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Division of Pathology and Cell Regulation

Subject Division of Pathology and Cell Regulation
Professor Hideo Tanaka
Associate Professor Yoshinori Harada
Lecturer Takehiro Ogata
Assistant Professor Ryuta Nakao
Assistant Professor Akihiro Nakamura
Assistant Professor Kentaro Mochizuki
Research Contents
  1. Visualization of dynamics of functional molecules in the heart for understanding mechanisms of heart diseases especially arrhythmias.
  2. Functional inactivation of target proteins by using non-linear optics, e.g., MP-CALI
  3. Elucidation of cellular functions by using advanced optics technologies
  4. Application of autofluorescence imaging for diagnosis of tumors
  5. Molecular imaging of living tissues (e.g., myocardial infarct) by Raman scattering light
  6. Detection of cancers by using 5-ALA, e.g., lymph-node metastasis and extension in tissues

 1. Systems Network Genomic Analysis Reveals Cardioprotective Effect of MURC/
Cavin-4 Deletion Against Ischemia/Reperfusion Injury. J. Am. Heart Assoc. 8, e012047 (2019).

2. Fluorescence-based discrimination of breast cancer cells by direct exposure to
5-aminolevulinic acid. Cancer Med. 2019 (Epub ahead of print).

3. Terbium ion as RNA tag for slide-free pathology with deep-ultraviolet excitation fluorescence. Sci. Rep. 9, 10745 (2019).

4. Raman spectroscopic histology using machine learning for nonalcoholic fatty
liver disease. FEBS Lett. 2019 (Epub ahead of print).

5. High-resolution Raman microscopic detection of follicular thyroid cancer cells
with unsupervised machine learning. J. Phys. Chem. B 123, 4358-4372 (2019).

6. High-throughput cell imaging and classification by narrowband and low-spectralresolution Raman microscopy. J. Phys. Chem. B 123, 2654-2661 (2019).

7. Bioconjugation strategy for cell surface labeling with gold nanostructures
designed for highly localized pH measurement. Nat. Commun. 9, 5278 (2018)

8. Label-free evaluation of myocardial infarct in surgically excised ventricular
myocardium by Raman spectroscopy. Sci. Rep. 8, 14671 (2018).

9. Deep-ultraviolet Raman scattering spectroscopy of monolayer WS2. Sci. Rep.

8,11398 (2018).

10. How to adjust endoscopic findings to histopathological findings of the stomach: a "histopathology-oriented" correspondence method helps to understand endoscopic findings. Gastric Cancer 21, 573-577 (2018).

11. Spatiotemporally non-uniform Ca2+ dynamics of cardiac Purkinje fibers in mouse myocardial infarct. J. Histochem. Cytochem. 65, 655-667 (2017).

12. Efficient fluorescence detection of protoporphyrin IX in metastatic lymph

nodes of murine colorectal cancer stained with indigo carmine. Photodiag. Photodyn. Therapy 19, 175-180 (2017).

13. Raman micro-spectroscopy as a viable tool to monitor and estimate the

ionic transport in epithelial cells. Sci. Rep. 7, 3395 (2017).

14. Label-free detection of myocardial ischaemia in the perfused rat heart by
spontaneous Raman spectroscopy. Sci. Rep. 7, 42401 (2017).

15. Rapid and accurate peripheral nerve imaging by multipoint Raman spectroscopy.Sci. Rep. 7, 845 (2017).

16. Histopathological characteristics of post-inflamed coronary arteries in

Kawasaki disease-like vasculitis of rabbits. Acta Histochem. Cytochem. 49, 29-36 (2016).

17. Recent advances in photodynamic diagnosis of gastric cancer using 5-
aminolevulinic acid. World J. Gastroenterol. 22,1289-1296 (2016).

18. Highly sensitive fluorescence detection of metastatic lymph nodes of

gastric cancer with photo-oxidation of protoporphyrin Ⅸ. Eur. J. Surg. Oncol. 42, 1236-1246(2016).

19. Simplified and optimized multispectral imaging for 5-ALA-based fluorescence
diagnosis of malignant lesions. Sci. Rep. 6, 25530 (2016).

20. ラマン散乱分光イメージング法による多色摺木版画の色材分子分布解析法の開発. 情報知識学会誌 26, 1-10 (2016).

21. Deep-UV biological imaging by lanthanide ion molecular protection.
Biomed. Opt. Express 7, 158-170 (2016).

22. How Dose the Ca2+-paradox injury induce contracture in the heart?
- A combined study of the intracelluar Ca2+ dynamics and cell structures in perfused rat hearts - Acta Histochem. Cytochem. 48, 1-8 (2015).

23. Highy efficient direct conversion of human fibroblasts to neuronal cells by
chemical compounds. J. Clin. Biochem. Nutr. 56, 166-170 (2015).

24. Interaction of Cx43 with Hsc70 regulates G1/S transition through CDK

inhibitor p27. Sci. Rep. 5,15365 (2015).

25. Ex vivo peripheral nerve detection of rats by spontaneous Raman spectroscopy.
Sci. Rep. 5, 17165 (2015).

26. Label-free evaluation of myocardinal infarction and its repair by spontaneous
Raman spectroscopy. Anal. Chem. 86, 6903-10 (2014).

27. The involvement of the vasa vasorum in the development of vasculitis in

animal model of Kawasaki disease.Pediatr. Rheumatol. 12, 12 (2014).

28. Photoacoustic microscopy using ultrashort pulses with two different pulse
durations. Opt. Express 22, 17063-17072 (2014).

29. Photodynamic diagnosis of metastatic lymph nodes using 5-aminolevulinic acid in mouse squamous cell carcinoma. J. Dermatol. Sci. 74, 171-173 (2014).

30. In vivo detection of rat colorectal cancers by using a dual-wavelength

excitation method. Acta Histochem. Cytochem. 47, 247-254 (2014).


tel 81-75-251-5322
fax 81-75-251-5353
e-mail hideotan@koto.kpu-m.ac.jp

602-8566 Kyoto-shi, Kamigyo-ku Kajii-cho,
Kawaramachi-Hirokoji, JAPAN