Lecturer Toshiro Yamamoto
Assistant Professor Takeshi Amamiya,Fumishige Osako,Masaru Nishigaki
|Research Contents||・Research into the relationships between oral diseases and systemic diseases (diabetes, obesity etc).
・Regenerative surgery for oral diseases using the amniotic membrane.
・Pathologic conditions of the mechanical stress and periodontal pathogens on periapical and periodontal lesions.
・Study of the infection to periodontal infection (apical periodontitis, marginal periodontitis) by medical transplantation.
・Epidemiological involvement of smoking in periodontal diseases.
As the dental department of a medical university, we are are not limited to our own department. We work together with other departments through joint research, with as central theme the exploration of the “association of the oral cavity with systemic disorders”.
In the field of basic medicine, we are conducting joint studies on the “pathologic conditions of periapical and periodontal lesions” with the Departments of Immunology, Microbiology, Orthopaedics, and Pathology. On the “epidemiological involvement of smoking and metabolic syndrome in periodontal diseases, relationship between cerebral microbleeds and oral bacteria” we cooperate with the Department of Health Science and Preventive Medicine. And there is a joint study with the Department of Physiology on the "analysis of taste" and "circadian rhytm and tooth formation".
In the field of clinical medicine, we are engaged in joint research on “regenerative surgery for oral diseases using the amniotic membrane” with the Department of Ophthalmology. On the “relationships between periodontal diseases and diabetes” with the Department of Endocrinology and Metabolism. And on the "relationship between oral bacteria and Kawasaki disease" with the Department of Pathology.
Concerning regenerative medicine, with a subsidy for highly-advanced medicine granted by the university, we developed a cultured human oral epithelial cell sheet based on the amniotic membrane, clinically applied it to epithelium-deficient cases, and obtained favorable results. As for the relationships between periodontal diseases and diabetes, we are providing periodontal treatment for diabetic patients to help them to more effectively control their blood glucose levels.
1. Aoki M, Watanabe Y, Yoshimoto K, Tsujimura A,
Yamamoto T, Kanamura N, Tanaka M.
Involvement of serotonin 2C receptor RNA editing in accumbal neuropeptide Y expression and behavioural despair.Eur J Neurosci 43: 1219-1228, 2016.
2. Ichioka H, Yamamoto T, Yamamoto K, Honjo K, Adachi T, Oseko F, Mazda O, Kanamura N, Kita M. Biomechanical force induces the growth factor production in human periodontal ligament-derived cells. Odontology 104: 27-34, 2016.
3. Yamamoto K, Yamamoto T, Honjo K, Ichioka H, Oseko F,
Mazda O, Kanamura N.
Electrical stimulation with periodic alternating intervals stimulates neuronal cells to produce neurotrophins and cytokines through activation of MAPK pathways.Eur J Oral Sci 123: 403-408, 2015.
4. Miyatani F, Kuriyama N, Watanabe I, Nomura R, Nakano K, Matsui D, Ozaki E, Koyama T, Nishigaki M, Yamamoto T, Mizuno T, Tamura A, Akazawa K, Takada A, Takeda K, Yamada K, Nakagawa M, Ihara M, Kanamura N, Friedland PR, Watanabe Y.
Relationship between Cnm-positive Streptococcus mutansand cerebral microbleeds in humans. Oral Dis 21: 886-893, 2015.
5. Yamamoto K, Kishida T, Sato Y, Nishioka K, Ejima A, Fujiwara H, Kubo T, Yamamoto T, Kanamura N, Mazda O. Direct conversion of human fibroblasts into functional osteoblasts by defined factors. Proc Natl Acad Sci USA 112: 6152-6157, 2015．
6. Adachi T, Pezzotti G, Yamamoto T, Ichioka H, Boffelli M,
Zhu W, Kanamura N.
Vibrational algorithms for quantitative crystallographic analyses of hydroxyapatite-based biomaterials：ⅡApplication to decayed human teeth.Anal Bioanal Chem 407: 3343-3356, 2015.
7. Amemiya T, Nakamura T, Yamamoto T, Kinoshita S, Kanamura N. Autologous transplantation of oral mucosal epithelial cell sheets cultured on an amniotic membrane substrate for intraoral mucosal defects. PLos One 10：e0125391, 2015.
8. Honjo K, Yamamoto T, Adachi T, Amemiya T, Kita M, Kanamura N, Mazda O. Evaluation of a dental pulp-derived cell sheet cultured on amniotic membrane substrate. Biomed Mater Eng 25：203-212, 2015.
9. Yamamoto T, Kimura I, Goto K, Kubota T, Hasegawa A, Murayama T, Nakai M, Kanamura N. Hydrocortisone irrigation in the management of sialodochitis Fibrinosa.
Journal of Japanese Socoety of Dentistry for Medically Compromised Patient 23: 80-83, 2014．
10. Adachi K, Amemiya T, Nakamura T, Honji K, Kumamoto S, Yamamoto T, Bentley AJ, Fullwood NJ, Kinoshita S, Kanamura N. Human periodontal ligament cell sheets cultured on amniotic membrane substrate. Oral Dis 20: 581-590, 2014.
11. Nishigaki M, Yamamoto T, Ichioka H, Honjo K, Yamamoto K, Oseko F, Kita M, Mazda O, Kanamura N. β-cryptoxanthin regulates bone resorption related-cytokine production in human periodontal ligament cells. Arch Oral Biol 58: 880-886, 2013.
12. Katagiri S, Nitta H, Nagasawa T, Izumi Y, Kanazawa M, Matsuo A, Chiba H, Fukui M, Nakamura N, Oseko F, Kanamura N, Inagaki K, Noguchi T, Naruse K, Matsubara T, Miyazaki S, Miyauchi T, Ando Y, Hanada N, Inoue S. Effect of glycemic control on periodontitis in type 2 diabetic patients with periodontal disease. J Diabetes Investig 4: 320-325, 2013.
13. Yamamoto T, Kita M, Mori M, Akamatsu Y, Ichioka H, Iehara T, Hosoi H, Kanamura N. Anti-tumor chemotherapeutic agents induce developmental disorders of tooth germ. Asian J Oral Maxillofac Surg 24: 208-212, 2012.
14. Kanamura N, Amemiya T, Yamamoto T, Mishima K, Saito M,
Tsuji T, Nakamura T.
Dental regenerative active therapy using oral tissues. Anti-Aging Medicine 9: 14-23, 2012.
15. Yamamoto K, Yamamoto T, Kanamura N, Kita M. Role of mechanical stress in mandible bone metabolism. Iflamm Regen 32: 119-123, 2012.