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医系化学/化学教室

化学教室HP https://kpu-m.medchem/index.html

大学院科目名 医系化学
医学部教室名 化学教室
スタッフ
  教授  大庭 誠
准教授 武元 宏泰
 
研究内容
 有機化学・合成化学基盤にモノをつくり、生命科学・基礎医学を取り入れて細胞や動物を用いた機能評価を行い、病気の予防・治療が可能な医薬品や研究ツールとして使える技術の開発を目指して、以下の研究に取り組んでいます。
研究業績
  1. Oba, M.*; Shibuya, M.; Yamaberi, Y.; Yokoo, H.; Uchida, S.; Ueda, A.; Tanaka, M.* An amphipathic structure of a dipropylglycine-containing helical peptide with sufficient length enables safe and effective intracellular siRNA delivery. Chem. Pharm. Bull. 2023, 71(3), 250-256.
    2. Yokoo, H.; Misawa, T.; Kato, T.; Tanaka, M.; Demizu, Y.*; Oba, M.* Development of delivery carriers for plasmid DNA by conjugation of a helical template to oligoarginine. Bioorg. Med. Chem. 2022, 72, 116997.
    3. Takemoto, H.*; Awaad, A.; Iizuka, M; Ogi, K.; Mochida, Y.; Ranneh, A. H.; Toyoda, M.; Matsui, M.; Nomoto, T.; Honda, Y.; Hayashi, K.; Tomoda, K.; Ohtake, T.; Miura, Y.; Nishiyama, N.* Changeable net charge on nanoparticles facilitates intratumor accumulation and penetration. J. Control. Release 2022, 346, 392-404.
    4. Uchida, S*; Yamaberi, Y.; Tanaka, M.; Oba, M.* A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of delivered mRNA. Nanoscale, 2021, 13(45), 18941-18946.
    5. Yamaberi, Y.; Eto, R.; Umeno, T.; Kato, T.; Doi, M.; Yokoo, H.; Oba, M.*; Tanaka, M.* Synthesis of (S)-(–)-cucurbitine and conformation of its homopeptides. Org. Lett. 2021, 23, 4358-4362.
    6. Komoto, K.; Nomoto, T.*; Muttaqien, S. E.; Takemoto, H.; Matsui, M.; Miura, Y.; Nishiyama, N.* Iron chelation cancer therapy using hydrophilic block copolymers conjugated with deferoxamine. Cancer Sci. 2021, 112, 410-421.
    7. Furukawa, K.; Tanaka, M.; Oba. M.* siRNA delivery using amphipathic cell-penetrating peptides into human hepatoma cells. Bioorg. Med. Chem. 2020, 28(8), 115402.
    8. Takemoto, H.*; Inaba, T.; Nomoto, T.; Matsui, M.; Liu, X.; Toyoda, M.; Honda, Y.; Taniwaki, K.; Yamada, N.; Kim, J.; Tomoda, K.; Nishiyama, N.* Polymeric modification of gemcitabine via cyclic acetal linkage for enhanced anticancer potency with negligible side effects. Biomaterials 2020, 235, 119804.
    9. Oba, M.*; Ito, Y.; Umeno, T.; Kato, T.; Tanaka, M. Plasmid DNA delivery using cell-penetrating peptide foldamers composed of Arg-Arg-Aib repeating sequences. ACS Biomater. Sci. Eng. 2019, 5, 5660-5668.
    10. Oba, M.*; Nagano, Y.; Kato, T.; Tanaka, M. Secondary structures and cell-penetrating abilities of arginine-rich peptide foldamers. Sci. Rep. 2019, 9, 1349.
    11. Takemoto, H.*; Wang, C. L.; Nomoto, T.; Matsui, M.; Tomoda, K.; Nishiyama, N.* Pyruvate responsiveness based on α-oxohydrazone formation for intracellular siRNA release from polyion complex (PIC)-based carriers. Biomacromolecules 2019, 20, 2305-2314.
    12. Takemoto, H.*; Ranneh, A.-H.; Sakuma, S.; Awaad, A.; Nomoto, T.; Mochida, Y.; Matsui, M.; Tomoda, K.; Naito, M.; Nishiyama, N.* An ethylenediamine‐based switch to render the polyzwitterion cationic at tumorous pH for effective tumor accumulation of coated nanomaterials. Angew. Chem. Int. Ed. 2018, 57, 5057-5061.
問い合わせ先
TEL: 075-703-4937
FAX: 075-703-4937
e-mail: moba@koto.kpu-m.ac.jp
教室独自のHP https://kpu-m.medchem.jp/index.html

〒602-8566. 京都市上京区河原町通広小路上る梶井町465

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