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Department of Infectious Diseases

Subject Department of Infectious Diseases
Staff
Professor Takaaki Nakaya
 
 
Research Associate Professor      Minoru Yamada
Associate Professor Tomo Daidoji
Associate Professor Yohei Watanabe
Research Contents
Molecular mechanism of avian influenza virus pathogenesis: 
Research topics are focused on zoonotic viral infections, especially avian influenza viruses (AIVs). H5N1 and H7N9 AIVs raise serious worldwide concern about the risk of an influenza pandemic. We are using in vitro and animal experiments to study the role the viral glycoproteins and polymerase play in viral growth and cell toxicity. 
 
Metagenomic analysis of pathogens in humans: 
We are establishing a protocol to rapidly obtain the whole genome information of viral pathogens. This is expected to significantly accelerate the speed with which pathogens can be identified. Using this protocol, we have successfully demonstrated the presence of pathogenic microbes in clinical human samples without resorting to conventional selective procedures for specific pathogens. We also focus on environmental microbes for the metagenomics research.
Achievements
  1. Arai Y, Kawashita N, Daidoji T, Ibrahim MS, El-Gendy E, Takagi T, Takahashi K, Suzuki Y, Ikuta K, Nakaya T, Shioda T, Watanabe Y. Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses.PLoS Pathog. (in press)
  2. Nakamura S, Horie M, Daidoji T, Honda T, Yasugi M, Kuno A, Komori T, Okuzaki D, Narimatsu H, Nakaya T, Tomonaga K. Influenza A Virus-Induced Expression of a GalNAc Transferase, GALNT3, via MicroRNAs Is Required for Enhanced Viral Replication.J Virol. (2015) Dec 4;90(4):1788-801. doi: 10.1128/JVI.02246-15.
  3. Watanabe Y, Arai Y, Daidoji T, Kawashita N, Ibrahim MS, El-Gendy E, Hiramatsu H, Kubota-Kokestu R, Takagi T, Murata T, Takahashi K, Okuno Y, Nakaya T, Suzuki Y, Ikuta K. Characterization of H5N1 Influenza Virus Variants with Hemagglutinin Mutations Isolated from Patients.mBio. (2015) Apr 7:. 6 (2). e00081-15.doi:10.1128/mBio.00081-15.
  4. Okamoto M, Miyazawa T, Morikawa S, Ono F, Nakamura S, Sato E, Yoshida T, Yoshikawa R, Sakai K, Mizutani T, Nagata N, Takano J, Okabayashi S, Hamano M, Fujimoto K, Nakaya T, Iida T, Horii T, Miyabe-Nishiwaki T, Watanabe A, Kaneko A, Saito A, Matsui A, Hayakawa T, Suzuki J, Akari H, Matsuzawa T, Hirai H. Emergence of infectious malignant thrombocytopenia in Japanese macaques (Macaca fuscata) by SRV-4 after transmission to a novel host.Sci Rep. (2015) Mar 6;5:8850. doi: 10.1038/srep08850.
  5. Daidoji T, Watanabe Y, Ibrahim MS, Yasugi M, Maruyama H, Masuda T, Arai F, Ohba T, Honda A, Ikuta K, Nakaya T. Avian Influenza VirusInfection of Immortalized Human Respiratory Epithelial Cells Depends upon a Delicate Balance between Hemagglutinin Acid Stability and Endosomal pH.J Biol Chem. (2015) Apr 24;290(17):10627-42 pii: jbc.M114.611327.
  6. Motooka D, Nakamura S, Hagiwara K, Nakaya T. Viral detection by high-throughput sequencing. Methods Mol Biol. (2015) 1236:125-34.
  7. Yasugi M, Nakamura S, Daidoji T, Kawashita N, Ramadhany R, Yang CS, Yasunaga T, Iida T, Horii T, Ikuta K, Nakaya T. Frequency of D222G and Q223R hemagglutinin mutants of pandemic (H1N1) 2009 influenza virus in Japan between 2009 and 2010.PLoS ONE (2012)e30946.
  8. Arizono N, Miura T, Yamada M, Tegoshi T, Onishi K. Human infection with Pseudoterranova azarasi roundworm. Emerg Infect Dis. (2011) 17:555-6.

 

Contact TEL:+81-75-251-5325/5326
FAX:+81-75-251-5328
e-mail:tnakaya@koto.kpu-m.ac.jp
HP

602-8566 Kyoto-shi, Kamigyo-ku Kajii-cho,
Kawaramachi-Hirokoji, JAPAN

Contact
TEL:075-251-5111
FAX:075-251-7093