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Division of Neurology and Gerontology

Subject Division of Neurology and Gerontology
Toshiki Mizuno
Associate Professor Takahiko Tokuda, Lecturer Tomokatsu Yoshida
Assistant Professor Ikuko Mizuta, Masaki Kondo, Takashi Kasai, Tomoyuki Ohara,Akihiro Tanaka,Takahiro Yamada, Ryotaro Ishii, Hidetaka Koizumi
Research Contents
 Our research interests include diverse classes of neurological disorders, such as dementias, cerebrovascular diseases, neurodegenerative diseases, and neuromuscular diseases. We have been undertaking diagnostic studies on wide variety of dementias including Alzheimer disease, hereditary vascular dementias, and idiopathic normal pressure hydrocephalus (iNPH) by different modalities of neuroradiological investigations (SPECT, PET, and diffusion-weighted MR imaging), protein analysis on amyloid, tau, and TDP-43 proteins, and genetic analysis. On cerebrovascular diseases, we have been investigating part of the pathogenesis using fiber-tracking method, and also the therapeutic possibilities on selective cerebral hypothermia. Other research topics encompasses Parkinson disease, spinocerebellar degeneration, amyotrophic lateral sclerosis, Charcot-Marie-Tooth disease, mitochondrial diseases, Alexander disease, HTLV-I associated myelopathy and diverse types of myopathies. Our department also covers the research on cognitive impairment due to dementia and stroke and the studies on reward and dopaminergic system. In addition, our clinical service division offers genetic counseling, genetic testing, and pathological diagnosis on muscle biopsies.
An Adult Case of Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Multiphasic Acute Disseminated Encephalomyelitis at 33-year Intervals.
Numa S, Kasai T, Kondo T, Kushimura Y, Kimura A, Takahashi H, Morita K, Tanaka A, Noto Y, Ohara T, Nakagawa M, Mizuno T.
Intern Med. 2016;55:699-702.
Does hand dominance affect peripheral nerve excitability?
Tsuji Y, Noto Y, Shiga K, Yokota I, Nakagawa M, Mizuno T.
Clin Neurophysiol. 2016 ;127:1921-2.
Serum Levels of Coenzyme Q10 in Patients with Multiple System Atrophy.
Kasai T, Tokuda T, Ohmichi T, Ishii R, Tatebe H, Nakagawa M, Mizuno T.
PLoS One. 2016;11:e0147574.
Progressive multifocal leukoencephalopathy developing after liver transplantation showing marked neurological symptom improvement and arrest of further deterioration of imaging findings: A case report.
Yoshida T, Kawamoto M, Togo M, Kohara N, Ito T, Nakamichi K, Saijo M, Mizuno T.
J Neurol Sci. 2015 ;359:1-3.
CD62-mediated activation of platelets in cerebral white matter lesions in patients with cognitive decline.
Kuriyama N, Mizuno T, Yasuike H, Matsuno H, Kawashita E, Tamura A, Ozaki E, Matsui D, Watanabe I, Koyama T, Miyatani F, Kondo M, Tokuda T, Ohshima Y, Muranishi M, Akazawa K, Takada A, Takeda K, Matsumoto S, Mizuno S, Yamada K, Nakagawa M, Watanabe Y.
Arch Gerontol Geriatr. 2016 ;62:118-24.
Very prolonged capsular warning syndrome.
Makita N, Yamamoto Y, Nagakane Y, Ashida S, Mizuno T.
J Neurol Sci. 2015 ;352:115-6.
Decrease in plasma levels of α-synuclein is evident in patients with Parkinson's disease after elimination of heterophilic antibody interference.
Ishii R, Tokuda T, Tatebe H, Ohmichi T, Kasai T, Nakagawa M, Mizuno T, El-Agnaf OM.
PLoS One. 2015 ;10:e0123162.
Ultrasound in the diagnosis of peripheral neuropathy: structure meets function in the neuromuscular clinic.
Gallardo E, Noto Y, Simon NG.
J Neurol Neurosurg Psychiatry. 2015:1066-74.
Early Stroke Risk after Transient Ischemic Attack in Patients without Large-Artery Disease or Atrial Fibrillation.
Ohara T, Uehara T, Toyoda K, Suzuki R, Sato S, Nagatsuka K, Minematsu K.
J Stroke Cerebrovasc Dis. 2015 ;24:1656-61.
Noto Y, Shiga K, Tsuji Y, Mizuta I, Higuchi Y, Hashiguchi A, Takashima H,
Nakagawa M, Mizuno T.
Nerve ultrasound depicts peripheral nerve enlargement in patients with
genetically distinct Charcot-Marie-Tooth disease.
J Neurol Neurosurg Psychiatry. 86.378-84.2014
Noto Y, Shiga K, Tsuji Y, Kondo M, Tokuda T, Mizuno T,
Nakagawa M.
Contrasting echogenicity in flexor digitorum profundus-flexor carpi
ulnaris: a diagnostic ultrasound pattern in
sporadic inclusion body myositis. Muscle Nerve.49:745-8. 2014
Azuma Y, Tokuda T, Shimamura M, Kyotani A, Sasayama H, Yoshida T, Mizuta I, Mizuno T, Nakagawa M, Fujikake N, Ueyama M, Nagai Y, Yamaguchi M. Identification of ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS.
Hum Mol Genet. 23: 3467-80. 2014
Kasai T,  Tokuda T, Ishii R, Ishigami R, Tsuboi Y, Nakagawa M, Mizuno T, El-Agnaf OMA, Increased α-synuclein levels in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
J Neurol. 26:11203-9. 2014
Tamura A, Kasai T, Akazawa K, Nagakane Y, Yoshida T, Fujiwara Y, Kuriyama N, Yamada K, Mizuno T, Nakagawa M. Long insular artery infarction: characteristics of a previously unrecognized entity.
AJNR Am J Neuroradiol. 35:466-71. 2014
Impact of chronic kidney disease on carotid atherosclerosis according to blood pressure category: the Suita study.
Ohara T, Kokubo Y, Toyoda K, Watanabe M, Koga M, Nakamura S, Nagatsuka K, Minematsu K, Nakagawa M, Miyamoto Y.
Stroke. 2013 ;44:3537-9.
Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease.
Tokuda T, Qureshi MM, Ardah MT, Varghese S, Shehab SA, Kasai T, Ishigami N, Tamaoka A, Nakagawa M, El-Agnaf OM. Neurology. 2010 ;75:1766-72.
Retrograde jugular flow associated with idiopathic normal pressure hydrocephalus.
Kuriyama N, Tokuda T, Miyamoto J, Takayasu N, Kondo M, Nakagawa M.
Ann Neurol. 2008 ;64:217-21.
Contact tel 81-75-251-5793
fax 81-75-211-8645
E-mail neurokpu@koto.kpu-m.ac.jp
HP http://www.neurology-kpum.com/

602-8566 Kyoto-shi, Kamigyo-ku Kajii-cho,
Kawaramachi-Hirokoji, JAPAN