426-37.
 
Which Measurement of Blood Pressure Is More Associated With Albuminuria in Patients With Type 2 Diabetes: Central Blood Pressure or Peripheral Blood Pressure? J Clin Hypertens (Greenwich). 2016 Aug;18(8):790-5.
 
Reply to: Serum high-sensitivity cardiac troponin T and coronary artery calcification. J Cardiovasc Comput Tomogr. 2016 Mar-Apr;10(2):e3-4.
 
Postprandial hyperglycemia was ameliorated by taking metformin 30 min before a meal than taking metformin with a meal; a randomized, open-label, crossover pilot study. Endocrine. 2016 May;52(2):271-6.
 
Triglycerides to high-density lipoprotein cholesterol ratio is an independent predictor of incident fatty liver; a population-based cohort study. Liver Int. 2016 May;36(5):713-20.
 
The impact of non-alcoholic fatty liver disease on incident type 2 diabetes mellitus in non-overweight individuals. Liver Int. 2016 Feb;36(2):275-83.
 
Response to 'Effect of metabolic components on incident type 2 diabetes mellitus in nonalcoholic fatty liver disease subjects'. Liver Int. 2016 Mar;36(3):462.
 
Comment on Shukla et al. Food Order Has a Significant Impact on Postprandial Glucose and Insulin Levels. Diabetes Care 2015;38:e98-e99.
 
Hemoglobin concentration and incident metabolic syndrome: a population-based large-scale cohort study. Endocrine. 2015 Nov;50(2):390-6.
 
Heart rate-corrected QT interval is a novel risk marker for the progression of albuminuria in people with Type 2 diabetes. Diabet Med. 2015 Sep;32(9):1221-6.
 
The novel association between red complex of oral microbe and body mass index in healthy Japanese: a population based cross-sectional study. J Clin Biochem Nutr. 2015 Sep;57(2):135-9.
 
Optimal home SBP targets for preventing the progression of diabetic nephropathy in patients with type 2 diabetes mellitus.  J. Hypertens. 2015 33(9): 1853-1859, 2015.
 
Lower vegetable protein intake and higher dietary acid load associated with lower carbohydrate intake are risk factors for metabolic syndrome in patients with type 2 diabetes: Post-hoc analysis of a cross-sectional study. J Diabetes Investig. 2015 Jul;6(4):465-72.
 
Effect of Brazilian green propolis in patients with type 2 diabetes: A double-blind randomized placebo-controlled study. Biomed Rep. 2015 May;3(3):355-360.
 
Association between Hemoglobin Concentration and the Progression or Development of Albuminuria in Diabetic Kidney Disease. PLoS One. 2015 May 29;10(5)
 
The PR interval and QRS duration could be predictors of renal function decline. Atherosclerosis. 2015 May;240(1):105-9.
 
Metabolically healthy obesity and risk of incident CKD. Clin J Am Soc Nephrol. 2015 Apr 7;10(4):578-83.
 
Modest alcohol consumption reduces the incidence of fatty liver in men: a population-based large-scale cohort study. J Gastroenterol Hepatol. 2015 Mar;30(3):546-52.
J Gastroenterol Hepatol. 2015 Mar;30(3):546-52.
 
High-sensitivity cardiac troponin T is associated with coronary artery calcification. J Cardiovasc Comput Tomogr. 2015 May-Jun;9(3):209-14.
 
Senescence marker protein-30/gluconolactonase deficiency exacerbates diabetic nephropathy through tubular injury in a mouse model of type 1 diabetes. J Diabetes Investig. 2015 Jan;6(1):35-43.
 
Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study. BMJ Open. 2014 Oct 3;4(10):e005413.
 
Factors affecting variability in home blood pressure in patients with type 2 diabetes: post hoc analysis of a cross-sectional multicenter study. J Hum Hypertens. 2014 Oct;28(10):594-9.
 
Maximum home systolic blood pressure is a useful indicator of arterial stiffness in patients with type 2 diabetes mellitus: post hoc analysis of a cross-sectional multicenter study. Diabetes Res Clin Pract. 2014 Sep;105(3):344-51.
 
Is home blood pressure reporting in patients with type 2 diabetes reliable?  Hypertens.  Res. 37: 741-745, 2014.
 
