Department of Pathology and Applied Neurobiology

Subject Department of Pathology and Applied Neurobiology
Professor Kyoko Itoh
  Takahiro Fujimoto,
: So Tando, Takeshi Yaoi,
   Hiroshi Ogi(Department of Interdisciplinary   Research of Development)
Research Contents

We, the Department of Pathology and Applied Neurobiology, would like to have freshmen to join our laboratory and to work with us to understand the pathology of nervous system.
We are involved in teaching basic pathology to the undergraduate students, whom we further provide with opportunities of studying autopsy cases including participation in clinico-pathological conferences as well as of publishing papers as co-authors in the international journals.
In the field of basic research, we have been studying pathogenesis of developmental brain disorders employing various methodologies including molecular biology, cell biology, biochemistry, histology, behavioral assays, and imaging. These researches have so far demonstrated the novel effects of an environmental chemical on brain development and the novel functional significance of the cell adhesion molecule L1CAM during cortical development. The publications on our research are listed below.
The structures as well as functions of human brain are complex and more efforts are needed to disclose the details even in the genomic era. By gaining more insight into the pathogenesis of developmental brain disorders, we are hoping to find ways which might be applicable for clinical treatment and/or prevention of human diseases.


Major research projects are as follows:
1) Molecular neurobiological as well as neuropathological studies on the pathogenesis of developmental brain disorders of humans, employing neural stem cells derived from the brains with disorders.
2) Studies on the functions of the cell adhesion molecule L1CAM, with special reference to brain development as well as tumor progression.
3) Molecular neuropathological studies on the animal models of human neurological disorders, including hereditary microcephaly type 5.
4) Molecular neurobiological studies on the neuronal type of dystrophin, Dp40.

5)Molecular and neuropathological studies on neurodegenerative disease, with special references to neurons and glia.

6)Development of novel methodology and apparatus for medical research by application of high-technology derived from different fields


