Division of Rheumatology and Allergology

Subject Division of Rheumatology and Allergology
Staff
Professor: Yutaka Kawahito
 
 
Lecturer: Masataka  Kohno
Assistant Professor: Makoto Wada
Assistant Professor:  Kazuki Fujioka
Research Contents
  1. Molecular mechanisms of inflammatory or autoimmune diseases
  2. Mechanisms of fibrosis
  3. Inflammation and atherosclerosis
  4. Functions of MDSC with immunological diseases
  5. Mechanisms of proliferating synovium with rheumatoid arthritis
  6. Abnormality of sugar chain with malignant or immunological diseases
Achievements
  • Nagahara H, YamamotoA,SenoT,Obayashi H,Kida T,Nakabayashi A, Kukida Y,Fujioka K,Fujii W,Murakami K,Kohno M,Kawahito Y.Allograft inflammatory factor-1 in the pothogenesis of bleomyein-inclued acute lung injury.Biosci Trends.10(1):47-53,2016.
  • Fujii W, Kawahito Y, Nagahara H, Kukita Y, Seno T, Yamamoto A, Kohno M, Oda R, Taniguchi D, Fujiwara H, Ejima A, Kishida T, Mazda O, Ashihara E. Monocarboxylate transporter 4, associated with the acidification of synovial fluid, is a novel therapeutic target for inflammatory arthritis. Arthritis Rheumatol.  67(11):2888-96,2015. 
  • Fujioka K, Kishida T, Ejima A, Yamamoto K, Fujii W, Murakami K, Seno T, Yamamoto A, Kohno M, Oda R, Yamamoto T, Fujiwara H, Kawahito Y, Mazda O. Inhibition of osteoclastogenesis by osteoblast-like cells genetically engineered to produce interleukin-10. Biochem Biophys Res Commun. 456(3):785-91, 2015.
  • MurakamiK, Kohno M, KadoyaM, NagaharaH, FujiiW, Seno T, YamamotoA, Oda R, Fujiwara H, KuboT, Morita S, Nakada H, Hla T, Kawahito Y. Knock out of S1P3 receptor signaling attenuates inflammation and fibrosis in bleomycin-induced lung injury mice model. Plos one. 2014. 9(9):e106792, 2014.
  • Kadoya M, Yamamoto A, Hamaguchi M, Obayashi H, Mizushima K, Ohta M, Seno T, Oda R, Fujiwara H, Kohno M, Kawahito Y. Allograft inflammatory factor-1 stimulates chemokine production and induces chemotaxis in human peripheral blood mononuclear cells. Biochem Biophys ResRes Commun.448(3):287-91, 2014
  • Fujii W, Ashihara E, Hirai H, Nagahara H, Kajitani N, Fujioka K, Murakami K, Seno T, Yamamoto A, Ishino H, Kohno M, Maekawa T, Kawahito Y. Myeloid-derived suppressor cells play crucial roles in the regulation of mouse collagen- induced arthritis. J Immunol. 191(3):1073-81, 2013.
  • Seno T, Hamaguchi M, Ashihara E, Kohno M, Ishino H, Yamamoto A, Kadoya M, Makamura K, Murakami K, Matoba S, Maekawa T, Kawahito Y. 15-Deoxy-Δ12,14 Prostaglandin J2 Reduces the Formation of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice. PLos one. 6(10):e25541, 2011.
  • Yamamoto A, Ashihara E, Nakagawa Y, Obayashi H, Ohta M, Hara H, Adachi T, Seno T, Kadoya M, Hamaguchi M, Ishino H, Kohno M, Maekawa T, Kawahito Y. Allograft inflammatory factor-1 is overexpressed and induces fibroblast chemotaxis in the skin of sclerodermatous GVHD in a murine model. Immunol Lett.135(1-2):144-50, 2011.
  • Ishino H, Kawahito Y, Hamaguchi M, Takeuchi N, Tokunaga D, Hojo T, Wada M, Yamamoto A, Kadoya M, Tsubouchi Y, Kohno M, Nakada H.Expression of Tn and sialyl Tn antigens in synovial tissues in rheumatoid arthritis. Clin Exp Rheumatol. 28:246-9, 2010.
  • Kawahito Y, Ichinose S, Sano H, Tsubouchi Y, Kohno M, Yoshikawa T, Tokunaga D, Hojo T, Harasawa R, Nakano T, Matsuda K. Mycoplasma fermentans glycolipid-antigen as a pathogen of rheumatoid arthritis. Biochem Biophys Res Commun. 369(2): 561-566, 2008.
  • Wada M, Kawahito Y, Kimura S, Kohno M, Ishino H, Kimura M, Omoto A, Yamamoto A, Hamaguchi M, Tsubouchi Y, Tokunaga D, Hojo T, Ashihara E, Maekawa T, Yoshikawa T. siRNA targeting PLK-1 induces apoptosis of synoviocytes in rheumatoid arthritis. Biochem Biophys Res Commun. 357(2): 353-359, 2007.
  • Kimura M, Kawahito Y, Obayashi H, Ohta M, Hara H, Adachi T, Tokunaga D, Hojo T, Hamaguchi M, Omoto A, Ishino H, Wada M, Kohno M, Tsubouchi Y, Yoshikawa T. A critical role for allograft inflammatory factor-1 in the pathogenesis of rheumatoid arthritis.J Immunol. 178(5): 3316-3322, 2007.
  • Omoto A, Kawahito Y, Prudovsky I, Tsubouchi Y, Kimura M, Ishino H, Wada M, Yoshida M, Kohno M, Yoshimura R, Yoshikawa T, Sano H. Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation- associated cachexia in rats. Arthritis Research & Therapy. 7(6): R1174-R1182, 2005.
  • Inaba T, Sano H, Kawahito Y, Hla T, Akita K, Toda M, Yamashina I, Inoue M, Nakada H. Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells. Proc Natl Acad Sci U S A. 100(5): 2736-2741, 2003.
  • Kohno M, Kawahito Y, Tsubouchi Y, Hashiramoto A, Yamada R, Inoue K, Kusaka Y, Kubo T, Elenkov IJ, Chrousos G.P, Kondo M, Sano H. Urocortin expression in synovium of patients with rheumatoid arthritis and osteoarthritis: relation to inflammatory activity. J Clin Endcrinol Metab. 86(9): 4344-4352, 2001.
  • Tsubouchi Y, Kawahito Y, Kohno M. Inoue K, Hla T, Sano H. Feedback control of the arachdonate cascade in rheumatoid synoviocytes by 15-deoxy-△12, 14-proaglandin J2. Biochem Biophys Res Commun. 283(4): 750-755, 2001.
  • Y, Kondo M, Tsubouchi Y, Hashiramoto A, Bishop-Bailey D, Inoue K, Kohno M, Yamada R, Hla T, Sano H. 15-deoxy-Δ12,14-PGJ2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. J Clin Invest. 106(2): 189-197, 2000.
Contact TEL +81-75-251-5505
FAX +81-75-252-3721
E-mail kawahity@koto.kpu-m.ac.jp
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