免疫内科学/内科学教室(内分泌・免疫内科学部門)

免疫内科学HP http://www.f.kpu-m.ac.jp/k/itinai/index.html

大学院科目名 免疫内科学
医学部教室名 内科学教室(内分泌・免疫内科学部門)
スタッフ
病院教授  川人 豊
 
 
講師    河野 正孝
助教    和田 誠
病院助教  藤岡 数記
研究内容
  1. 炎症・免疫疾患の病因と分子病態
  2. 線維化のメカニズム
  3. 炎症と動脈硬化
  4. 免疫疾患における骨髄由来細胞の役割
  5. 関節リウマチの病因における滑膜細胞の増殖機構
  6. 癌・免疫疾患にかかわる糖鎖異常
研究業績
代表的な研究論文
  • Nagahara H, YamamotoA,SenoT,Obayashi H,Kida T,Nakabayashi A, Kukida Y,Fujioka K,Fujii W,Murakami K,Kohno M,Kawahito Y.Allograft inflammatory factor-1 in the pothogenesis of bleomyein-inclued acute lung injury.Biosci Trends.10(1):47-53,2016.
  • Fujii W, Kawahito Y, Nagahara H, Kukita Y, Seno T, Yamamoto A, Kohno M, Oda R, Taniguchi D, Fujiwara H, Ejima A, Kishida T, Mazda O, Ashihara E. Monocarboxylate transporter 4, associated with the acidification of synovial fluid, is a novel therapeutic target for inflammatory arthritis. Arthritis Rheumatol.67(11):2888-96,2015.
  • Fujioka K, Kishida T, Ejima A, Yamamoto K, Fujii W, Murakami K, Seno T, Yamamoto A, Kohno M, Oda R, Yamamoto T, Fujiwara H, Kawahito Y, Mazda O. Inhibition of osteoclastogenesis by osteoblast-like cells genetically engineered to produce interleukin-10. Biochem Biophys Res Commun. 456(3):785-91, 2015.
  • MurakamiK, Kohno M, KadoyaM, NagaharaH, FujiiW, Seno T, YamamotoA, Oda R, Fujiwara H, KuboT, Morita S, Nakada H, Hla T, Kawahito Y. Knock out of S1P3 receptor signaling attenuates inflammation and fibrosis in bleomycin-induced lung injury mice model. Plos one. 2014. 9(9):e106792, 2014.
  • Kadoya M, Yamamoto A, Hamaguchi M, Obayashi H, Mizushima K, Ohta M, Seno T, Oda R, Fujiwara H, Kohno M, Kawahito Y. Allograft inflammatory factor-1 stimulates chemokine production and induces chemotaxis in human peripheral blood mononuclear cells. Biochem Biophys ResRes Commun.448(3):287-91, 2014
  • Fujii W, Ashihara E, Hirai H, Nagahara H, Kajitani N, Fujioka K, Murakami K, Seno T, Yamamoto A, Ishino H, Kohno M, Maekawa T, Kawahito Y. Myeloid-derived suppressor cells play crucial roles in the regulation of mouse collagen- induced arthritis. J Immunol. 191(3):1073-81, 2013.
  • Seno T, Hamaguchi M, Ashihara E, Kohno M, Ishino H, Yamamoto A, Kadoya M, Makamura K, Murakami K, Matoba S, Maekawa T, Kawahito Y. 15-Deoxy-Δ12,14 Prostaglandin J2 Reduces the Formation of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice. PLos one. 6(10):e25541, 2011.
  • Yamamoto A, Ashihara E, Nakagawa Y, Obayashi H, Ohta M, Hara H, Adachi T, Seno T, Kadoya M, Hamaguchi M, Ishino H, Kohno M, Maekawa T, Kawahito Y. Allograft inflammatory factor-1 is overexpressed and induces fibroblast chemotaxis in the skin of sclerodermatous GVHD in a murine model. Immunol Lett.135(1-2):144-50, 2011.
  • Ishino H, Kawahito Y, Hamaguchi M, Takeuchi N, Tokunaga D, Hojo T, Wada M, Yamamoto A, Kadoya M, Tsubouchi Y, Kohno M, Nakada H.Expression of Tn and sialyl Tn antigens in synovial tissues in rheumatoid arthritis. Clin Exp Rheumatol. 28:246-9, 2010.
  • Kawahito Y, Ichinose S, Sano H, Tsubouchi Y, Kohno M, Yoshikawa T, Tokunaga D, Hojo T, Harasawa R, Nakano T, Matsuda K. Mycoplasma fermentans glycolipid-antigen as a pathogen of rheumatoid arthritis. Biochem Biophys Res Commun. 369(2): 561-566, 2008.
  • Wada M, Kawahito Y, Kimura S, Kohno M, Ishino H, Kimura M, Omoto A, Yamamoto A, Hamaguchi M, Tsubouchi Y, Tokunaga D, Hojo T, Ashihara E, Maekawa T, Yoshikawa T. siRNA targeting PLK-1 induces apoptosis of synoviocytes in rheumatoid arthritis. Biochem Biophys Res Commun. 357(2): 353-359, 2007.
  • Kimura M, Kawahito Y, Obayashi H, Ohta M, Hara H, Adachi T, Tokunaga D, Hojo T, Hamaguchi M, Omoto A, Ishino H, Wada M, Kohno M, Tsubouchi Y, Yoshikawa T. A critical role for allograft inflammatory factor-1 in the pathogenesis of rheumatoid arthritis.J Immunol. 178(5): 3316-3322, 2007.
  • Omoto A, Kawahito Y, Prudovsky I, Tsubouchi Y, Kimura M, Ishino H, Wada M, Yoshida M, Kohno M, Yoshimura R, Yoshikawa T, Sano H. Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation- associated cachexia in rats. Arthritis Research & Therapy. 7(6): R1174-R1182, 2005.
  • Inaba T, Sano H, Kawahito Y, Hla T, Akita K, Toda M, Yamashina I, Inoue M, Nakada H. Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells. Proc Natl Acad Sci U S A. 100(5): 2736-2741, 2003.
  • Kohno M, Kawahito Y, Tsubouchi Y, Hashiramoto A, Yamada R, Inoue K, Kusaka Y, Kubo T, Elenkov IJ, Chrousos G.P, Kondo M, Sano H. Urocortin expression in synovium of patients with rheumatoid arthritis and osteoarthritis: relation to inflammatory activity. J Clin Endcrinol Metab. 86(9): 4344-4352, 2001.
  • Tsubouchi Y, Kawahito Y, Kohno M. Inoue K, Hla T, Sano H. Feedback control of the arachdonate cascade in rheumatoid synoviocytes by 15-deoxy-△12, 14-proaglandin J2. Biochem Biophys Res Commun. 283(4): 750-755, 2001.
  • Kawahito Y, Kondo M, Tsubouchi Y, Hashiramoto A, Bishop-Bailey D, Inoue K, Kohno M, Yamada R, Hla T, Sano H. 15-deoxy-Δ12,14-PGJ2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. J Clin Invest. 106(2): 189-197, 2000.
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