Written by Kyoko Itoh


  1. Isogai E, Itoh K, Tando S, Fushiki S, Wakabayashi Y et al. Oncogenic Lmo3 cooperates with Hen2 to induce hydrocephalus in mice. Exp Anim 64: 407-414, 2015.
  2. Inoue K, Fujimura H, Ueda K, Matsumura T, Itoh K, Sakoda S. An autopsy case of neuronal intermediate filament inclusion disease with regard to immunophenotypic and topographical analysis of the neuronal inclusions. Neuropathogy 35: 545-552, 2015.
  3. Itoh K, Fushiki S. The role of L1cam in murine corticogenesis, and the pathogenesis of hydrocephalus. Pathol Int 65(2): 58-66, 2015.
  4. Ogi H, Itoh K, Ikegaya H, Fushiki S. Alterations of neurotransmitter norepinephrine and gamma-aminobutyric acid correlate with murine behavioral perturbations related to bisphenol A exposure. Brain Dev 37: 739-746, 2015
  5. Takeda K, Sowa Y, Nishino K, Itoh K, Fushiki S. Adipose-derived stem cells promote proliferation, migration, and tube formation of lymphatic endothel cells I vitro by secreting lymphangiogenetic factors. Ann Plas Surg 74: 728-736, 2015.
  6. Itoh K, Yagita K, Nozaki T, Katano H, Hasegawa H, Matsuo K, Hosokawa Y, Tando S, Fushiki S. An autopsy case of Balamuthia mandrillaris amoebic encephalitis, a rare emerging infectious disease, with a brief review of the cases reported in Japan. Neuropathology. 35(1):64-9, 2015.
  7. McLean SJ, Ikegaya H, Saukko PJ, Zheng HY, Itoh K, Fushiki S. The utilization of stable isotope analysis for the estimation of the geographic origins of unidentified cadavers. Forensic Sci Int 245: 45–50, 2014.
  8. Konno T, Tada M, Tada M, Koyama A, Nozaki H, Harigaya Y, Nishimiya J, Matsunaga A, Yoshikura N, Ishihara K, Arakawa M, Isami A, Okazaki K, Yokoo H, Itoh K, Yoneda M, Kawamura M, Inuzuka T, Takahashi H, Nishizawa M, Onodera O, Kakita A, Ikeuchi T. Haploinsufficiency of CSF-1R and clinicopathologic characterization in patients with HDLS. Neurology 82: 139-148, 2014.
  9. Tando S, Itoh K, Yaoi T, Ogi H, Goto S, Mori M, Fushiki S. Bisphenol A exposure disrupts the development of the locus coeruleus-noradrenergic system in mice. Neuropathology 34(6):527-34,2014.
  10. Dwianingsih EK, Malueka RG, Nishida A, Itoh K, Lee T, Yagi M, Iijima K, Takeshima Y, Matsuo M. A novel splicing silencer generated by DMD exon 45 deletion junction could explain upstream exon 44 skipping that modifies dystrophinopathy. J Hum Genet 59: 423-429, 2014.
  11. Fujimoto T, Itoh K, Yaoi T, Fushiki S. Somatodendritic and excitatory
    postsynaptic distribution of neuron-type dystrophin isoform, Dp40, in hippocampal
    neurons. Biochem Biophys Res Commun 452(1): 79-84, 2014.
  12. Tonosaki M, Itoh K, Umekage M, Kishimoto T, Yaoi T, Lemmon VP, Fushiki S. L1cam is crucial for cell locomotion and terminal translocation of the soma in radial migration during murine corticogenesis. PLoS One 9(1): e86186, 2014.
  13. Itoh K, Kasai T, Tsuji Y, Saito K, Mizuta I, Harada Y, Sudoh S, Mizuno T, Nakagawa M, Fushiki S. Definite familial multiple system atrophy with unknown genetics. Neuropathology 34(3): 309-13, 2014.
  14. Fujimori A, Itoh K, Goto S, Hirakawa H, Wang B, Kokubo T, Kito S, Tsukamoto S, Fushiki S. Disruption of Aspm causes microcephaly with abnormal neuronal differentiation. Brain Dev 36(8): 661-9, 2014.
  15. Yamada T, Itoh K, Matsuo K, Yamamoto Y, Hosokawa Y, Koizumi T, Shiga K, Mizuno T, Nakagawa M, Fushiki S. Concomitant alpha-synuclein pathology in an autopsy case of amyotrophic lateral sclerosis presenting with orthostatic hypotension and cardiac arrests. Neuropathology 34(2): 164-9, 2014.
  16. Ogi H, Itoh K, Fushiki S. Social behavior is perturbed in mice after exposure to bisphenol A:  a novel assessment employing an IntelliCage. Brain Behav 3(3): 223-8, 2013.
  17. Itoh K, Pooh R, Kanemura Y, Yamasaki M, Fushiki S. Brain malformation with loss of normal FGFR3 expression in thanatophoric dysplasia type I. Neuropathology 33(6): 663-6, 2013.
  18. Honda H, Ishii R, Hamano A, Itoh K, Suzuki SO, Fushiki S, Nakagawa M, Iwaki T.Microsphere formation in a subtype of Creutzfeldt-Jakob disease with a V180I mutation and codon 129 MM polymorphism. Neuropathol Appl Neurobiol 39(7): 844-8, 2013.
  19. Itoh K, Pooh R, Kanemura Y, Yamasaki M, Fushiki S. Hypoplasia of the spinal cord in a case of foetal akinesia/arthrogryposis sequences. Neuropathol Appl Neurobiol 39(4): 441-4, 2013.
  20. Sawai Y, Murata H, Horii M, Koto K, Matsui T, Horie N, Tsuji Y, Ashihara E, Maekawa T, Kubo T, Fushiki S. Effectiveness of sulforaphane as a radiosensitizerfor murine osteosarcoma cells. Oncol Rep 29(3): 941-5, 2013.
  21. Koto K, Murata H, Kimura S, Sawai Y, Horie N, Matsui T, Ryu K, Ashihara E, Maekawa T, Kubo T, Fushiki S. Zoledronic acid significantly enhances radiation‑induced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling. Int J Oncol 42(2): 525-34, 2013.
  22. Kishimoto T, Itoh K, Umekage M, Tonosaki M, Yaoi T, Fukui K, Lemmon VP, Fushiki S. Downregulation of L1 perturbs neuronal migration and alters the expression of transcription factors in murine neocortex. J Neurosci Res 91(1): 42-50, 2013.
  23. Tozawa T, Itoh K, Yaoi T, Tando S, Umekage M, Dai H, Hosoi H, Fushiki S. The shortest isoform of dystrophin (Dp40) interacts with a group of presynaptic proteins to form a presumptive novel complex in the mouse brain. Mol Neurobiol 45(2): 287-97, 2012.
  24. Itoh K, Yaoi T, Fushiki S. Bisphenol A, an endocrine-disrupting chemical, and brain development. Neuropathology 32(4): 447-57, 2012.
  25. Shimomura M, Yaoi T, Itoh K, Kato D, Terauchi K, Shimada J, Fushiki S. Drug resistance to paclitaxel is not only associated with ABCB1 mRNA expression but also with drug accumulation in intracellular compartments in human lung cancer cell lines. Int J Oncol 40(4): 995-1004, 2012.
  26. Sowa Y, Imura T, Numajiri T, Nishino K, Fushiki S. Adipose-derived stem cells produce factors enhancing peripheral nerve regeneration: influence of age and anatomic site of origin. Stem Cells Dev 21(11): 1852-62, 2012.
  27. Nakamura K, Itoh K, Dai H, Han L, Wang X, Kato S, Sugimoto T, Fushiki S. Prenatal and lactational exposure to low-doses of bisphenol A alters adult mice behavior. Brain Dev. 34(1): 57-63, 2012.
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