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Division of Molecular Cell Physiology

Subject Division of Molecular Cell Physiology
Staff

Professor 

Akiyuki Taruno

 
Assistant Professor             Kengo Nomura
Assistant Professor             Shogo Soma
Project Researcher             Tatsuro Murakami
 
Research Contents
 
Achievements
1.Kashio M, Wei-Qi G, Ohsaki Y, Kido MA, Taruno A*(corresponding author). CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells. Sci Rep 9; 2681, 2019.
 
2.Taruno A*(corresponding author).ATP release channels. Int J Mol Sci 19; 808, 2018.
 
3.Ma Z#, Taruno A#(Co-first author), Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, Marunaka Y, Lee RJ, Hoff H, Payne R, Demuro A, Parker l, Mitchell C, Henao-Mejia J, Tanis JE, Matsumoto I, Tordoff MG, Foskett JK. CALHM3 is essential for rapid ion channel-mediated purinergic neurotransmission of GPCR-mediated tastes. Neuron 98; 547-561, 2018.
 
4.Taruno A*(corresponding author), Sun H, Nakajo K, Murakami T, Ohsaki Y, Kido M, Ono F, Marunaka Y. Post-translational palmitoylation controls the voltage gating and lipid raft association of CALHM1 channel. J Physiol 595; 6121-6145, 2017.
 
5.Taruno A*(corresponding author), Kashio M, Sun H, Kobayashi K, Sano H, Nambu A, Marunaka Y. Adeno-associated virus-mediated gene transfer into taste cells in vivo. Chem Senses 42; 69-78, 2017.
 
6.Taruno A*(corresponding author), Marunaka Y. Hypotonicity activates a voltage-dependent membrane conductance in N2a neuroblastoma cells. Biochem Biophys Res Commun 482; 331-335, 2017.
 
7.Nomura T, Taruno A#(Co-first author), Shiraishi M, Nakahari T, Inui T, Sokabe M, Eaton DC, Marunaka Y. Current-direction/amplitude-dependent single channel gating kinetics of mouse pannexin 1 channel: a new concept for gating kinetics. Sci Rep 7; 10512, 2017.
 
8.Ma Z, Tanis JE, Taruno A, Foskett JK. Calcium homeostasis modulator (CALHM) ion channels. Pflugers Arch 468; 395-403, 2016.
 
9.Taruno A*(corresponding author), Matsumoto I, Ma Z, Marambaud P, Foskett JK. How do taste cells lacking synapses mediate neurotransmission? CALHM1, a voltage-gated ATP channel. BioEssays 35; 1111-1118, 2013.
 
10.Taruno A, Vingtdeux V, Ohmoto M, Ma Z, Dvoryanchikov G, Li A, Adrien L, Zhao H, Leung S, Abernethy M, Koppel J, Davies P, Civan M M, Chaudhari N, Matsumoto I, Hellekant G, Tordoff MG, Marambaud P, Foskett JK. CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature 495; 223-226, 2013.
 
11.Taruno A, Ohmori H, Kuba H. Inhibition of presynaptic Na+/K+-ATPase reduces readily releasable pool size at the avian end-bulb of Held synapse. Neurosci Res 72; 117-128, 2012.
 
12.Taruno A, Marunaka Y. Analysis of blocker-labeled channels reveals the dependence of recycling rates of ENaC on the total amount of recycled channels. Cell Physiol Biochem 26; 925-934, 2010.
 
13.Taruno A, Niisato N, Marunaka Y. Intracellular calcium plays a role as the second messenger of hypotonic stress in gene regulation of SGK1 and ENaC in renal epithelial A6 cells. Am J Physiol Renal Physiol 294; F177-186, 2008.
 
14. Taruno A, Niisato N, Marunaka Y. Hypotonicity stimulates renal epithelial sodium transport by activating JNK via receptor tyrosine kinases. Am J Physiol Renal Physiol 293; F128-138, 2007.
Contact

tel 81-75-251-5311
fax  81-75-251-0295
e-mail  taruno@koto.kpu-m.ac.jp

HP

http://kpum-molecular-cell-physiology.info/english/index.html

602-8566 Kyoto-shi, Kamigyo-ku Kajii-cho,
Kawaramachi-Hirokoji, JAPAN

Contact
TEL:075-251-5111
FAX:075-251-7093