Department of Urology

Subject Department of Urology
Staff
Professor: Osamu Ukimura 
 
Associate Professor:
Fumiya Hongo
Lecturer:
Yasuyuki Naito, Astuko Fujihara 
 
Assistant Professor:
So Ushijima,Motohiro Kanazawa,
Takumi Shiraishi,Kei Suzuki,
Takeshi Yamada, Akihisa Ueno
Research Contents
Department of Urology, Kyoto Prefectural University of Medicine
University Hospital, Kyoto Prefectural University of Medicine is located at the center of the Japanese-thousand-years ancient capital, Kyoto, Japan. It is a beautiful historical place between the Kamogawa River and the Kyoto Imperial Palace.  At the east side over the scenic Kamo River, we can see Mount Hiei and Daimonji in the Higashiyama Mountain range. The Department of Urology of Kyoto Prefectural University of Medicine, was established in 1964 and has a history spanning over 50 years. I joined our department 28 years ago and since then over 140 urological members have been active at affiliated hospitals in mainly Kyoto as well as Shiga, and Osaka prefecture. We cherish “love of humanity”, “dream” and “harmonious cooperation” and are involved with medical care, research and human resource development.  Under the staffs of our department who all are board certified urologists, a lot of talented young urologists are gathering to create their own dreams and future.
 
Outpatient Care
Urology is a special field covering the organs of the urinary tract (kidney, ureter, bladder and urethra) and the male reproductive system (prostate, testis and penis etc.) The diseases related to the adrenal gland and the retroperitoneum are also an object for urology. There are a variety of diseases in the field of urology, such as urological cancers (prostate cancer, renal cancer, urothelial cancer and testicular cancer etc.) and urinary dysfunction (benign prostate hyperplasia, overactive bladder and urinary incontinence etc.). Furthermore, urology also encompasses female urology, pediatric urology, male sexual dysfunction, male infertility, urinary infection and urinary stone. In our department, professional staffs in each fields can manage a wide range of urological diseases in specialty outpatient clinic. A woman doctor is always in charge of outpatient clinic for female urology.
 
Medical and Surgical Treatment
Urology is a part of surgery and our department can offer a variety of options including the state-of-the-art treatment as well as the standardized medicine and surgery while considering the efficacy, safety and invasiveness of treatment, and quality of life for patients. For examples, there are a lot of options such as robot assisted surgery, laparoscopic surgery, endoscopic surgery, highly difficult open surgery, urinary diversion, percutaneous cancer targeted therapy, new medical treatment, new function-sparing therapy, the latest radiation therapy, active surveillance and palliative care. We can provide accurate information in order for patients to select the best option in their own situations. I believe that patients’ proactive decision (adherence) is one of the most important keys that leads to the success of the treatment.
 
Research
We have devoted ourselves to clinical and basic research in each specialized field, by which we have discovered innovative solutions to limitations of current medicine and newly emerged problems to be solved. As a consequence, we have discovered and reported the latest medical technology and the latest result of basic research, and made our best effort to internationally impact on the world. Our department can be characterized by our special environment and experience where we are able to conduct international exchange and collaborative research with foreign medical institutions.
Achievements
  1. Significant antitumoral activity of cationic multilamellar liposomes containing human IFN-beta gene against human renal cell carcinoma. Clin Cancer Res. 2003;9(3):1129-35.
  2. Neuroselective current perception threshold evaluation of bladder mucosal sensory function.  Eur Urol. 2004; 45:70-76.
  3. Real-time transrectal ultrasonography during laparoscopic radical prostatectomy.  J Urol. 2004; 172:112-118.
  4. Radio-frequency ablation of renal cell carcinoma in patients who were at significant risk. Int J Urol. 2004; 11:1051-1057.
  5. Visual analog scale questionnaire to assess quality of life specific to each symptom of the International Prostate Symptom Score. J Urol. 2006;176(2):665-71.
  6. Pictorial essay: real-time transrectal ultrasound guidance during nerve-sparing laparoscopic radical prostatectomy.  J Urol, 2006; 175:1311-1319.
  7. Real-time transrectal ultrasound guidance during nerve-sparing laparoscopic radical prostatectomy: Impact on surgical margins. J Urol, 2006;175:1304-1310.
  8. Real-time Virtual Sonographic Radiofrequency Ablation of Renal Cell Carcinoma.  BJU Int. 2008; 101:707-711.
  9. Image-fusion, augmented reality and predictive surgical navigation.  Urol Clin North Am 2009; 36:115-123.
  10. Myocardin functions as an effective inducer of growth arrest and differentiation in human uterine leiomyosarcoma cells. Cancer Res. 2010 15;70(2):501-11.
  11. Technique for a hybrid system of real-time transrectal ultrasound with preoperative magnetic resonanceimaging in the guidance of targeted prostate biopsy. Int J Urol. 17(10):890-3. 2010
  12. Innovations in Prostate Biopsy Strategies for Active Surveillance and Focal Therapy. Curr Opin Urol. 21(2): 115-120, 2011
  13. 3D Reconstruction of Renovascular-Tumor Anatomy to Facilitate Zero-Ischemia Laparoscopic and Robotic Partial Nephrectomy. Eur Urol 61: 211-217, 2012
  14. Three-Dimensional Elastic Registration System of Prostate Biopsy Location by Real-time 3-dimensional transrectal ultrasound guidance with magnetic resonance/transrectal ultrasound image fusion. J Urol. 187: 1080-1086, 2012
  15. Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival. Nat Med. 2012 Aug;18(8):1254-61.
  16. Hyper-expression of PAX2 in human metastatic prostate tumors and its role as a cancer promoter in an in vitro invasion model. Prostate. 2013;73(13):1403-12
  17. Contemporary role of systematic prostate biopsies: indications, technique, implications on patient care. Eur Urol. 2013;63(2):214-30
  18. Urge perception index of bladder hypersensitivity. J Urol. 2013 ;189(5):1797-803.
  19. Image-visibility of cancer to enhance targeting precision and spatial mapping biopsyfor focal therapy of prostate cancer. BJU Int 2013, 111(8):E354-64
  20. CDK1 and CDK2 activity is a strong predictor of renal cell carcinoma recurrence.Urol Oncol. 2014;32(8):1240-6.
  21. PAX2 promoted prostate cancer cell invasion through transcriptional regulation of HGF in an in vitro model. Biochim Biophys Acta. 2015;1852(11):2467-73.
  22. MRI-TRUS Image-fusion Biopsies Accurately Characterize the Index Tumor: Correlation with Step-sectioned Radical Prostatectomy Specimens in 135 Patients. Eur Urol 2015:67:787-794
  23. A novel technique using three-dimensionally documented biopsy mapping allows precise re-visiting of prostate cancer foci with serial surveillance of cell cycle progression gene panel. Prostate 2015 in press
  24. Importance of continuous sequential chemotherapy and multimodal treatment for advanced testicular cancer: a high-volume Japanese center experience. Medicine (Baltimore). 2015 ;94(11):e653.
  25. Three-dimensional Printed Model of Prostate Anatomy and Targeted Biopsy-proven Index Tumor to Facilitate Nerve-sparing Prostatectomy. Eur Urol. 2015 Sep in press
Contact
tel 81-75-251-5595
fax 81-75-251-5598
e-mail uro1@koto.kpu-m.ac.jp
HP http://kpum-urology.com/

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