• Textsize Middle
  • Textsize Large






Department of Otolaryngology-Head and Neck Surgery

Subject Department of Otolaryngology-Head and Neck Surgery
Professor: Shigeru Hirano
Associate Professor:Hirofumi Sakaguchi
Lecturer:Makoto Yasuda
Assistant Professor:Masakatsu Taki,Yoichiro Sugiyama, Akihito Arai, Hikaru Nagao, Takahiro Tsujikawa, Mari Takenaka
Research Contents
In our department, research is conducted by four major subgroups; otology, rhinology, laryngology, and head and neck cancer. The current areas of interest are as follows.


Mechanisms of the inner ear homeostasis.

Mechanisms of the EP (endocochlear potential) generation.
Ultrastructure and molecular components of the stereocilia.
Physiology of the vestibular and oculomotor systems.
A novel therapeutic approach for allergic rhinitis using cytokines.
Ion transport in the nasal and sinus membrane.
Intercellular signaling in the nasal and sinus membrane via gap junctions.
Protection of the ambiguous nuclei neurons after nerve damage.
Function of clock genes in the larynx.
Function of nociceptors in the larynx.

Head and Neck Cancer
Immunogene therapy for squamous cell carcinoma.
Function of the p53 suppressor genes on tumor cell proliferation.
Clinical and pathological study in molecules related to the cervical lymph node metastasis.
Mukudai S, Matsuda K, Bando H, Takanami K, Nishio T, Sugiyama Y, Hisa Y, Kawata M. Expression of sex steroid hormone receptors in vagal motor neurons innervating the trachea and esophagus in mouse. Acta Histochem Cytochem 2016; 49: 37-46

Kamitani T, Sakaguchi H, Tamura A, Miyashita T, Yamazaki Y, Tokumasu R, Inamoto R, Matsubara A, Mori N, Hisa Y, Tsukita S.
Deletion of tricellulin causes progressive hearing loss associated with degeneration of cochlear hair cells. Sci Rep 2015; 5: 18402

Sugiyama Y, Shiba K, Mukudai S, Umezaki T, Sakaguchi H, Hisa Y. Role of the retrotrapezoid nucleus/parafacial respiratory group in coughing and swallowing in guinea pigs. J Neurophysiol 2015; 114: 1792-805

Lehnen N, Heuser F, Sağlam M, Schulz CM, Wagner KJ, Taki M, Kochs EF, Jahn K, Brandt T, Glasauer S, Schneider E. Opioid-induced nausea involves a vestibular problem preventable by head-rest. PLoS One 2015; 10: e0135263

Mukudai S, Matsuda KI, Nishio T, Sugiyama Y, Bando H, Hirota R, Sakaguchi H, Hisa Y, Kawata M. Differential responses to steroid hormones in fibroblasts from the vocal fold, trachea, and esophagus. Endocrinology 2015; 156: 1000-9

Ohmura G, Tsujikawa T, Yaguchi T, Kawamura N, Mikami S, Sugiyama J, Nakamura K, Kobayashi A, Iwata T, Nakano H, Shimada T, Hisa Y, Kawakami Y. Aberrant Myosin 1b Expression Promotes Cell Migration and Lymph Node Metastasis of HNSCC. Mol Cancer Res 2015; 13: 721-31

Kobayashi M, Nakamura T, Yasuda M, Hata Y, Okura S, Iwamoto M, Nagata M, Fullwood NJ, Koizumi N, Hisa Y, Kinoshita S. Ocular surface reconstruction with a tissue-engineered nasal mucosal epithelial cell sheet for the treatment of severe ocular surface diseases. Stem Cells Transl Med 2015; 4: 99-109
Contact tel 81-75-251-5603
fax 81-75-251-5604
e-mail jibisec@koto.kpu-m.ac.jp
HP http://www.f.kpu-m.ac.jp/k/ent/index-e.html

602-8566 Kyoto-shi, Kamigyo-ku Kajii-cho,
Kawaramachi-Hirokoji, JAPAN