Professor & Chairman Toshikazu Kubo
||Toshiharu Shirai, Yuji Arai, Daisaku Tokunaga, Toru Morihara, Kazuya Ikoma
Masateru Nagae, Ryu Terauchi,
Yoshinobu Oka, Masahiro Maki, Masashi Ishida
Hitoshi Tonomura, Ryota Takatori, Hiroaki Inoue, Tsuyoshi Goto, Masazumi Saito, Shinji Tsuchida, Shuji Nakagawa, Shogo Toyama, Yoshikazu Kida, Masamitsu Kido, Atsushi Nishida,
Kan Ooyabu, Shigeki Hayashi
||The field of orthopaedics covers the treatment of a wide range of patients of all ages with various joint disorders, including disorders of the hip, knee, foot, shoulder, and elbow, spinal disease, hand and peripheral nerve injuries, rheumatoid arthritis; osteoporosis, bone and soft-tissue tumors, fractures; and sports injuries. We engage in both basic and clinical research aiming to elucidate pathological conditions and to develop new methods of diagnosis and treatment for these disorders. Our research is funded not only publicly, by Grants-in-Aid for Scientific Research from the Ministry of Health, Labour and Welfare and by research funds from the Ministry of Education, Culture, Sports, Science and Education, but also privately, through the acquisition of various competitive funding sources. One of the representative research topics of our department is the piezoelectricity of bone, the elucidation of which was an outstanding achievement now engraved into the history of Japanese Orthopaedic Association. Another of our research theme is idiopathic osteonecrosis of the femoral head (ION): our department is a global leader for the prevention of steroid-induced ION (development of preventive method such as gene analysis and electromagnetic field stimulation, so on). Basic research is also being conducted in several other areas, including development of the new treatment method for osteoarthritis targeting HIF-1 alpha, comprehensive study concerning fracture healing and circadian rhythm, investigation of the reaction mechanism of chondroblasts under stress of physiological hypoxic environment, treatment of joint disorders using small interfering RNA, the promotion of regeneration of peripheral nerves and skeletal muscle, intervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres, and the anticancer or antimetastatic effect of bisphosphonate and sulforaphane, which target cancer-related genes and may help treat malignant bone and soft-tissue tumors. We are also conducting clinical research in several areas, namely, radial imaging as a method of evaluating the condition of the acetabular labrum in hip dysplasia, minimally invasive microscopic or microendoscopic muscle-preserving interlaminar decompression for lumbar spinal canal stenosis, 10 year epidemiological study of deformity in the rheumatoid hand, visualization of pain in lumber spinal canal stenosis using functional MRI of the brain, establishment of a new image analysis method for foot and ankle deformity. Through these studies, we aim to realize original research with a global impact.
- Microendoscopic decompression for degenerative spondylolisthesis – Clinical results and radiological assessment after more than 5 years of follow-up Mikami Y, Nagae M, Harada T, Tonomura H, Mizuno K, Nonomura M, Ishibashi H, Ikeda T, Kubo, T J Spine Res, 6: 11-114, 2015
- Relief of low back pain with decompression for lumbar spinal canal stenosis Nagae M, Mikami Y, Mori G, Kitanaka S, Harada T, Tonomura H, Fujiwara H, Sawada K, Ikeda T, Hase H, Kubo T J Spine Res, 6: 932-937, 2015
- Evaluation of segmental stability in muscle-preserving interlaminar decompression for lumbar spinal canal stenosis in patients with or without kissing spine Tonomura H, Hatta Y, Koike H, Nagae M, Sawada K, Ikeda T, Mikami Y, Hase H, Kubo T J Spine Res, 6: 942-946, 2015
- Okubo N, Fujiwara H, Minami Y, Kunimoto T, Hosokawa T, Umemura Y, Inokawa H, Asada M, Oda R, Kubo T, Yagita K Parathyroid hormone resets the cartilage circadian clock of the organ-cultured murine femur. Acta Orthop. 2015 86(5):627-31.
- Kan H, Arai Y, Nakagawa S, Inoue H, Minami G, Ikoma K, Fujiwara H, Kubo T. Arthroscopic microfracture technique for cartilage damage to the lateral condyle of the tibia, Case Rep Orthop. 2015:795-759
- Ikegami A et al. Femoral perfusion after electromagnetic field stimulation in a steroid-induced osteonecrosis model. Transaction of Orthopaedic Research Society. 2015: 832.
- Yamasaki T et al. Changes in central nervous system activity after peripheral nerve injury: A functional MRI study. Transaction of Orthopaedic Research Society. 2015: 1115.
- Nakase M et al. Early detection of growth plate change using MR images after growth plate injury. Transaction of Orthopaedic Research Society. 2015: 1272.
- Sukenari T et al. Analysis of signal-to-noise ratio on cortical bone of the ovariectomized rats at primary stage by using MRI with SWIFT technique. Transaction of Orthopaedic Research Society. 2015: 1462.
- Hayashi S et al. A trial to detect early degenerative changes of rabbit knee cartilage in vivo using MR imaging with a double-contrast agent. Transaction of Orthopaedic Research Society. 2015: 1976.
- In vivo evaluation of rabbit sciatic nerve regeneration with diffusion tensor imaging (DTI): correlations with histology and behavior. Yamasaki T, Fujiwara H, Oda R, Mikami Y, Ikeda T, Nagae M, Shirai T, Morisaki S, Ikoma K, Masugi-Tokita M, Yamada K, Kawata M, Kubo T. Magn Reson Imaging. 33, 95-101, 2015
- Evaluation of femoral perfusion in a rabbit model of steroid-induced osteonecrosis by dynamic contrast-enhanced mri with a high magnetic field MRI system. Hayashi S, Fujioka M, Ikoma K, Saito M, Ueshima K, Ishida M, Kuribayashi M, Ikegami A, Mazda O, Kubo T. J Magn Reson Imaging. 41, 935-40, 2015