|Subject||Division of Biochemistry and Molecular Biology|
Lecturer Tatsushi Yoshida
Lecturer Yasumichi Kuwahara
Assistant Professor Kenta Yamazaki
Assistant Professor Kenjiro Tadagaki
Department of Biochemistry and Molecular Biology studies biochemical, genetic, and molecular basis of human disorders. Generation of genetically-engineered animals and their use to study gene function as well as to recapitulate human diseases are principal themes in the department (Figure). Although we are currently focusing on the investigation of the cellular mechanism of normal development and malignant transformation for hematopoietic tissues, our interest involves wide-variety of cellular behavior and disorders which are dealt with in medical science.
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(2)Okuda T, Takeda K, Fujita Y, Nishimura M., Yagyu S, Yoshida M, Akira S, Downing JR, Abe T. Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy. Molecular and Cellular Biology, 20(1): 319-328, 2000.
(3)Nishimura M, Fukushima-Nakase Y, Fujita Y, Nakao M, Toda S, Kitamura N, Abe T, Okuda T. VWRPY-motif-dependent and -independent roles of AML1/Runx1 transcription factor in murine hematopoietic development. Blood, 103(2): 562-570, 2004.
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