Low serum bilirubin concentration is a predictor of chronic kidney disease. Atherosclerosis. 2014 Jun;234(2):421-5.
 
Home-measured heart rate is associated with albuminuria in patients with type 2 diabetes mellitus: a post-hoc analysis of a cross-sectional multicenter study. Hypertens Res. 2014 Jun;37(6):533-7.
 
The inter-arm difference in systolic blood pressure is a novel risk marker for subclinical atherosclerosis in patients with type 2 diabetes. Hypertens Res. 2014 Jun;37(6):548-52.
 
Low serum potassium concentration is a predictor of chronic kidney disease. Int J Clin Pract. 2014 Jun;68(6):700-4.
 
Beneficial effect of calcium channel blockers on home blood pressure variability in the morning in patients with type 2 diabetes. J Diabetes Investig. 2013 Jul 8;4(4):399-404.
 
Visit-to-visit blood pressure variability is a novel risk factor for the development and
progression of diabetic nephropathy in patients with type 2 diabetes. Diabetes Care. 2013 Jul;36(7):1908-12.
 
Could home arterial stiffness index be a novel marker for arterial stiffness in patients with type 2 diabetes? Hypertens Res. 2013 Jul;36(7):645-9.
 
Effect of repaglinide versus glimepiride on daily blood glucose variability and changes in blood inflammatory and oxidative stress markers. Diabetol Metab Syndr. 2014 May 5;6:54.
 
Low serum bilirubin concentration is a novel risk factor for the development of albuminuria in patients with type 2 diabetes. Metabolism. 2014 Mar;63(3):409-14.
 
Clinical characteristics of patients who report incorrect data of home-measured blood pressure. Diabetes Care. 2014 Feb;37(2):e24-5.
 
Effect of eating vegetables before carbohydrates on glucose excursions in patients with type 2 diabetes. J Clin Biochem Nutr. 2014 Jan;54(1):7-11.
 
Visit-to-visit variability in systolic blood pressure is a novel risk factor for the progression of coronary artery calcification. Hypertens Res. 2013 Nov;36(11):996-9.
 
A difference in systolic blood pressure between arms is a novel predictor of the development and progression of diabetic nephropathy in patients with type 2 diabetes. Atherosclerosis. 2013 Oct;230(2):198-201.
 
Morning pulse pressure is associated more strongly with elevated albuminuria than systolic blood pressure in patients with type 2 diabetes mellitus: post hoc analysis of a cross-sectional multicenter study. Diabetes Res Clin Pract. 2013 Sep;101(3):270-7.
 
Effects of liraglutide on postprandial insulin and glucagon responses in Japanese patients with type 2 diabetes. J Clin Biochem Nutr. 2013 Jul;53(1):68-72.
 
LOX-1 is a novel marker for peripheral artery disease in patients with type 2 diabetes. Metabolism. 2013 Jul;62(7):935-8.
 
Testosterone deficiency induces markedly decreased serum triglycerides, increased small dense LDL, and hepatic steatosis mediated by dysregulation of lipid assembly and secretion in mice fed a high-fat diet. Metabolism. 2013 Jun;62(6):851-60.
 
Eating vegetables before carbohydrates improves postprandial glucose excursions. Diabet Med. 2013 Mar;30(3):370-2.
 
A difference in systolic blood pressure between arms and between lower limbs is a novel risk marker for diabetic nephropathy in patients with type 2 diabetes. Hypertens Res. 2013 May;36(5):403-7.
 
N-terminal pro-brain natriuretic peptide could be a marker of subclinical atherosclerosis in patients with type 2 diabetes. Heart Vessels. 2013 Mar;28(2):151-6.
 
Home blood pressure variability on one occasion is a novel factor associated with arterial stiffness in patients with type 2 diabetes. Hypertens Res. 2013 Mar;36(3):219-25.
 
Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes. Endocr J. 2013;60(2):161-6.
Contact TEL: +81-75-251-5505
FAX: +81-75-252-3721
e-mail:y-nai@koto.kpu-m.ac.jp
HP

602-8566 Kyoto-shi, Kamigyo-ku Kajii-cho,
Kawaramachi-Hirokoji, JAPAN

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TEL:075-251-5111
FAX:075-251-7093